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Molecular Biology
Spain
2026
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Genetics and Molecular Biology
Spain
2024

D-Index & Metrics

Molecular Biology

D-Index
105
Citations
39254
World Ranking
447
National Ranking
5

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Spain Leader Award
  • 2025 - Research.com Molecular Biology in Spain Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Spain Leader Award
  • 2023 - Research.com Molecular Biology in Spain Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Spain Leader Award
  • 1991 - Member of Academia Europaea
  • 1989 - Paul Ehrlich and Ludwig Darmstaedter Prize

Overview

Thomas Graf is affiliated with the Centre for Genomic Regulation in Spain. Their work spans several domains within biochemistry, genetics, and molecular biology, with significant contributions to the fields of molecular biology, artificial intelligence, computational theory and mathematics, immunology, and genetics.

Their research topics include:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Semigroups and Automata Theory
  • Natural Language Processing Techniques
  • Syntax, Semantics, Linguistic Variation
  • RNA Modifications and Cancer

Recent publications by Thomas Graf include:

  • "CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response," 2020, Nature Genetics
  • "Evidence for additive and synergistic action of mammalian enhancers during cell fate determination," 2021, eLife
  • "Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs," 2020, Nature Communications
  • "CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells," 2021, Nature Cell Biology
  • "Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning," 2021, Nature Communications

Thomas Graf has collaborated frequently with several coauthors, including:

  • Grégoire Stik
  • Luísa de Andrés-Aguayo
  • Tian V. Tian
  • Antonios Klonizakis
  • Maria Vila-Casadesús

The main venues in which they have published multiple times include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nature Communications
  • Nature Cell Biology
  • The EMBO Journal

Thomas Graf's publication record shows a focus on molecular mechanisms underlying gene regulation, chromatin dynamics, and transcriptional control, often integrating computational and theoretical approaches. Their work also extends to studies on immune cell behavior, enhancer dynamics during cell fate determination, and comparative developmental biology.

They have received recognition in the scientific community, including membership in the Academia Europaea since 1991 and the Paul Ehrlich and Ludwig Darmstaedter Prize awarded in 1989.

Best Publications

  • A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.

    Jeffrey Wyckoff;Weigang Wang;Elaine Y. Lin;Yarong Wang

  • Stepwise Reprogramming of B Cells into Macrophages

    Huafeng Xie;Min Ye;Ru Feng;Thomas Graf

  • Forcing cells to change lineages

    Thomas Graf;Tariq Enver

  • Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation.

    Hartmut Beug;Alexandra von Kirchbach;Gabriele Döderlein;Jean-Francois Conscience

  • Dynamic Visualization of Thrombopoiesis Within Bone Marrow

    Tobias Junt;Harald Schulze;Zhao Chen;Steffen Massberg

  • Human Monocytes Engage an Alternative Inflammasome Pathway

    Moritz M. Gaidt;Thomas S. Ebert;Dhruv Chauhan;Tobias Schmidt

  • Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages

    Nicole Faust;Florencio Varas;Louise M. Kelly;Susanne Heck

  • Avian leukemia viruses: interaction with their target cells in vivo and in vitro.

    Thomas Graf;Hartmut Beug

  • The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

    Scott A. Ness;Åsa Marknell;Thomas Graf

  • Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

    Toshihiro Miyamoto;Hiromi Iwasaki;Boris Reizis;Min Ye

  • GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

    H Kulessa;J Frampton;T Graf

  • PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

    Claus Nerlov;Thomas Graf

  • Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

    Ai Ing Lim;Ai Ing Lim;Ai Ing Lim;Yan Li;Yan Li;Silvia Lopez-Lastra;Silvia Lopez-Lastra;Silvia Lopez-Lastra;Ralph Stadhouders

  • Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

    M Roussel;S Saule;C Lagrou;C Rommens

  • Differentiation plasticity of hematopoietic cells.

    Thomas Graf

  • Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling

    Cara C. Bertozzi;Alec A. Schmaier;Patricia Mericko;Paul R. Hess

  • PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells

    Ru Feng;Sabrina C. Desbordes;Huafeng Xie;Ester Sanchez Tillo

  • GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription.

    Claus Nerlov;Erich Querfurth;Erich Querfurth;Holger Kulessa;Holger Kulessa;Thomas Graf;Thomas Graf

  • Transcription factors and 3D genome conformation in cell-fate decisions

    Ralph Stadhouders;Guillaume J. Filion;Thomas Graf

  • Reprogramming of Committed T Cell Progenitors to Macrophages and Dendritic Cells by C/EBPα and PU.1 Transcription Factors

    Catherine V. Laiosa;Matthias Stadtfeld;Huafeng Xie;Luisa de Andres-Aguayo

Frequent Co-Authors

Hartmut Beug
Hartmut Beug Research Institute of Molecular Pathology
Kelly M. McNagny
Kelly M. McNagny University of British Columbia
Achim Leutz
Achim Leutz Max Delbrück Center for Molecular Medicine
Dominique Stehelin
Dominique Stehelin Institut Pasteur
Jon Frampton
Jon Frampton University of Birmingham
Marc A. Marti-Renom
Marc A. Marti-Renom Pompeu Fabra University
Koichi Akashi
Koichi Akashi Kyushu University
Miguel Beato
Miguel Beato Centre for Genomic Regulation
Denis Thieffry
Denis Thieffry École Normale Supérieure

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