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Biology and Biochemistry

D-Index
106
Citations
59023
World Ranking
1129
National Ranking
673

Overview

Michael R. Boyd is affiliated with the National Cancer Institute in the United States. Their research spans several interrelated fields, primarily focusing on medicine and biochemistry, genetics, and molecular biology. Within these areas, they have contributed notably to oncology, molecular biology, immunology, polymers and plastics, and pharmacology.

Their work covers a range of topics including peptidase inhibition and analysis, biochemical and molecular research, pancreatic and hepatic oncology research, phosphodiesterase function and regulation, inflammatory mediators and NSAID effects, mast cells and histamine, and cancer immunotherapy and biomarkers.

Michael R. Boyd has published in several scientific journals, with frequent appearances in these venues:

  • Journal of Clinical Oncology
  • Drug Discovery Today
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Rubber Chemistry and Technology

Notable recent publications by Boyd include:

  • "CHARACTERIZATION AND CORRELATION OF THE NETWORK CHAIN DENSITY TO THE PROPERTIES OF FLUOROELASTOMER RUBBER," 2020, Rubber Chemistry and Technology
  • "PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity," 2020, Drug Discovery Today
  • "A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer," 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • "A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer," 2024, Cancer Research
  • "A potent and selective pan-RAS inhibitor, ADT-1004, targeting complex KRAS mutations for pancreatic cancer," 2024, Journal of Clinical Oncology

Frequent collaborative partners in their research include:

  • Gary A. Piazza
  • Donald J. Buchsbaum
  • Adam B. Keeton
  • Yulia Maxuitenko
  • Jeremy B. Foote

The overall focus of Boyd's research is characterized by an emphasis on oncology and molecular mechanisms underlying cancer and therapeutic targets. This includes detailed investigations into pancreatic and hepatic cancers, as well as signaling pathways that affect tumor growth and immunity. Their work also intersects with studies on polymers, as indicated by publications related to fluoroelastomer rubber, which signals a multidisciplinary approach integrating material science and biomedical research.

Best Publications

  • New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

    Philip Skehan;Ritsa Storeng;Dominic Scudiero;Anne Monks

  • Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

    Anne Monks;Dominic Scudiero;Philip Skehan;Robert Shoemaker

  • Some Practical Considerations and Applications of the National Cancer Institute In Vitro Anticancer Drug Discovery Screen

    Michael R. Boyd;Kenneth D. Paull

  • Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm

    K. D. Paull;R. H. Shoemaker;L. Hodes;A. Monks

  • Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines

    L. V. Rubinstein;R. H. Shoemaker;K. D. Paull;R. M. Simon

  • New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

    Owen S. Weislow;Rebecca Kiser;Donald L. Fine;John Bader

  • Tetrazolium-based Assays for Cellular Viability: A Critical Examination of Selected Parameters Affecting Formazan Production

    David T. Vistica;Philip Skehan;Dominic Scudiero;Anne Monks

  • Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

    M R Boyd;K R Gustafson;J B McMahon;R H Shoemaker

  • The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.

    Yoel Kashman;Kirk R. Gustafson;Richard W. Fuller;John H. Cardellina

  • Vaccine protection against Zika virus from Brazil

    Rafael A. Larocca;Peter Abbink;Jean Pierre S. Peron;Paolo M. de A. Zanotto

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

    Peter Abbink;Rafael A. Larocca;Rafael A. De La Barrera;Christine A. Bricault

  • Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung.

    Michael R. Boyd

  • Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.

    Toshiyuki Mori;Barry R. O'Keefe;Raymond C. Sowder;Scott Bringans

  • Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

    Theodore L. McLemore;Steven Adelberg;Mark C. Liu;Noreen A. McMahon

  • Rapid development of a DNA vaccine for Zika virus

    Kimberly A. Dowd;Sung-Youl Ko;Kaitlyn M. Morabito;Eun Sung Yang

  • Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.

    Joseph Kulkosky;Derek M. Culnan;Jeanette Roman;Geethanjali Dornadula

  • Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia.

    Kirk R. Gustafson;Raymond C. Sowder;Louis E. Henderson;Ian C. Parsons

  • Isolation and Structure of Spongistatin 1

    George R. Pettit;Zbigniew A. Cichacz;Cherry L. Herald

  • Antineoplastic agents. 379. Synthesis of phenstatin phosphate.

    George R. Pettit;Brian Toki;Delbert L. Herald;Pascal Verdier-Pinard

Frequent Co-Authors

John H. Cardellina
John H. Cardellina Montana State University
James B. McMahon
James B. McMahon National Institutes of Health
Kirk R. Gustafson
Kirk R. Gustafson National Institutes of Health
Dan H. Barouch
Dan H. Barouch Harvard Medical School
Vijayalakshmi Ravindranath
Vijayalakshmi Ravindranath Indian Institute of Science
Robert H. Shoemaker
Robert H. Shoemaker National Institutes of Health
Peter Abbink
Peter Abbink Harvard Medical School
Gerhard Bringmann
Gerhard Bringmann University of Würzburg
Lewis K. Pannell
Lewis K. Pannell National Institutes of Health
John A. Beutler
John A. Beutler National Institutes of Health

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