Shigetsugu Hatakeyama mainly focuses on Ubiquitin, Ubiquitin ligase, Cell biology, Molecular biology and Biochemistry. His work deals with themes such as Hsp70, Neurodegeneration, Protein degradation and Proteasome, which intersect with Ubiquitin. His Cell biology study integrates concerns from other disciplines, such as Cell division control protein 4, Cyclin-dependent kinase, Cell cycle, Mutant and Proteolysis.
His studies deal with areas such as SCF complex, Cell growth, F-box protein and Phosphorylation as well as Molecular biology. His work in Ring finger addresses subjects such as BARD1, which are connected to disciplines such as RING finger domain. His Tripartite motif family research includes elements of Cancer research and TRIM24.
Shigetsugu Hatakeyama spends much of his time researching Cell biology, Ubiquitin, Molecular biology, Ubiquitin ligase and Biochemistry. His studies in Cell biology integrate themes in fields like Cell cycle, Embryonic stem cell and Neurodegeneration. The Ubiquitin study combines topics in areas such as Plasma protein binding, Mutant, Proteolysis and Proteasome.
His Molecular biology research includes themes of Cell division control protein 4, Protein kinase A, Transcription, Gene and Monocyte. His Ubiquitin ligase study combines topics in areas such as Cancer research and DNA ligase. His research investigates the link between Signal transduction and topics such as Phosphorylation that cross with problems in Kinase.
His primary areas of study are Cell biology, Ubiquitin ligase, Ubiquitin, Cancer research and Molecular biology. His Cell biology research integrates issues from Regulator and Transferrin receptor. His work deals with themes such as TRIM28, Adipogenesis and Phosphorylation, which intersect with Ubiquitin ligase.
In his study, which falls under the umbrella issue of Ubiquitin, Tripartite motif family is strongly linked to Proteasome. His Cancer research study incorporates themes from Gene knockdown, Immunoprecipitation, DNA methylation, Vimentin and Gene silencing. His Molecular biology study integrates concerns from other disciplines, such as Histone deacetylase, Antibody, Gene expression and Monocyte.
Cell biology, Ubiquitin ligase, Ubiquitin, Signal transduction and Proteasome are his primary areas of study. His Ubiquitin ligase research is multidisciplinary, incorporating elements of Beta-catenin, Frizzled, Wnt signaling pathway, LRP5 and PDZ domain. His study in the field of TRIM Family also crosses realms of Adipocyte.
His TRIM Family research includes themes of NFKB1, IκBα, Phosphorylation, Neddylation and Innate immune system. His Proteasome study improves the overall literature in Biochemistry. His study in Tripartite motif family is interdisciplinary in nature, drawing from both Autophagy, Tripartite Motif Proteins, Immunity, Regulator and Cell cycle.
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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Kevin L. Lorick;Jane P. Jensen;Shengyun Fang;Albert M. Ong.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication
Keiko Nakayama;Hiroyasu Nagahama;Yohji A. Minamishima;Masaki Matsumoto.
The EMBO Journal (2000)
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Masayoshi Yada;Shigetsugu Hatakeyama;Takumi Kamura;Masaaki Nishiyama.
The EMBO Journal (2004)
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
Masatoshi Kitagawa;Shigetsugu Hatakeyama;Michiko Shirane;Masaki Matsumoto.
The EMBO Journal (1999)
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
Shigetsugu Hatakeyama;Masayoshi Yada;Masaki Matsumoto;Noriko Ishida.
Journal of Biological Chemistry (2001)
TRIM proteins and cancer
Nature Reviews Cancer (2011)
Essential role for ZAP-70 in both positive and negative selection of thymocytes
Izumi Negishi;Izumi Negishi;Izumi Negishi;Noboru Motoyama;Kei Ichi Nakayama;Kei Ichi Nakayama;Kei Ichi Nakayama;Keiko Nakayama;Keiko Nakayama;Keiko Nakayama.
CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity
Yuzuru Imai;Mariko Soda;Shigetsugu Hatakeyama;Takumi Akagi.
Molecular Cell (2002)
NAK is an IκB kinase-activating kinase
Yuichiro Tojima;Atsushi Fujimoto;Mireille Delhase;Yi Chen.
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase
Takumi Kamura;Taichi Hara;Masaki Matsumoto;Noriko Ishida.
Nature Cell Biology (2004)
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