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Chemistry

D-Index
60
Citations
12186
World Ranking
9742
National Ranking
2740

Overview

Kirk R. Gustafson is affiliated with the National Institutes of Health in the United States. Their research contributions span multiple fields including biochemistry, genetics and molecular biology, medicine, and chemistry. Within these broad areas, their work focuses on molecular biology, pharmacology, biotechnology, organic chemistry, and cancer research.

The scientist has published extensively on topics related to marine sponges and natural products, microbial natural products and biosynthesis, synthetic organic chemistry methods, chemical synthesis and analysis, plant biochemistry and biosynthesis, synthesis and biological activity, as well as chemical synthesis and alkaloids.

Frequent publication venues for their research include:

  • Journal of Natural Products
  • Organic Letters
  • Molecules
  • Marine Drugs
  • Natural Product Reports

Notable recent papers by Kirk R. Gustafson include:

  • "Sesterterpenoids: chemistry, biology, and biosynthesis," 2020, Natural Product Reports
  • "National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library," 2020, ACS Chemical Biology
  • "Denigrins and Dactylpyrroles, Arylpyrrole Alkaloids from a Dactylia sp. Marine Sponge," 2020, Journal of Natural Products
  • "A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells," 2021, Cells
  • "Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I," 2020, Journal of the American Chemical Society

The researcher has collaborated frequently with several co-authors, including:

  • Dongdong Wang
  • Barry R. O'Keefe
  • Heidi R. Bokesch
  • Chang-Kwon Kim
  • Wei Jiang

Their work intersects multiple scientific disciplines with an emphasis on natural product chemistry, especially concerning marine-derived compounds and bioactive molecules. This interdisciplinary approach integrates synthetic organic chemistry methods and biological evaluation to explore novel chemical entities with potential applications in pharmacology and cancer research.

Best Publications

  • Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

    M R Boyd;K R Gustafson;J B McMahon;R H Shoemaker

  • The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.

    Yoel Kashman;Kirk R. Gustafson;Richard W. Fuller;John H. Cardellina

  • AIDS-Antiviral Sulfolipids From Cyanobacteria (Blue-Green Algae)

    Kirk R. Gustafson;John H. Cardellina;Richard W. Fuller;Owen S. Weislow

  • Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia.

    Kirk R. Gustafson;Raymond C. Sowder;Louis E. Henderson;Ian C. Parsons

  • Solution structure of cyanovirin-N, a potent HIV-inactivating protein

    C A Bewley;K R Gustafson;M R Boyd;D G Covell

  • The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea

    Kirk R. Gustafson;John W. Blunt;Murray H.G. Munro;Richard W. Fuller

  • PAPUAMIDES A-D, HIV-INHIBITORY AND CYTOTOXIC DEPSIPEPTIDES FROM THE SPONGES THEONELLA MIRABILIS AND THEONELLA SWINHOEI COLLECTED IN PAPUA NEW GUINEA

    R.W.M. van Soest;P.W. Ford;K.R. Gustafson;T.C. Mc Kee

  • Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

    Ranjala Ratnayake;David Covell;Tanya T Ransom;Kirk R Gustafson

  • A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

    Kirk R. Gustafson;John H. Cardellina;James B. McMahon;Robert J. Gulakowski

  • Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

    Barry R. O'Keefe;Donald F. Smee;Jim A. Turpin;Carrie J. Saucedo

  • Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans

    François Helle;Czeslaw Wychowski;Ngoc Vu-Dac;Kirk R. Gustafson

  • Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

    Conan K L Wang;Michelle L Colgrave;Kirk R Gustafson;David C Ireland

  • Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.

    McKee Tc;Bokesch Hr;McCormick Jl;Rashid Ma

  • Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.

    Fan Yang;Carole A Bewley;John M Louis;Kirk R Gustafson

  • Anti-HIV cyclotides.

    Kirk R. Gustafson;Tawnya C. McKee;Heidi R. Bokesch

  • Cyclotides as natural anti-HIV agents.

    David C. Ireland;Conan K. L. Wang;Jennifer A. Wilson;Kirk R. Gustafson

  • Marine pharmacology in 2001–2: antitumour and cytotoxic compounds

    Unknown

  • Marine pharmacology in 2000: Antitumor and cytotoxic compounds

    Unknown

  • Isolation and characterization of novel cyclotides from Viola hederaceae : Solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide

    Bin Chen;Bin Chen;Michelle L. Colgrave;Norelle L. Daly;K. Johan Rosengren

  • The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1.

    Norelle L. Daly;Kirk R. Gustafson;David J. Craik

  • Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi.

    Naoya Oku;Kirk R. Gustafson;Laura K. Cartner;Jennifer A. Wilson

  • Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity

    Norelle L Daly;Anita Koltay;Kirk R Gustafson;Michael R Boyd

  • New circulin macrocyclic polypeptides from Chassalia parvifolia.

    Kirk R. Gustafson;Linda K. Walton;Raymond C. Sowder;Donald G. Johnson

Frequent Co-Authors

John H. Cardellina
John H. Cardellina Montana State University
James B. McMahon
James B. McMahon National Institutes of Health
Lewis K. Pannell
Lewis K. Pannell National Institutes of Health
Michael R. Boyd
Michael R. Boyd University of South Alabama
Michael R. Boyd
Michael R. Boyd National Cancer Institute
John A. Beutler
John A. Beutler National Institutes of Health
Yoel Kashman
Yoel Kashman Tel Aviv University
Barry R. O'Keefe
Barry R. O'Keefe National Institutes of Health
Nancy H. Colburn
Nancy H. Colburn National Institutes of Health
Robert H. Shoemaker
Robert H. Shoemaker National Institutes of Health

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