World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9696
World Ranking
16206
National Ranking
6715

Chemistry

D-Index
48
Citations
8779
World Ranking
15194
National Ranking
3858

Barry R. O'Keefe publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Barry R. O'Keefe sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 144 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Barry R. O'Keefe D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Barry R. O'Keefe sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 48 D-Index — 16th percentile

16% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Barry R. O'Keefe is primarily affiliated with the National Institutes of Health in the United States. Their research contributions span multiple fields, with significant activity in biochemistry, genetics, and molecular biology, as well as medicine. More specifically, their work touches on molecular biology, biotechnology, pharmacology, organic chemistry, and materials chemistry.

Their main research topics focus on marine sponges and natural products, microbial natural products and biosynthesis, synthesis and biological activity, crystallization and solubility studies, X-ray diffraction in crystallography, cancer therapeutics and mechanisms, and chemical synthesis and analysis.

Barry R. O'Keefe has published extensively, with notable papers including:

  • Creating and screening natural product libraries (2020) published in Natural Product Reports
  • National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library (2020) published in ACS Chemical Biology
  • Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge (2020) published in The Journal of Infectious Diseases
  • Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model (2021) published in Marine Drugs
  • Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library (2023) published in ACS Infectious Diseases

Their frequent co-authors include Tanja Grkovic, Brice A. P. Wilson, Robert H. Cichewicz, Dongdong Wang, and Susan L. Mooberry.

Barry R. O'Keefe often publishes in various scientific venues. Some frequent publication venues are:

  • Journal of Natural Products (18 publications)
  • The Cambridge Structural Database (6 publications)
  • Marine Drugs (3 publications)
  • Cancer Research (3 publications)
  • Organic Letters (2 publications)

Best Publications

  • Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

    M R Boyd;K R Gustafson;J B McMahon;R H Shoemaker

  • Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.

    Toshiyuki Mori;Barry R. O'Keefe;Raymond C. Sowder;Scott Bringans

  • Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

    Barry R. O'Keefe;Barbara Giomarelli;Dale L. Barnard;Shilpa R. Shenoy

  • Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.

    Eddie W Adams;Daniel M Ratner;Heidi R Bokesch;James B McMahon

  • Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

    Barry R. O'Keefe;Fakhrieh Vojdani;Viviana Buffa;Robin J. Shattock

  • Probing Protein–Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides

    Daniel M. Ratner;Eddie W. Adams;Jing Su;Barry R. O'Keefe

  • A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium†

    Heidi R. Bokesch;Barry R. O'keefe;Tawnya C. Mckee;Lewis K. Pannell

  • Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides.

    Istvan Botos;Barry R. O’Keefe;Shilpa R. Shenoy;Laura K. Cartner

  • Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

    Barry R. O'Keefe;Donald F. Smee;Jim A. Turpin;Carrie J. Saucedo

  • Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus☆

    Laura G. Barrientos;Barry R. O’Keefe;Mike Bray;Anthony Sanchez

  • Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.

    Anders J. Bolmstedt;Barry R. O'Keefe;Shilpa R. Shenoy;James B. McMahon

  • Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding

    Natasza E. Ziółkowska;Barry R. O'Keefe;Toshiyuki Mori;Charles Zhu

  • The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.

    Laura G. Barrientos;John M. Louis;Istvan Botos;Toshiyuki Mori

  • Antiviral lectins: Selective inhibitors of viral entry.

    Carter A. Mitchell;Koreen Ramessar;Barry R. O'Keefe

  • Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti‐HIV microbicide

    P. Emau;B. Tian;B. R. O'Keefe;T. Mori

  • NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

    Christopher C. Thornburg;John R. Britt;Jason R. Evans;Rhone K. Akee

  • Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

    Donald F. Smee;Kevin W. Bailey;Min-Hui Wong;Barry R. O’Keefe

  • Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

    Joanna Sztuba-Solinska;Shilpa R. Shenoy;Peter Gareiss;Lauren R. H. Krumpe

  • Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

    Yutaka Takebe;Carrie J. Saucedo;Garry Lund;Rie Uenishi

  • Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins

    Shilpa R. Shenoy;Barry R. O'Keefe;Anders J. Bolmstedt;Laura K. Cartner

  • Creating and screening natural product libraries

    Brice A P Wilson;Christopher C Thornburg;Curtis J Henrich;Tanja Grkovic

  • Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

    Myriam Witvrouw;Valery Fikkert;Anke Hantson;Christophe Pannecouque

Frequent Co-Authors

James B. McMahon
James B. McMahon National Institutes of Health
John A. Beutler
John A. Beutler National Institutes of Health
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Kirk R. Gustafson
Kirk R. Gustafson National Institutes of Health
Michael R. Boyd
Michael R. Boyd University of South Alabama
Michael R. Boyd
Michael R. Boyd National Cancer Institute
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Alexander Wlodawer
Alexander Wlodawer National Institutes of Health
Christophe Marchand
Christophe Marchand National Institutes of Health
Yves Pommier
Yves Pommier National Institutes of Health

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