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Molecular Biology

D-Index
65
Citations
13727
World Ranking
1678
National Ranking
848

Overview

Joel M. Gottesfeld is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with additional contributions to neuroscience and medicine.

Their scholarly work includes studies in several subfields, notably cellular and molecular neuroscience, molecular biology, cell biology, geriatrics and gerontology, as well as pulmonary and respiratory medicine.

The scientist focuses on key research topics including genetic neurodegenerative diseases, mitochondrial function and pathology, DNA repair mechanisms, endoplasmic reticulum stress and disease, sirtuins and resveratrol in medicine, and advances in cystic fibrosis research.

Joel M. Gottesfeld has published multiple recent papers, which include:

  • Methylated and unmethylated epialleles support variegated epigenetic silencing in Friedreich ataxia (2020), published in Human Molecular Genetics
  • A non-synonymous single nucleotide polymorphism in SIRT6 predicts neurological severity in Friedreich ataxia (2022), published in Frontiers in Molecular Biosciences
  • Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis (2020), published in UNC Libraries

Their collaborations involve frequent co-authors such as Layne N. Rodden, Elisabetta Soragni, David R. Lynch, Yogesh K. Chutake, and Kaitlyn M. Gilliam.

Publication venues where Joel M. Gottesfeld has contributed notably include Human Molecular Genetics, Frontiers in Molecular Biosciences, and UNC Libraries.

Best Publications

  • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.

    Louise C. Laurent;Louise C. Laurent;Igor Ulitsky;Igor Ulitsky;Ileana Slavin;Ha Tran

  • Regulation of gene expression by small molecules

    Joel M. Gottesfeld;Laura Neely;John W. Trauger;Eldon E. Baird

  • Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

    David Herman;Kai Jenssen;Ryan Burnett;Elisabetta Soragni

  • Mitotic repression of the transcriptional machinery

    Joel M. Gottesfeld;Douglass J. Forbes

  • Zinc finger protein derivatives and methods therefor

    Carlos F. Barbas;Joel M. Gottesfeld;Peter E. Wright

  • Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands.

    Liliane A. Dickinson;Richard J. Gulizia;John W. Trauger;Eldon E. Baird

  • The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

    Elizabeth A. Thomas;Giovanni Coppola;Paula A. Desplats;Bin Tang

  • Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

    Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel

  • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

    Myriam Rai;Elisabetta Soragni;Kai Jenssen;Ryan Burnett

  • Partial purification of the template-active fraction of chromatin: a preliminary report.

    J. M. Gottesfeld;W. T. Garrard;G. Bagi;R. F. Wilson

  • Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity.

    Deborah S. Wuttke;Mark P. Foster;David A. Case;Joel M. Gottesfeld

  • Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.

    C. James Chou;David M. Herman;Joel M. Gottesfeld

  • Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA⋅TTC Triplet Repeat Instability

    Sherman Ku;Elisabetta Soragni;Erica Campau;Elizabeth A. Thomas

  • Assembly of transcriptionally active 5S RNA gene chromatin in vitro.

    Joel Gottesfeld;Laureen S. Bloomer

  • Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands

    Robert K. Suto;Rajeswari S. Edayathumangalam;Cindy L. White;Christian Melander

  • Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.

    Mark P. Foster;Deborah S. Wuttke;Deborah S. Wuttke;Ishwar Radhakrishnan;David A. Case

  • Molecular basis for specific recognition of both RNA and DNA by a zinc finger protein

    Karen R. Clemens;Veronica Wolf;Steven J. McBryant;Penghua Zhang

  • Epigenetic therapy for Friedreich ataxia

    Elisabetta Soragni;Wenyan Miao;Marco Iudicello;David Jacoby

  • Identifier sequences are transcribed specifically in brain

    J. Gregor Sutcliffe;Robert J. Milner;Joel M. Gottesfeld;Richard A. Lerner

  • Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

    Haiqun Jia;Judit Pallos;Vincent Jacques;Alice Lau

Frequent Co-Authors

Peter B. Dervan
Peter B. Dervan California Institute of Technology
Christian Melander
Christian Melander University of Notre Dame
Peter E. Wright
Peter E. Wright Scripps Research Institute
Eldon E. Baird
Eldon E. Baird California Institute of Technology
Karolin Luger
Karolin Luger University of Colorado Boulder
Massimo Pandolfo
Massimo Pandolfo McGill University
James Bonner
James Bonner California Institute of Technology
Giovanni Coppola
Giovanni Coppola University of California, Los Angeles
David P. Bazett-Jones
David P. Bazett-Jones University of Calgary
Carlos F. Barbas
Carlos F. Barbas Scripps Research Institute

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