World's Best Scientists 2026 revealed!
Ann Marie Pendergast

Ann Marie Pendergast

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
14975
World Ranking
11256
National Ranking
4874

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ann Marie Pendergast is affiliated with Duke University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. Within these fields, their work frequently addresses molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and cell biology.

The scientist's main research topics include:

  • Protein Degradation and Inhibitors
  • Hippo Pathway Signaling and YAP/TAZ
  • Peptidase Inhibition and Analysis
  • Endoplasmic Reticulum Stress and Disease
  • Multiple Myeloma Research and Treatments
  • Brain Metastases and Treatment
  • Glioma Diagnosis and Treatment

Ann Marie Pendergast has published work in several scientific venues. The most frequent publication outlets include:

  • Neuro-Oncology Advances
  • Proceedings of the National Academy of Sciences
  • Cell Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE

Selected recent papers include:

  • Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells, 2020, PLoS ONE
  • The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis, 2020, Proceedings of the National Academy of Sciences
  • Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade, 2021, Cell Communication and Signaling
  • Salting the Soil: Targeting the Microenvironment of Brain Metastases, 2021, Molecular Cancer Therapeutics
  • Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration, 2022, iScience

Frequent collaborators with whom Ann Marie Pendergast has co-authored multiple publications include Jacob P. Hoj, Benjamin Mayro, Kris C. Wood, Clay Rouse, and Jing Gu.

In recognition of their contributions to science, Ann Marie Pendergast was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

    Tracy G. Lugo;Ann-Marie Pendergast;Alexander J. Muller;Owen N. Witte

  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

    Ann Marie Pendergast;Lawrence A. Quilliam;Larry D. Cripe;Craig H. Bassing

  • Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

    Warren S. Pear;Juli P. Miller;Lanwei Xu;John C. Pui

  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

    Rina Plattner;Lisa Kadlec;Kris A. DeMali;Andrius Kazlauskas

  • A requirement for NF-κB activation in Bcr–Abl-mediated transformation

    Julie Y. Reuther;Gary W. Reuther;Gary W. Reuther;David Cortez;David Cortez;Ann Marie Pendergast

  • BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

    A J Muller;J C Young;A M Pendergast;M Pondel

  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

    Ann Marie Pendergast;Alexander J. Muller;Marie H. Havlik;Yoshiro Maru

  • Role of ABL family kinases in cancer: from leukaemia to solid tumours

    Emileigh K. Greuber;Pameeka Smith-Pearson;Jun Wang;Ann Marie Pendergast

  • The Abl family kinases: mechanisms of regulation and signaling.

    Ann Marie Pendergast

  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

    Z Dai;A M Pendergast

  • Expression of a Distinctive BCR-ABL Oncogene in Ph1-positive Acute Lymphocytic Leukemia (ALL)

    Steven S. Clark;Jami McLaughlin;Michael Timmons;Ann Marie Pendergast

  • Association of the Protein Kinases c-Bcr and Bcr-Abl with Proteins of the 14-3-3 Family

    GW Reuther;H Fu;H Fu;LD Cripe;RJ Collier

  • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

    David Cortez;Gary Reuther;Ann Marie Pendergast

  • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

    Cortez D;Stoica G;Pierce Jh;Pendergast Am

  • Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

    Ann Marie Pendergast;Alexander J. Muller;Marie H. Havlik;Robin Clark

  • Bcr-Abl variants: biological and clinical aspects.

    Anjali S. Advani;Ann Marie Pendergast

  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.

    Alexander J Finn;Guoping Feng;Ann Marie Pendergast

  • Abl tyrosine kinases are required for infection by Shigella flexneri

    Elizabeth A. Burton;Rina Plattner;Ann Marie Pendergast

  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.

    Theresia Stradal;Kevin D. Courtney;Klemens Rottner;Penelope Hahne

  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

    Rina Plattner;Brenda J. Irvin;Brenda J. Irvin;Shuling Guo;Shuling Guo;Kevin Blackburn

Frequent Co-Authors

Owen N. Witte
Owen N. Witte University of California, Los Angeles
Alexander J. Muller
Alexander J. Muller Lankenau Institute for Medical Research
David Cortez
David Cortez Vanderbilt University
Jolinda A. Traugh
Jolinda A. Traugh University of California, Riverside
Joseph Schlessinger
Joseph Schlessinger Yale University
Warren S. Pear
Warren S. Pear University of Pennsylvania
Anthony J. Koleske
Anthony J. Koleske Yale University
Andrius Kazlauskas
Andrius Kazlauskas University of Illinois at Chicago
Robert Sackstein
Robert Sackstein Florida International University
Robert T. Abraham
Robert T. Abraham Pfizer (United States)

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