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Biology and Biochemistry

D-Index
73
Citations
20020
World Ranking
5910
National Ranking
2794

Overview

Hal S. Alper is affiliated with The University of Texas at Austin in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with 127 publications categorized in this broad field. More specifically, their work is concentrated in subfields such as molecular biology, biomedical engineering, biomaterials, pharmacology, and pollution.

The scientist's research topics include microbial metabolic engineering and bioproduction, biofuel production and bioconversion, viral infectious diseases and gene expression in insects, CRISPR and genetic engineering, enzyme catalysis and immobilization, biodegradable polymer synthesis and properties, and microplastics and plastic pollution.

Hal S. Alper has contributed to several recent scientific papers, including:

  • Machine learning-aided engineering of hydrolases for PET depolymerization, 2022, Nature
  • Applications, challenges, and needs for employing synthetic biology beyond the lab, 2021, Nature Communications
  • Compartmentalized microbes and co-cultures in hydrogels for on-demand bioproduction and preservation, 2020, Nature Communications
  • Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in Escherichia coli, 2021, Metabolic Engineering
  • De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture, 2020, Microbial Cell Factories

The frequent coauthors collaborating with Hal S. Alper include:

  • Sierra M. Brooks
  • Shuo-Fu Yuan
  • Andrew D. Ellington
  • Simon d'Oelsnitz
  • Sarah M. Coleman

The scientist regularly publishes in specific academic venues known for their relevance in the field. These frequent publication venues are:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Metabolic Engineering
  • ACS Synthetic Biology
  • Biotechnology Advances

Best Publications

  • Tuning genetic control through promoter engineering

    Hal S Alper;Curt Fischer;Elke Nevoigt;Elke Nevoigt;Gregory Stephanopoulos

  • Engineering yeast transcription machinery for improved ethanol tolerance and production.

    Hal Alper;Joel Moxley;Elke Nevoigt;Elke Nevoigt;Gerald R. Fink

  • Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production.

    John Blazeck;Andrew Hill;Leqian Liu;Rebecca Knight

  • Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

    Hal S Alper;Yong Su Jin;J. F. Moxley;G. Stephanopoulos

  • Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets.

    Hal S Alper;Kohei Miyaoku;Gregory Stephanopoulos

  • Global transcription machinery engineering: a new approach for improving cellular phenotype.

    Hal S. Alper;Gregory Stephanopoulos

  • Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?

    Hal S Alper;Gregory Stephanopoulos

  • Promoter engineering: recent advances in controlling transcription at the most fundamental level.

    John Blazeck;Hal S. Alper

  • Metabolic engineering of muconic acid production in Saccharomyces cerevisiae.

    Kathleen A. Curran;John M. Leavitt;Ashty S. Karim;Hal S. Alper

  • Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters

    John Blazeck;Rishi Garg;Ben Reed;Hal S. Alper

  • Tuning Gene Expression in Yarrowia lipolytica by a Hybrid Promoter Approach

    John Blazeck;Leqian Liu;Heidi Redden;Hal Alper

  • Engineering of Promoter Replacement Cassettes for Fine-Tuning of Gene Expression in Saccharomyces cerevisiae

    Elke Nevoigt;Elke Nevoigt;Jessica Kohnke;Curt R. Fischer;Hal S Alper

  • Expanding the metabolic engineering toolbox: more options to engineer cells.

    Keith E. Tyo;Hal S. Alper;Gregory N. Stephanopoulos

  • The development and characterization of synthetic minimal yeast promoters

    Heidi Redden;Hal S. Alper

  • Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances

    James M. Wagner;Hal S. Alper

  • Exploiting biological complexity for strain improvement through systems biology

    Gregory Stephanopoulos;Hal S Alper;Joel Moxley

  • Characterization of plasmid burden and copy number in Saccharomyces cerevisiae for optimization of metabolic engineering applications

    Ashty S. Karim;Kathleen A. Curran;Hal S. Alper

  • Use of expression-enhancing terminators in Saccharomyces cerevisiae to increase mRNA half-life and improve gene expression control for metabolic engineering applications.

    Kathleen A. Curran;Ashty S. Karim;Akash Gupta;Hal S. Alper

  • Short Synthetic Terminators for Improved Heterologous Gene Expression in Yeast

    Kathleen A. Curran;Nicholas J. Morse;Kelly A. Markham;Allison M. Wagman

  • Rewiring yeast sugar transporter preference through modifying a conserved protein motif

    Eric M. Young;Alice Tong;Hang Bui;Caitlin Spofford

Frequent Co-Authors

Yong Su Jin
Yong Su Jin University of Illinois at Urbana-Champaign
Fengwu Bai
Fengwu Bai Shanghai Jiao Tong University
Alshakim Nelson
Alshakim Nelson University of Washington
Jan Fang Cheng
Jan Fang Cheng Lawrence Berkeley National Laboratory
Maciek R. Antoniewicz
Maciek R. Antoniewicz University of Delaware
Christoph Wittmann
Christoph Wittmann Saarland University
Stefano Lonardi
Stefano Lonardi University of California, Riverside
Gregory F. Payne
Gregory F. Payne University of Maryland, College Park

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