World's Best Scientists 2026 revealed!

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Chemistry

D-Index
59
Citations
11645
World Ranking
10204
National Ranking
2837

Biology and Biochemistry

D-Index
60
Citations
12227
World Ranking
12008
National Ranking
5153

Overview

Hing L. Sham is affiliated with Global Blood Therapeutics in the United States, contributing to research in biomedical and clinical fields. They have published several papers primarily in the Journal of the Canadian Association of Gastroenterology, focusing on topics related to skin exposure, intestinal homeostasis, metabolism, and mucosal-microbe interactions.

Recent papers by Hing L. Sham include:

  • A2 UVB ON SKIN EXPOSURE MODULATES INTESTINAL HOMEOSTASIS IN MICE (2024) - Journal of the Canadian Association of Gastroenterology
  • A69 UVB SKIN EXPOSURE MODULATES INTESTINAL METABOLISM AND HOST DEFENSE (2025) - Journal of the Canadian Association of Gastroenterology
  • A2 USING BIOPSY-DERIVED ORGANOIDS AND GUT-ON-A-CHIP PLATFORM TO DEVELOP A PHYSIOLOGICALLY RELEVANT BACTERIAL INFECTION MODEL (2025) - Journal of the Canadian Association of Gastroenterology
  • A5 USING AIR-LIQUID INTERFACE ORGANOID MONOLAYERS TO DEFINE MUCOSAL-MICROBE DYSFUNCTION IN PATIENTS WITH ULCERATIVE COLITIS (2025) - Journal of the Canadian Association of Gastroenterology

Their research collaborations frequently include coauthors such as:

  • Bruce A. Vallance (4 collaborations)
  • M C Jimenez Sanchez (2 collaborations)
  • Jan Dutz (2 collaborations)
  • Brian Bressler (2 collaborations)
  • Hyungjun Yang (1 collaboration)

Hing L. Sham's work demonstrated interest in using innovative models such as biopsy-derived organoids and gut-on-a-chip platforms to investigate bacterial infections and mucosal-microbe dysfunction. Other studies focus on the biological effects of UVB skin exposure on intestinal health and host defense systems.

The primary venue for their published work is the Journal of the Canadian Association of Gastroenterology, where their recent contributions address gastrointestinal biology with an emphasis on novel methodological approaches and interactions between skin exposure and intestinal responses.

Best Publications

  • ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

    D J Kempf;K C Marsh;J F Denissen;E McDonald

  • Retroviral protease inhibiting compounds.

    Dale J. Kempf;Daniel W. Norbeck;Hing Leung Sham;Chen Zhao

  • ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

    Hing L. Sham;Dale J. Kempf;Akhteruzammen Molla;Kennan C. Marsh

  • Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

    Le Wang;Keith W. Woods;Qun Li;Kenneth J. Barr

  • Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

    Dale J. Kempf;Hing L. Sham;Kennan C. Marsh;Charles A. Flentge

  • Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System*S⃞

    Unknown

  • Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus☆

    Akhteruzzaman Molla;Sudthida Vasavanonda;Gondi Kumar;Hing L. Sham

  • In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor

    Alejandro Carrillo;Kent D. Stewart;Hing L. Sham;Daniel W. Norbeck

  • Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity†

    Bruce G Szczepankiewicz;Christi Kosogof;Lissa T J Nelson;Gang Liu

  • Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.

    Gang Zhao;Andrew J Souers;Martin Voorbach;H Doug Falls

  • Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

    Wang Gt;Chen Y;Wang S;Gentles R

  • Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

    Gang Liu;John K Lynch;Jennifer Freeman;Bo Liu

  • Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

    Zehan Chen;Zhan Xiao;Wen-zhen Gu;John Xue

  • Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

    Vincent Stoll;Kent D. Stewart;Clarence J. Maring;Steven Muchmore

  • Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.

    D W Norbeck;E Kern;S Hayashi;W Rosenbrook

  • Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.

    Qun Li;Keith W. Woods;Akiyo Claiborne;Stephen L. Gwaltney

  • Inhibition and catalytic mechanism of HIV-1 aspartic protease.

    Unknown

  • Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint

    Zehan Chen;Zhan Xiao;Jun Chen;Shi-Chung Ng

  • Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.

    Andrew J. Souers;Ju Gao;Michael Brune;Eugene Bush

  • Metabolism and disposition of the HIV-1 protease inhibitor lopinavir (ABT-378) given in combination with ritonavir in rats, dogs, and humans.

    Gondi N. Kumar;Venkata K. Jayanti;Marianne K. Johnson;John Uchic

  • X-ray Crystallographic Structure of ABT-378 (Lopinavir) Bound to HIV-1 Protease

    Vincent Stoll;Wenying Qin;Kent D. Stewart;Clarissa Jakob

  • Discovery and structure-activity relationships of piperidinone-and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors

    Zhonghua Pei;Xiaofeng Li;Thomas W von Geldern;Kenton Longenecker

Frequent Co-Authors

Jacob J. Plattner
Jacob J. Plattner Pfizer (United States)
Saul H. Rosenberg
Saul H. Rosenberg AbbVie (United States)
Kennan C. Marsh
Kennan C. Marsh AbbVie (United States)

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