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Barry R. O'Keefe

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 48 15194 13692 3858 3162 144 8779
Biology and Biochemistry 53 16199 14872 6712 5998 169 9696

Barry R. O'Keefe publications per year

The chart shows the history of publications by Barry R. O'Keefe between 1993 and 2026, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Barry R. O'Keefe published across 34 years, from 1993 to 2026, averaging 6.8 papers a year. Output peaked at 16 publications in 2021. 18 of the 232 publications appeared in the last two years.

No. of publications
5 10 15
Bar chart. Horizontal axis: year, 1993 to 2026. Vertical axis: number of publications, 0 to 16. Peak 16 publications in 2021. 1993: 1 publication 1994: 0 publications 1995: 0 publications 1996: 0 publications 1997: 4 publications 1998: 2 publications 1999: 1 publication 2000: 3 publications 2001: 3 publications 2002: 13 publications 2003: 9 publications 2004: 6 publications 2005: 5 publications 2006: 4 publications 2007: 8 publications 2008: 6 publications 2009: 4 publications 2010: 9 publications 2011: 4 publications 2012: 4 publications 2013: 4 publications 2014: 8 publications 2015: 11 publications 2016: 11 publications 2017: 6 publications 2018: 9 publications 2019: 9 publications 2020: 14 publications 2021: 16 publications 2022: 9 publications 2023: 16 publications 2024: 15 publications 2025: 16 publications 2026: 2 publications
1993 2026

232 publications in total across all disciplines

View publications per year as a table
Barry R. O'Keefe: publications per year, 1993 to 2026
Year Publications
1993 1
1994 0
1995 0
1996 0
1997 4
1998 2
1999 1
2000 3
2001 3
2002 13
2003 9
2004 6
2005 5
2006 4
2007 8
2008 6
2009 4
2010 9
2011 4
2012 4
2013 4
2014 8
2015 11
2016 11
2017 6
2018 9
2019 9
2020 14
2021 16
2022 9
2023 16
2024 15
2025 16
2026 2
Total 232
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Barry R. O'Keefe publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Barry R. O'Keefe sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 141–160 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 144 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623
121–140 918
141–160 1,218 144
161–180 1,350
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270
461–480 265
481–500 252
501–520 201
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Barry R. O'Keefe D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Barry R. O'Keefe sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 48–49 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 48 D-Index — 16th percentile

16% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289
42–43 612
44–45 808
46–47 776
48–49 835 48
50–51 861
52–53 872
54–55 933
56–57 1,051
58–59 930
60–61 882
62–63 834
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
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Overview

Barry R. O'Keefe is primarily affiliated with the National Institutes of Health in the United States. Their research contributions span multiple fields, with significant activity in biochemistry, genetics, and molecular biology, as well as medicine. More specifically, their work touches on molecular biology, biotechnology, pharmacology, organic chemistry, and materials chemistry.

Their main research topics focus on marine sponges and natural products, microbial natural products and biosynthesis, synthesis and biological activity, crystallization and solubility studies, X-ray diffraction in crystallography, cancer therapeutics and mechanisms, and chemical synthesis and analysis.

Barry R. O'Keefe has published extensively, with notable papers including:

  • Creating and screening natural product libraries (2020) published in Natural Product Reports
  • National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library (2020) published in ACS Chemical Biology
  • Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge (2020) published in The Journal of Infectious Diseases
  • Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model (2021) published in Marine Drugs
  • Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library (2023) published in ACS Infectious Diseases

Their frequent co-authors include Tanja Grkovic, Brice A. P. Wilson, Robert H. Cichewicz, Dongdong Wang, and Susan L. Mooberry.

Barry R. O'Keefe often publishes in various scientific venues. Some frequent publication venues are:

  • Journal of Natural Products (18 publications)
  • The Cambridge Structural Database (6 publications)
  • Marine Drugs (3 publications)
  • Cancer Research (3 publications)
  • Organic Letters (2 publications)

Best Publications

  • Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

    M R Boyd;K R Gustafson;J B McMahon;R H Shoemaker

  • Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.

    Toshiyuki Mori;Barry R. O'Keefe;Raymond C. Sowder;Scott Bringans

  • Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

    Barry R. O'Keefe;Barbara Giomarelli;Dale L. Barnard;Shilpa R. Shenoy

  • Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.

