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Chemistry

D-Index
48
Citations
8779
World Ranking
15196
National Ranking
3859

Biology and Biochemistry

D-Index
53
Citations
9696
World Ranking
16206
National Ranking
6715

Overview

Barry R. O'Keefe is primarily affiliated with the National Institutes of Health in the United States. Their research contributions span multiple fields, with significant activity in biochemistry, genetics, and molecular biology, as well as medicine. More specifically, their work touches on molecular biology, biotechnology, pharmacology, organic chemistry, and materials chemistry.

Their main research topics focus on marine sponges and natural products, microbial natural products and biosynthesis, synthesis and biological activity, crystallization and solubility studies, X-ray diffraction in crystallography, cancer therapeutics and mechanisms, and chemical synthesis and analysis.

Barry R. O'Keefe has published extensively, with notable papers including:

  • Creating and screening natural product libraries (2020) published in Natural Product Reports
  • National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library (2020) published in ACS Chemical Biology
  • Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge (2020) published in The Journal of Infectious Diseases
  • Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model (2021) published in Marine Drugs
  • Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library (2023) published in ACS Infectious Diseases

Their frequent co-authors include Tanja Grkovic, Brice A. P. Wilson, Robert H. Cichewicz, Dongdong Wang, and Susan L. Mooberry.

Barry R. O'Keefe often publishes in various scientific venues. Some frequent publication venues are:

  • Journal of Natural Products (18 publications)
  • The Cambridge Structural Database (6 publications)
  • Marine Drugs (3 publications)
  • Cancer Research (3 publications)
  • Organic Letters (2 publications)

Best Publications

  • Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

    M R Boyd;K R Gustafson;J B McMahon;R H Shoemaker

  • Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.

    Toshiyuki Mori;Barry R. O'Keefe;Raymond C. Sowder;Scott Bringans

  • Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

    Barry R. O'Keefe;Barbara Giomarelli;Dale L. Barnard;Shilpa R. Shenoy

  • Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.

    Eddie W Adams;Daniel M Ratner;Heidi R Bokesch;James B McMahon

  • Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

    Barry R. O'Keefe;Fakhrieh Vojdani;Viviana Buffa;Robin J. Shattock

  • Probing Protein–Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides

    Daniel M. Ratner;Eddie W. Adams;Jing Su;Barry R. O'Keefe

  • A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium†

    Heidi R. Bokesch;Barry R. O'keefe;Tawnya C. Mckee;Lewis K. Pannell

  • Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides.

    Istvan Botos;Barry R. O’Keefe;Shilpa R. Shenoy;Laura K. Cartner

  • Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

    Barry R. O'Keefe;Donald F. Smee;Jim A. Turpin;Carrie J. Saucedo

  • Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus☆

    Laura G. Barrientos;Barry R. O’Keefe;Mike Bray;Anthony Sanchez

  • Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.

    Anders J. Bolmstedt;Barry R. O'Keefe;Shilpa R. Shenoy;James B. McMahon

  • Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding

    Natasza E. Ziółkowska;Barry R. O'Keefe;Toshiyuki Mori;Charles Zhu

  • The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.

    Laura G. Barrientos;John M. Louis;Istvan Botos;Toshiyuki Mori

  • Antiviral lectins: Selective inhibitors of viral entry.

    Carter A. Mitchell;Koreen Ramessar;Barry R. O'Keefe

  • Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti‐HIV microbicide

    P. Emau;B. Tian;B. R. O'Keefe;T. Mori

  • NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

    Christopher C. Thornburg;John R. Britt;Jason R. Evans;Rhone K. Akee

  • Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

    Donald F. Smee;Kevin W. Bailey;Min-Hui Wong;Barry R. O’Keefe

  • Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

    Joanna Sztuba-Solinska;Shilpa R. Shenoy;Peter Gareiss;Lauren R. H. Krumpe

  • Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

    Yutaka Takebe;Carrie J. Saucedo;Garry Lund;Rie Uenishi

  • Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins

    Shilpa R. Shenoy;Barry R. O'Keefe;Anders J. Bolmstedt;Laura K. Cartner

  • Creating and screening natural product libraries

    Brice A P Wilson;Christopher C Thornburg;Curtis J Henrich;Tanja Grkovic

  • Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

    Myriam Witvrouw;Valery Fikkert;Anke Hantson;Christophe Pannecouque

Frequent Co-Authors

James B. McMahon
James B. McMahon National Institutes of Health
John A. Beutler
John A. Beutler National Institutes of Health
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Kirk R. Gustafson
Kirk R. Gustafson National Institutes of Health
Michael R. Boyd
Michael R. Boyd University of South Alabama
Michael R. Boyd
Michael R. Boyd National Cancer Institute
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Alexander Wlodawer
Alexander Wlodawer National Institutes of Health
Christophe Marchand
Christophe Marchand National Institutes of Health
Yves Pommier
Yves Pommier National Institutes of Health

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