World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
32763
World Ranking
1827
National Ranking
1006

Research.com Recognitions

  • 2005 - Polish Academy of Science

Overview

Alexander Wlodawer is affiliated with the National Institutes of Health in the United States. Their research spans multiple aspects of biochemistry, molecular biology, and medicine, with a significant focus on enzyme structure and function as well as protein structure and dynamics.

Their work has contributed to understanding various biochemical and molecular research topics, including acute lymphoblastic leukemia, RNA and protein synthesis mechanisms, malaria research and control, and SARS-CoV-2 and COVID-19 research.

Frequent publication venues for Alexander Wlodawer include:

  • FEBS Journal
  • Acta Crystallographica Section A Foundations and Advances
  • Biochemistry
  • IUCrJ
  • Protein Science

Regular co-authors collaborating with Alexander Wlodawer include:

  • Séamus J. Martin
  • Dublin Chair
  • Andrey Abramov
  • Colin Adrain
  • Cecília M. Arraiano

Notable recent publications of Alexander Wlodawer are:

  • "A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication", 2021, Nature Communications
  • "Structural and biochemical properties of L-asparaginase", 2021, FEBS Journal
  • "Mechanism of Catalysis by l-Asparaginase", 2020, Biochemistry
  • "Ligand-centered assessment of SARS-CoV-2 drug target models in the Protein Data Bank", 2020, FEBS Journal
  • "Structure and the Mode of Activity of Lon Proteases from Diverse Organisms", 2022, Journal of Molecular Biology

Alexander Wlodawer's main fields of study encompass Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields of their research include Molecular Biology, Materials Chemistry, Public Health, Environmental and Occupational Health, Infectious Diseases, and Immunology.

The research topics often addressed by this scientist focus on:

  • Enzyme Structure and Function
  • Protein Structure and Dynamics
  • Biochemical and Molecular Research
  • Acute Lymphoblastic Leukemia research
  • RNA and protein synthesis mechanisms
  • Malaria Research and Control
  • SARS-CoV-2 and COVID-19 Research

Alexander Wlodawer received an award from the Polish Academy of Science in 2005.

Best Publications

  • Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

    Alexander Wlodawer;Maria Miller;Mariusz Jaskólski;Bangalore K. Sathyanarayana

  • STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

    Alexander Wlodawer;John W. Erickson

  • Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.

    Alexander Wlodawer;Jiri Vondrasek

  • Catalytic triads and their relatives

    Guy Dodson;Alexander Wlodawer

  • Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution.

    Maria Miller;Jens Schneider;Bangalore K. Sathyanarayana;Mihaly V. Toth

  • New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

    N.Q McDonald;R Lapatto;J Murray-Rust;J Gunning

  • Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray refinement of crystal form II

    Alexander Wlodawer;Alexander Wlodawer;Jochen Walter;Robert Huber;Lennart Sjölin

  • Crystal structure of a retroviral protease proves relationship to aspartic protease family.

    Maria Miller;Mariusz Jaskólski;J. K. Mohana Rao;Jonathan Leis

  • Structure of phosphate-free ribonuclease A refined at 1.26 A.

    A Wlodawer;L.A Svensson;L Sjolin;G.L. Gilliland

  • Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures.

    Alexander Wlodawer;Wladek Minor;Zbigniew Dauter;Mariusz Jaskolski;Mariusz Jaskolski

  • Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.

    A.L. Swain;M. Jaskolski;D. Housset;J.K.M. Rao

  • X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

    Amy L. Swain;Maria M. Miller;Jeremy Green;Daniel H. Rich

  • 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.

    Ashraf Brik;Jerry Alexandratos;Ying-Chuan Lin;John H. Elder

  • The structural basis for spectral variations in green fluorescent protein.

    Gottfried J. Palm;Alexander Zdanov;George A. Gaitanaris;Roland Stauber

  • Structural basis for the substrate specificity of tobacco etch virus protease.

    Jason Phan;Alexander Zdanov;Artem G. Evdokimov;Joseph E. Tropea

  • Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.

    Alexander Zdanov;Céline Schalk-Hihi;Alla Gustchina;Monica Tsang

  • Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor

    Alexander Wlodawer;Alexander Wlodawer;Johann Deisenhofer;Robert Huber

  • Structure of form III crystals of bovine pancreatic trypsin inhibitor.

    Alexander Wlodawer;Joseph Nachman;Gary L. Gilliland;Warren Gallagher

  • Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.

    Mariusz Jaskolski;Alfredo G. Tomasselli;Tomi K. Sawyer;Douglas G. Staples

  • INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted

    Alexander Wlodawer;Jiri Vondrasek

Frequent Co-Authors

Mariusz Jaskolski
Mariusz Jaskolski Adam Mickiewicz University in Poznań
Ben M. Dunn
Ben M. Dunn University of Florida
Wladek Minor
Wladek Minor University of Virginia
Gary L. Gilliland
Gary L. Gilliland National Institute of Standards and Technology
Andreas Hofmann
Andreas Hofmann University of Melbourne
Barry R. O'Keefe
Barry R. O'Keefe National Institutes of Health
Stephen B. H. Kent
Stephen B. H. Kent University of Chicago
Jonathan Leis
Jonathan Leis Northwestern University
Anna Marie Skalka
Anna Marie Skalka Fox Chase Cancer Center
Richard A. Katz
Richard A. Katz Fox Chase Cancer Center

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