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Immunology

D-Index
48
Citations
8686
World Ranking
4434
National Ranking
383

Overview

David R. Withers is affiliated with the University of Birmingham in the United Kingdom. Their research spans across Immunology and Microbiology, with specific focus in subfields such as Immunology, Surgery, Oncology, Hepatology, and Molecular Biology.

The scientist's work primarily addresses topics including:

  • Immune Cell Function and Interaction
  • IL-33, ST2, and ILC Pathways
  • T-cell and B-cell Immunology
  • Eosinophilic Esophagitis
  • Immunotherapy and Immune Responses
  • Immune cells in cancer
  • Cancer Immunotherapy and Biomarkers

Their recent publications illustrate a focus on immune regulation within the gut, cancer progression, and interactions between microbiota and immune responses. Key papers include:

  • "ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut," 2022, Nature
  • "Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer," 2021, Cell
  • "A Pilot Integrative Analysis of Colonic Gene Expression, Gut Microbiota, and Immune Infiltration in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Association of Disease With Bile Acid Pathways," 2020, Journal of Crohn's and Colitis
  • "Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria," 2022, Cell Host & Microbe
  • "Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity," 2024, Nature Communications

David R. Withers has frequently collaborated with several researchers, including Isaac Dean (15 coauthored papers), Claire Willis (11), Rémi Fiancette (11), Fabrina Gaspal (10), and Zhi Li (10).

Their publications are often found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory) with 9 papers
  • Nature Communications with 4 papers
  • Science Immunology with 3 papers
  • Journal of Hepatology with 3 papers
  • Cancer Research with 3 papers

Best Publications

  • Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

    Ying Li;Silvia Innocentin;David R. Withers;Natalie A. Roberts

  • Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells

    Matthew R. Hepworth;Thomas C. Fung;Thomas C. Fung;Samuel H. Masur;Judith R. Kelsen

  • ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

    Unknown

  • Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

    Ye H. Oo;Chris J. Weston;Patricia F. Lalor;Stuart M. Curbishley

  • Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.

    David R Withers;Matthew R Hepworth;Xinxin Wang;Emma C Mackley

  • Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

    Timotheus Y.F. Halim;Timotheus Y.F. Halim;Batika M.J. Rana;Jennifer A. Walker;Bernhard Kerscher

  • CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.

    Ye Htun Oo;Vanessa Banz;Vanessa Banz;Dean Kavanagh;Evaggelia Liaskou

  • Inflammation-induced formation of fat-associated lymphoid clusters

    Cécile Bénézech;Nguyet-Thin Luu;Jennifer A Walker;Andrei A Kruglov;Andrei A Kruglov;Andrei A Kruglov

  • IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

    Francesca Barone;Francesca Barone;Saba Nayar;Saba Nayar;Joana Campos;Joana Campos;Thomas Cloake;Thomas Cloake

  • CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

    Emma C. Mackley;Stephanie Houston;Clare L. Marriott;Emily E. Halford

  • Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

    Hannah C. Jeffery;Bonnie van Wilgenburg;Ayako Kurioka;Krishan Parekh

  • IL-21 and BAFF/BLyS Synergize in Stimulating Plasma Cell Differentiation from a Unique Population of Human Splenic Memory B Cells

    Rachel Ettinger;Gary P. Sims;Rachel Robbins;David Withers

  • Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa.

    Ibrahim Eldaghayes;Lisa Rothwell;Andrew Williams;David Withers

  • Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium

    Natalie A. Roberts;Andrea J. White;William E. Jenkinson;Gleb Turchinovich;Gleb Turchinovich

  • Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer.

    Jeremy Goc;Mengze Lv;Nicholas J Bessman;Anne-Laure Flamar

  • Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.

    Michelle A. Linterman;Robert J. Rigby;Raphael Wong;Diego Silva

  • Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

    Jim G. Castellanos;Viola Woo;Monica Viladomiu;Gregory Putzel

  • Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

    Felipe Melo-Gonzalez;Felipe Melo-Gonzalez;Hana Kammoun;Elza Evren;Emma E Dutton

  • In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue

    Unknown

  • Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

    Unknown

  • T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

    James Phillip Hindley;Emma Jones;Kathryn Smart;Hayley Bridgeman

  • RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers.

    Sheeba Irshad;Fabian Flores-Borja;Katherine Lawler;James Monypenny

  • Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue

    David R Withers;Fabrina M Gaspal;Emma C Mackley;Clare L Marriott

Frequent Co-Authors

Peter J. L. Lane
Peter J. L. Lane University of Birmingham
Graham Anderson
Graham Anderson University of Birmingham
Toby Lawrence
Toby Lawrence King's College London
Christopher D. Buckley
Christopher D. Buckley University of Oxford
Gideon M. Hirschfield
Gideon M. Hirschfield University Health Network
Gregory F. Sonnenberg
Gregory F. Sonnenberg Cornell University
Marc Veldhoen
Marc Veldhoen University of Lisbon
Eric J. Jenkinson
Eric J. Jenkinson University of Birmingham
Paul Klenerman
Paul Klenerman University of Oxford
Tony Ng
Tony Ng King's College London

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