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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
14410
World Ranking
10749
National Ranking
4670

Overview

Allen Oliff is affiliated with GlaxoSmithKline in the United States, contributing to the field of biochemistry, genetics, and molecular biology. Their research integrates molecular biology techniques to explore mechanisms fundamental to development and disease.

The scientist's work primarily focuses on several key topics:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Polyamine metabolism and applications

Allen Oliff has contributed to the publication landscape with articles appearing in reputable journals, including at least one publication in ACS Medicinal Chemistry Letters. The available record highlights a paper titled "Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors", published in 2021.

This publication aligns with the scientist's interest in targeting pathways relevant to cancer biology, specifically through small-molecule inhibitors that may influence signaling cascades such as those involving tankyrases.

Frequent collaborators of Allen Oliff include researchers such as:

  • Donghui Qin
  • Xiaojuan Lin
  • Zhi Liu
  • Yan Chen
  • Zhiliu Zhang

The interdisciplinary approach spans molecular biology as a central subfield, reflecting the emphasis on understanding cellular processes at a molecular level. This focus supports investigations into both fundamental biology and translational applications related to cancer and metabolism.

Best Publications

  • Tumors secreting human TNF/cachectin induce cachexia in mice

    Allen Oliff;Deborah Defeo-Jones;Mark Boyer;Douglas Martinez

  • Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.

    NE Kohl;SD Mosser;SJ deSolms;EA Giuliani

  • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

    N E Kohl;C A Omer;M W Conner;N J Anthony

  • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic.

    Jackson B. Gibbs;Allen Oliff;Nancy E. Kohl

  • A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines

    Laura Sepp-Lorenzino;Zhenping Ma;Elaine Rands;Nancy E. Kohl

  • The potential of farnesyltransferase inhibitors as cancer chemotherapeutics.

    Jackson B. Gibbs;Allen Oliff

  • Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

    J. B. Gibbs;D. L. Pompliano;S. D. Mosser;E. Rands

  • Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

    Robert B. Lobell;Charles A. Omer;Marc T. Abrams;Hema G. Bhimnathwala

  • Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus.

    A I Oliff;G L Hager;E H Chang;E M Scolnick

  • Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

    M Ivey-Hoyle;R Conroy;H E Huber;P J Goodhart

  • Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

    Mark M. Moasser;Laura Sepp-Lorenzino;Nancy E. Kohl;Allen Oliff

  • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

    G C Prendergast;J P Davide;S J deSolms;E A Giuliani

  • A method of treating cancer

    David C. Heimbrook;Allen I. Oliff;Steven M. Stirdivant

  • Characterization of the retinoblastoma binding proteins RBP1 and RBP2.

    Fattaey Ar;Helin K;Dembski Ms;Dyson N

  • Pharmaceutical research in molecular oncology

    Jackson B. Gibbs;Allen Oliff

  • A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

    Rebecca E. Barrington;Mark A. Subler;Elaine Rands;Charles A. Omer

  • FRIEND MURINE LEUKEMIA VIRUS-INDUCED LEUKEMIA IS ASSOCIATED WITH THE FORMATION OF MINK CELL FOCUS-INDUCING VIRUSES AND IS BLOCKED IN MICE EXPRESSING ENDOGENOUS MINK CELL FOCUS-INDUCING XENOTROPIC VIRAL ENVELOPE GENES

    Sandra Ruscetti;Lenora Davis;John Feild;Allen Oliff

  • Genomes of murine leukemia viruses isolated from wild mice.

    S K Chattopadhyay;A I Oliff;D L Linemeyer;M R Lander

  • Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.

    P S Huang;D R Patrick;G Edwards;P J Goodhart

  • Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.

    Ramon Mangues;Teresa Corral;Nancy E. Kohl;William F Symmans

Frequent Co-Authors

Jackson B. Gibbs
Jackson B. Gibbs George Washington University
Nancy E. Kohl
Nancy E. Kohl Unnatural Products
George D. Hartman
George D. Hartman Janssen (Belgium)
John J. Donnelly
John J. Donnelly Novartis (United States)
Edward M. Scolnick
Edward M. Scolnick Broad Institute
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Frank McCormick
Frank McCormick University of California, San Francisco
Mark S. Marshall
Mark S. Marshall Indiana University
Douglas R. Lowy
Douglas R. Lowy National Institutes of Health
Said M. Sebti
Said M. Sebti Virginia Commonwealth University

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