    Eddie W Adams;Daniel M Ratner;Heidi R Bokesch;James B McMahon

  • Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

    Barry R. O'Keefe;Fakhrieh Vojdani;Viviana Buffa;Robin J. Shattock

  • Probing Protein–Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides

    Daniel M. Ratner;Eddie W. Adams;Jing Su;Barry R. O'Keefe

  • A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium†

    Heidi R. Bokesch;Barry R. O'keefe;Tawnya C. Mckee;Lewis K. Pannell

  • Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides.

    Istvan Botos;Barry R. O’Keefe;Shilpa R. Shenoy;Laura K. Cartner

  • Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

    Barry R. O'Keefe;Donald F. Smee;Jim A. Turpin;Carrie J. Saucedo

  • Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus☆

    Laura G. Barrientos;Barry R. O’Keefe;Mike Bray;Anthony Sanchez

  • Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.

    Anders J. Bolmstedt;Barry R. O'Keefe;Shilpa R. Shenoy;James B. McMahon

  • Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding

    Natasza E. Ziółkowska;Barry R. O'Keefe;Toshiyuki Mori;Charles Zhu

  • The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.

    Laura G. Barrientos;John M. Louis;Istvan Botos;Toshiyuki Mori

  • Antiviral lectins: Selective inhibitors of viral entry.

    Carter A. Mitchell;Koreen Ramessar;Barry R. O'Keefe

  • Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti‐HIV microbicide

    P. Emau;B. Tian;B. R. O'Keefe;T. Mori

  • NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

    Christopher C. Thornburg;John R. Britt;Jason R. Evans;Rhone K. Akee

  • Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

    Donald F. Smee;Kevin W. Bailey;Min-Hui Wong;Barry R. O’Keefe

  • Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

    Joanna Sztuba-Solinska;Shilpa R. Shenoy;Peter Gareiss;Lauren R. H. Krumpe

  • Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

    Yutaka Takebe;Carrie J. Saucedo;Garry Lund;Rie Uenishi

  • Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins

    Shilpa R. Shenoy;Barry R. O'Keefe;Anders J. Bolmstedt;Laura K. Cartner

  • Creating and screening natural product libraries

    Brice A P Wilson;Christopher C Thornburg;Curtis J Henrich;Tanja Grkovic

  • Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

    Myriam Witvrouw;Valery Fikkert;Anke Hantson;Christophe Pannecouque

Frequent Co-Authors

James B. McMahon
James B. McMahon National Institutes of Health
John A. Beutler
John A. Beutler National Institutes of Health
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Kirk R. Gustafson
Kirk R. Gustafson National Institutes of Health
Michael R. Boyd
Michael R. Boyd University of South Alabama
Michael R. Boyd
Michael R. Boyd National Cancer Institute
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Alexander Wlodawer
Alexander Wlodawer National Institutes of Health
Christophe Marchand
Christophe Marchand National Institutes of Health
Yves Pommier
Yves Pommier National Institutes of Health

External Links

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Best Scientists Citing Barry R. O'Keefe

Peter H. Seeberger

Peter H. Seeberger

Max Planck Society

Publications: 53

Angela M. Gronenborn

Angela M. Gronenborn

University of Pittsburgh

Publications: 44

Dominique Schols

Dominique Schols

KU Leuven

Publications: 35

Jan Balzarini

Jan Balzarini

KU Leuven

Publications: 33

Olga I. Lavrik

Olga I. Lavrik

Russian Academy of Sciences

Publications: 27

Yves Pommier

Yves Pommier

National Institutes of Health

Publications: 22

Carole A. Bewley

Carole A. Bewley

National Institutes of Health

Publications: 22

Chi-Huey Wong

Chi-Huey Wong

Scripps Research Institute

Publications: 21

Christophe Marchand

Christophe Marchand

National Institutes of Health

Publications: 16

Irwin M. Chaiken

Irwin M. Chaiken

Drexel University

Publications: 12

Els J. M. Van Damme

Els J. M. Van Damme

Ghent University

Publications: 12

Dennis R. Burton

Dennis R. Burton

Scripps Research Institute

Publications: 11

Mark Cushman

Mark Cushman

Purdue University West Lafayette

Publications: 11

Michael R. Boyd

Michael R. Boyd

National Cancer Institute

Publications: 11

Matthew D. Disney

Matthew D. Disney

Scripps Research Institute

Publications: 10

William Furey

William Furey

University of Pittsburgh

Publications: 10

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