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D-Index & Metrics

Chemistry

D-Index
72
Citations
18243
World Ranking
5257
National Ranking
1640

Overview

John A. Porco is affiliated with Boston University in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular biology and organic chemistry as prominent subfields.

Their recent scholarly output includes significant contributions to a range of scientific journals. Notable papers authored or co-authored by Porco include:

  • Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer, 2020, Nature Communications
  • Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F, 2020, Cell Reports
  • BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling, 2022, Nature Communications
  • An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris, 2020, Nature Communications
  • Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids, 2020, Angewandte Chemie International Edition

Porco frequently publishes in highly specialized venues, with repeat contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database
  • The Journal of Organic Chemistry
  • Nature Communications
  • Cell Reports

Their research extends over multiple main topics including phytochemical compounds and their biological activities, plant biochemistry and biosynthesis, RNA modifications and cancer, along with crystallization and solubility studies. Other key subjects involve X-ray diffraction techniques in crystallography, synthetic organic chemistry methods, and RNA and protein synthesis mechanisms.

Collaborations form an integral part of Porco's research, reflected by frequent co-authors such as Lauren E. Brown, Jerry Pelletier, Wenhan Zhang, Regina Cencic, and Luke Whitesell.

With a publication record featuring a total of 53 works in biochemistry, genetics, and molecular biology, and 36 in medicine, Porco contributes mainly to the fields of molecular biology, organic chemistry, plant science, materials chemistry, and pharmacology. Their multidisciplinary approach encompasses experimental and theoretical perspectives within these areas.

Best Publications

  • Dearomatization Strategies in the Synthesis of Complex Natural Products

    Stéphane P. Roche;John A. Porco

  • Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

    Markus D. Kärkäs;John A. Porco;Corey R. J. Stephenson

  • Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities

    James K. Harper;Atta M. Arif;Eugene J. Ford;Gary A. Strobel

  • How proteins bind macrocycles

    Elizabeth A Villar;Dmitri Beglov;Spandan Chennamadhavuni;John A Porco

  • Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.

    Marie-Eve Bordeleau;Francis Robert;Baudouin Gerard;Lisa Lindqvist

  • Enzyme-Catalyzed Aldol Condensation for Asymmetric-Synthesis of Azasugars - Synthesis, Evaluation, and Modeling of Glycosidase Inhibitors

    Tetsuya Kajimoto;Kevin K. C. Liu;Richard L. Pederson;Ziyang Zhong

  • Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

    Sandro Santagata;Marc L. Mendillo;Yun Chi Tang;Yun Chi Tang;Aravind Subramanian

  • Synthesis of enamides related to the salicylate antitumor macrolides using copper-mediated vinylic substitution

    Ruichao Shen;John A. Porco

  • Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

    Ancy D. Nalli;Lauren E. Brown;Cheryl L. Thomas;Thomas J. Sayers

  • Desaromatisierungsstrategien in der Synthese strukturell komplexer Naturstoffe

    Stéphane P. Roche;John A. Porco

  • Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors

    Chi-Huey Wong;Louis Provencher;John A. Porco;Sang-Hun Jung

  • Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes

    Jianglong Zhu;Andrew R. Germain;John A. Porco

  • Transannular Diels-Alder route to systems related to dynemicin A

    John A. Porco;Frank J. Schoenen;Thomas J. Stout;Jon Clardy

  • Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes.

    Chong Han;Jonathan P. Lee;Emil Lobkovsky;John A. Jr. Porco

  • Discovery of chemical reactions through multidimensional screening.

    Aaron B. Beeler;Shun Su;Chris A. Singleton;John A. Porco

  • Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade.

    Chaomin Li;Richard P. Johnson;John A. Porco

  • Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies

    Ruichao Shen;Cheng Ting Lin;Emma Jean Bowman;Barry J. Bowman

  • Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.

    Nava Zaarur;Vladimir L. Gabai;John A. Porco;Stuart Calderwood

  • Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes

    Baudouin Gerard;Jamie Ryan;Aaron B. Beeler;John A. Porco

  • Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerization/Dipolar Cycloaddition

    Shun Su;John A. Porco

Frequent Co-Authors

Jerry Pelletier
Jerry Pelletier McGill University
Scott E. Schaus
Scott E. Schaus Boston University
James S. Panek
James S. Panek Boston University
Jon Clardy
Jon Clardy Harvard University
John A. Beutler
John A. Beutler National Institutes of Health
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Corey R. J. Stephenson
Corey R. J. Stephenson University of Michigan–Ann Arbor
Thomas D. Gilmore
Thomas D. Gilmore Boston University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center

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