World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
46
Citations
8219
World Ranking
15995
National Ranking
3995

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John A. Beutler is affiliated with the National Institutes of Health in the United States. Their research spans several scientific fields with a primary focus on biochemistry, genetics, and molecular biology, along with significant contributions to medicine.

The scientist's work mainly addresses molecular biology, pharmacology, and organic chemistry, alongside specialized areas such as plant science and cell biology.

The research topics covered by John A. Beutler include:

  • Microbial natural products and biosynthesis
  • Phytochemical compounds biological activities
  • Plant biochemistry and biosynthesis
  • Plant pathogens and fungal diseases
  • Computational drug discovery methods
  • Fungal biology and applications
  • Plant chemical constituents analysis

John A. Beutler has published extensively in multiple scientific journals. Frequent publication venues include:

  • Journal of Natural Products
  • Molecules
  • Records of Natural Products
  • ACS Medicinal Chemistry Letters
  • The Journal of Organic Chemistry

Frequent co-authors collaborating with John A. Beutler are:

  • Barry R. O'Keefe
  • Ekaterina I. Goncharova
  • Dongdong Wang
  • Sarath P. D. Senadeera
  • Jennifer A. Wilson

The scientist's notable recent papers include:

  • A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells (2021), published in Cells
  • Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp. (2021), published in Organic Letters
  • Cytotoxic Sesquiterpene Coumarins from the Roots of Heptaptera cilicica (2021), published in Records of Natural Products
  • Beyond traditional screening: Unveiling antibiotic potentials of actinomycetes in extreme environments (2024), published in Heliyon
  • Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum (2022), published in Journal of Natural Products

John A. Beutler was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

    Yili Yang;Jirouta Kitagaki;Ren-Ming Dai;Yien Che Tsai

  • Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp.

    Karen L. Erickson;John A. Beutler;John H. Cardellina;Michael R. Boyd

  • Natural Products as a Foundation for Drug Discovery

    John A. Beutler

  • Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

    Ranjala Ratnayake;David Covell;Tanya T Ransom;Kirk R Gustafson

  • A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

    Kirk R. Gustafson;John H. Cardellina;James B. McMahon;Robert J. Gulakowski

  • Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

    Scott R. Budihas;Inna Gorshkova;Sergei Gaidamakov;Antony Wamiru

  • Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs

    Yoshihiro Mimaki;Minpei Kuroda;Aiko Kameyama;Yutaka Sashida

  • Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.

    Michael R. Boyd;Carlo Farina;Pietro Belfiore;Stefania Gagliardi

  • The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices.

    Schaufelberger De;Koleck Mp;Beutler Ja;Vatakis Am

  • Structure-activity requirements for flavone cytotoxicity and binding to tubulin

    John A. Beutler;Ernest Hamel;Arnold J. Vlietinck;Achiel Haemers

  • A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

    Michael A Parniak;Kyung-Lyum Min;Scott R Budihas;Stuart F.J Le Grice

  • Cytotoxic geranyl stilbenes from Macaranga schweinfurthii

    John A. Beutler;Robert H. Shoemaker;Tanya Johnson;Michael R. Boyd

  • 1H- and 13C-nmr Assignments for Taxol, 7-epi-Taxol, and Cephalomannine

    Gwendolyn N. Chmurny;Bruce D. Hilton;Susan Brobst;Sally A. Look

  • Securinine alkaloids: a new class of GABA receptor antagonist.

    J.A. Beutler;E.W. Karbon;A.N. Brubaker;R. Malik

  • Matching the power of high throughput screening to the chemical diversity of natural products

    Curtis J. Henrich;Curtis J. Henrich;John A. Beutler

  • Natural Products as a Foundation for Drug Discovery

    Unknown

  • A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts.

    H I I John Cardellina;Murray H. G. Munro;Richard W. Fuller;Kirk P. Manfredi

  • Tannic Acid Is an Inhibitor of CXCL12 (SDF-1α)/CXCR4 with Antiangiogenic Activity

    Xin Chen;John A. Beutler;Thomas G. McCloud;Amy Loehfelm

  • Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity

    Mei-Chih Liang;Sujata Bardhan;Emily A. Pace;Diana Rosman

  • Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization

    John A. Beutler;John H. Cardellina;Chii M. Lin;Ernest Hamel

  • A Novel Phorbol Ester from Excoecaria agallocha

    K. L. Erickson;J. A. Beutler;J. H. Cardellina;J. B. Mcmahon

  • Novel cytotoxic diterpenes from Casearia arborea.

    John A. Beutler;Kate L. McCall;Kathryn Herbert;Delbert L. Herald

Frequent Co-Authors

James B. McMahon
James B. McMahon National Institutes of Health
Michael R. Boyd
Michael R. Boyd University of South Alabama
Kirk R. Gustafson
Kirk R. Gustafson National Institutes of Health
Barry R. O'Keefe
Barry R. O'Keefe National Institutes of Health
John H. Cardellina
John H. Cardellina Montana State University
David F. Wiemer
David F. Wiemer University of Iowa
Michael R. Boyd
Michael R. Boyd National Cancer Institute
John A. Porco
John A. Porco Boston University
Robert H. Shoemaker
Robert H. Shoemaker National Institutes of Health
Nancy H. Colburn
Nancy H. Colburn National Institutes of Health

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