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Shigetsugu Hatakeyama

Shigetsugu Hatakeyama

Hokkaido University
Japan

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
22096
World Ranking
6557
National Ranking
427

Shigetsugu Hatakeyama publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Shigetsugu Hatakeyama sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 182 publications — 42nd percentile

42% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Shigetsugu Hatakeyama D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Shigetsugu Hatakeyama sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 71 D-Index — 67th percentile

67% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Shigetsugu Hatakeyama is a researcher affiliated with Hokkaido University in Japan, specializing in fields related to Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work spans 24 publications in Biochemistry, Genetics, and Molecular Biology and 23 publications in Medicine, highlighting a multidisciplinary approach to scientific investigation.

Their subfields of study include Molecular Biology, Immunology, Oncology, Physiology, and Epidemiology, with the largest focus on Molecular Biology, covering 19 publications. Other significant areas include Immunology with 9 publications and Oncology with 6 publications.

The main research topics addressed by Hatakeyama encompass

  • Ubiquitin and proteasome pathways
  • Immunotherapy and Immune Responses
  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Cancer-related Molecular Pathways
  • Immune Cell Function and Interaction
  • Protein Degradation and Inhibitors

Hatakeyama has contributed frequently to several scientific journals. Notable publication venues include

  • Nature Communications (2 papers)
  • Biochemical and Biophysical Research Communications (2 papers)
  • European Urology (2 papers)
  • Cell (1 paper)
  • Proceedings of the National Academy of Sciences (1 paper)

Selected recent papers by Hatakeyama demonstrate a range of biological and medical research themes:

  • "RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis," published in 2020 in Cell
  • "A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis," published in 2020 in Nature Communications
  • "Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases," published in 2020 in Allergology International
  • "A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets," published in 2020 in Communications Biology
  • "The role of Mediator and Little Elongation Complex in transcription termination," published in 2020 in Nature Communications

Collaborative work is an essential component of Hatakeyama's research, with frequent coauthors including Masashi Watanabe (9 collaborations), Hidehisa Takahashi (5 collaborations), Akira Nakazono (4 collaborations), and Takeshi Kondo (7 collaborations combined, listed under two entries).

Best Publications

  • RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

    Kevin L. Lorick;Jane P. Jensen;Shengyun Fang;Albert M. Ong

  • TRIM proteins and cancer

    Shigetsugu Hatakeyama

  • Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.

    Masayoshi Yada;Shigetsugu Hatakeyama;Takumi Kamura;Masaaki Nishiyama

  • Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

    Keiko Nakayama;Hiroyasu Nagahama;Yohji A. Minamishima;Masaki Matsumoto

  • TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

    Shigetsugu Hatakeyama

  • An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

    Masatoshi Kitagawa;Shigetsugu Hatakeyama;Michiko Shirane;Masaki Matsumoto

  • U Box Proteins as a New Family of Ubiquitin-Protein Ligases

    Shigetsugu Hatakeyama;Masayoshi Yada;Masaki Matsumoto;Noriko Ishida

  • Essential role for ZAP-70 in both positive and negative selection of thymocytes

    Izumi Negishi;Izumi Negishi;Izumi Negishi;Noboru Motoyama;Kei Ichi Nakayama;Kei Ichi Nakayama;Kei Ichi Nakayama;Keiko Nakayama;Keiko Nakayama;Keiko Nakayama

  • CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

    Yuzuru Imai;Mariko Soda;Shigetsugu Hatakeyama;Takumi Akagi

  • NAK is an IκB kinase-activating kinase

    Yuichiro Tojima;Atsushi Fujimoto;Mireille Delhase;Yi Chen

  • Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

    Takumi Kamura;Taichi Hara;Masaki Matsumoto;Noriko Ishida

  • Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

    Akitomo Miyamoto;Keiko Nakayama;Hiroyuki Imaki;Sachiko Hirose

  • Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

    Hiroyuki Oshiumi;Misako Matsumoto;Shigetsugu Hatakeyama;Tsukasa Seya

  • Skp2-mediated degradation of p27 regulates progression into mitosis.

    Keiko Nakayama;Hiroyasu Nagahama;Yohji A. Minamishima;Satoshi Miyake

  • The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

    Shintaro Kamizono;Toshikatsu Hanada;Hideo Yasukawa;Shigeru Minoguchi

  • Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

    Ryosuke Tsunematsu;Keiko Nakayama;Yuichi Oike;Masaaki Nishiyama

  • Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

    Takumi Kamura;Taichi Hara;Shuhei Kotoshiba;Masayoshi Yada

  • Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1

    Kei Ichi Nakayama;Shigetsugu Hatakeyama;Keiko Nakayama

  • Down-regulation of p27 Kip1 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

    Michiko Shirane;Yumiko Harumiya;Noriko Ishida;Aizan Hirai

  • U-box proteins as a new family of ubiquitin ligases

    Shigetsugu Hatakeyama;Kei Ichi I. Nakayama

Frequent Co-Authors

Keiichi I. Nakayama
Keiichi I. Nakayama Institute of Science Tokyo
Shinya Tanaka
Shinya Tanaka Hokkaido University
Masatoshi Kitagawa
Masatoshi Kitagawa Hamamatsu University
Joan Weliky Conaway
Joan Weliky Conaway The University of Texas Southwestern Medical Center
Ronald C. Conaway
Ronald C. Conaway The University of Texas Southwestern Medical Center
Hiroyuki Tsutsui
Hiroyuki Tsutsui Kyushu University
Keiko Nakayama
Keiko Nakayama Tohoku University
Dennis Y. Loh
Dennis Y. Loh Washington University in St. Louis
Michael P. Washburn
Michael P. Washburn University of Kansas
Hisashi Arase
Hisashi Arase Osaka University

External Links

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Best Scientists Citing Shigetsugu Hatakeyama

Keiichi I. Nakayama

Keiichi I. Nakayama

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Publications: 160

Michele Pagano

Michele Pagano

New York University

Publications: 50

Keiko Nakayama

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Tohoku University

Publications: 45

Wenyi Wei

Wenyi Wei

Beth Israel Deaconess Medical Center

Publications: 35

Allan M. Weissman

Allan M. Weissman

National Institutes of Health

Publications: 35

Akira Kikuchi

Akira Kikuchi

Osaka University

Publications: 34

Akihiko Yoshimura

Akihiko Yoshimura

Keio University

Publications: 34

Masatoshi Kitagawa

Masatoshi Kitagawa

Hamamatsu University

Publications: 33

Hui Kuan Lin

Hui Kuan Lin

Wake Forest University

Publications: 32

Andreas Strasser

Andreas Strasser

Walter and Eliza Hall Institute of Medical Research

Publications: 32

Keiji Tanaka

Keiji Tanaka

Tokyo Metropolitan Institute of Medical Science

Publications: 31

Yi Sun

Yi Sun

Zhejiang University

Publications: 31

Hiroyuki Oshiumi

Hiroyuki Oshiumi

Kumamoto University

Publications: 31

Arthur Weiss

Arthur Weiss

University of California, San Francisco

Publications: 31

Bruce E. Clurman

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Fred Hutchinson Cancer Research Center

Publications: 29

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Nicos A. Nicola

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