World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
59
Citations
12477
World Ranking
10133
National Ranking
2817

Overview

Jacob J. Plattner is affiliated with Pfizer in the United States and focuses their research efforts primarily within the field of Medicine. Their work spans several subfields including Public Health, Environmental and Occupational Health, Epidemiology, Infectious Diseases, Parasitology, and Health, Toxicology and Mutagenesis.

The scientist's recent publications reflect involvement in research concerning parasitic diseases and their control. Notable papers include:

  • Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation, 2020, published in mBio
  • In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis, 2020, published in PLoS neglected tropical diseases

Their work covers main research topics such as:

  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Trypanosoma species research and implications
  • Parasitic Diseases Research and Treatment
  • Parasites and Host Interactions
  • Insects and Parasite Interactions

Frequent co-authors collaborating with Jacob J. Plattner include Eric E. Easom, Yvonne R. Freund, Kirthana M. V. Sindhe, Wesley Wu, and Jenny Legac.

The majority of their publications appear in the journals mBio and PLoS neglected tropical diseases, both of which align with their focus on infectious and parasitic diseases.

Best Publications

  • Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.

    J Erickson;D.J Neidhart;J VanDrie;D.J Kempf

  • An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.

    Fernando L. Rock;Weimin Mao;Anya Yaremchuk;Mikhail Tukalo

  • ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

    Hing L. Sham;Dale J. Kempf;Akhteruzammen Molla;Kennan C. Marsh

  • Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

    D J Kempf;K C Marsh;G Kumar;A D Rodrigues

  • New directions in antibacterial research.

    Daniel T. W. Chu;Jacob J. Plattner;Leonard Katz

  • Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

    Stephen J Baker;Yong-Kang Zhang;Tsutomu Akama;Agnes Lau

  • A synthesis of protected aminoalkyl epoxides from .alpha.-amino acids

    Jay R. Luly;Joseph F. Dellaria;Jacob J. Plattner;Jeffrey L. Soderquist

  • Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

    Dale J. Kempf;Hing L. Sham;Kennan C. Marsh;Charles A. Flentge

  • Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

    Tsutomu Akama;Stephen J. Baker;Yong-Kang Zhang;Vincent Hernandez

  • Boron-containing small molecules

    Stephen J. Baker;Tsutomu Akama;Carolyn Bellinger-Kawahara;Vincent S. Hernandez

  • Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

    Vincent Hernandez;Thibaut Crépin;Andrés Palencia;Stephen Cusack

  • Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

    Xianfeng Li;Vincent Hernandez;Fernando L. Rock;Wai Choi

  • Synthesis of some DE and CDE ring analogs of camptothecin.

    Jacob J. Plattner;Richard D. Gless;Henry Rapoport

  • Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

    Zhenkun Ma;Richard F. Clark;Antony Brazzale;Sanyi Wang

  • Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.

    Elena Seiradake;Weimin Mao;Vincent Hernandez;Stephen J. Baker

  • New inhibitors of human renin that contain novel Leu-Val replacements.

    Jay R. Luly;Nwe Yi;Jeff Soderquist;Herman Stein

  • New inhibitors of renin that contain novel phosphostatine Leu-Val replacements.

    Joseph F. Dellaria;Robert G. Maki;Herman H. Stein;Jerome Cohen

  • 6-o-substituted ketolides having antibacterial activity

    Daniel T. Chu;Richard F. Clark;Zhenkun Ma;Yat Sun Or

  • Boron-containing small molecules as anti-inflammatory agents

    Stephen J. Baker;Virginia Sanders;Tsutsomu Akama;Carolyn Bellinger-Kawahara

  • Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.

    Andrés Palencia;Xianfeng Li;Wei Bu;Wai Choi

  • Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.

    Yi Xia;Kathy Cao;Yasheen Zhou;M.R.K. Alley

Frequent Co-Authors

Hing L. Sham
Hing L. Sham Global Blood Therapeutics (United States)
Kennan C. Marsh
Kennan C. Marsh AbbVie (United States)
Philip J. Rosenthal
Philip J. Rosenthal University of California, San Francisco
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
Cyrus J. Bacchi
Cyrus J. Bacchi Pace University
Robert K. Flamm
Robert K. Flamm JMI Laboratories
David M. Livermore
David M. Livermore University of East Anglia
Reto Brun
Reto Brun University of Basel
Robert G. Maki
Robert G. Maki University of Pennsylvania
Marina Warner
Marina Warner Public Health England

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