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Biology and Biochemistry

D-Index
46
Citations
8119
World Ranking
18931
National Ranking
1477

Overview

Peter N. Cockerill is affiliated with the University of Birmingham in the United Kingdom. Their research spans several areas within biochemistry, genetics, and molecular biology with a specific focus on hematology and immunology. The work predominantly addresses mechanisms relevant to leukemia and immune cell differentiation.

The scientist's research interests include acute myeloid leukemia, protein degradation and inhibitors, epigenetics and DNA methylation, genomics and chromatin dynamics, acute lymphoblastic leukemia, histone deacetylase inhibitors, and T-cell and B-cell immunology.

Frequent co-authors in their publications include Constanze Bonifer, Peter Keane, Salam A. Assi, Sophie G. Kellaway, and Paulynn Suyin Chin.

Peter N. Cockerill has published several papers in notable journals. Examples of recent papers include:

  • Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth, 2024, Nature Communications
  • Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia, 2022, Blood
  • Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1, 2021, Cell Reports
  • IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors, 2020, The EMBO Journal
  • Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes, 2020, Cell Reports

Peter N. Cockerill's work has been published in journals such as Experimental Hematology, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Reports, and Blood.

The main fields of study covered in their publications include biochemistry, genetics and molecular biology as well as medicine. These encompass subfields like molecular biology, hematology, immunology, public health, environmental and occupational health, and oncology.

Best Publications

  • Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

    Peter N. Cockerill;William T. Garrard

  • Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.

    Pu Xia;Jennifer R. Gamble;Kerry-Anne Rye;Lijun Wang

  • Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    Björn Lamprecht;Korden Walter;Stephan Kreher;Stephan Kreher;Raman Kumar

  • The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

    P N Cockerill;M H Yuen;W T Garrard

  • Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

    Jason Piper;Markus C. Elze;Pierre Cauchy;Peter N. Cockerill

  • The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

    P N Cockerill;M F Shannon;A G Bert;G R Ryan

  • Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

    A Ptasinska;S A Assi;D Mannari;S R James

  • A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples

    Geoffrey J. Laurent;Peter Cockerill;Robin J. McAnulty;Jeremy R.B. Hastings

  • The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.

    Pascal Lefevre;James Witham;Claire E. Lacroix;Peter N. Cockerill

  • Subtype-specific regulatory network rewiring in acute myeloid leukemia

    Salam A. Assi;Maria Rosaria Imperato;Daniel J. L. Coleman;Anna Pickin

  • Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.

    P N Cockerill;A G Bert;F Jenkins;G R Ryan

  • Structure and function of active chromatin and DNase I hypersensitive sites

    Peter N. Cockerill

  • Chromosomal loop anchorage sites appear to be evolutionarily conserved.

    Peter N. Cockerill;William T. Garrard

  • Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

    Anetta Ptasinska;Salam A. Assi;Salam A. Assi;Natalia Martinez-Soria;Maria Rosaria Imperato

  • Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

    Gillian W. Cockerill;Andrew G. Bert;Gregory R. Ryan;Jennifer R. Gamble

  • A T Cell–Specific Enhancer in the Interleukin-3 Locus Is Activated Cooperatively by Oct and NFAT Elements within a DNase I–Hypersensitive Site

    Kym N. Duncliffe;Andrew G. Bert;Mathew Alexander Vadas;Peter N. Cockerill

  • Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

    Sarah L Bevington;Pierre Cauchy;Jason Piper;Elisabeth Bertrand

  • Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

    Bauke de Boer;Janine Prick;Maurien G. Pruis;Peter Keane

  • Signals for Activation of the GM-CSF Promoter and Enhancer in T Cells

    M F Shannon;L S Coles;M A Vadas;P N Cockerill

  • The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

    Natalia Martinez-Soria;Lynsey McKenzie;Julia Draper;Anetta Ptasinska

Frequent Co-Authors

Constanze Bonifer
Constanze Bonifer University of Birmingham
Mathew A. Vadas
Mathew A. Vadas University of Sydney
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Graham H. Goodwin
Graham H. Goodwin Institute of Cancer Research
David R. Withers
David R. Withers University of Birmingham
Simon Bailey
Simon Bailey Royal Victoria Infirmary
Jennifer R. Gamble
Jennifer R. Gamble University of Sydney
Matthew Collin
Matthew Collin Newcastle University
Ruud Delwel
Ruud Delwel Erasmus MC
Reiner Siebert
Reiner Siebert University of Ulm

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