What is he best known for?
The fields of study he is best known for:
Shigetsugu Hatakeyama mainly focuses on Ubiquitin, Ubiquitin ligase, Cell biology, Molecular biology and Biochemistry.
His work deals with themes such as Hsp70, Neurodegeneration, Protein degradation and Proteasome, which intersect with Ubiquitin.
His Cell biology study integrates concerns from other disciplines, such as Cell division control protein 4, Cyclin-dependent kinase, Cell cycle, Mutant and Proteolysis.
His studies deal with areas such as SCF complex, Cell growth, F-box protein and Phosphorylation as well as Molecular biology.
His work in Ring finger addresses subjects such as BARD1, which are connected to disciplines such as RING finger domain.
His Tripartite motif family research includes elements of Cancer research and TRIM24.
His most cited work include:
- RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination (1005 citations)
- Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication (623 citations)
- Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. (570 citations)
What are the main themes of his work throughout his whole career to date?
Shigetsugu Hatakeyama spends much of his time researching Cell biology, Ubiquitin, Molecular biology, Ubiquitin ligase and Biochemistry.
His studies in Cell biology integrate themes in fields like Cell cycle, Embryonic stem cell and Neurodegeneration.
The Ubiquitin study combines topics in areas such as Plasma protein binding, Mutant, Proteolysis and Proteasome.
His Molecular biology research includes themes of Cell division control protein 4, Protein kinase A, Transcription, Gene and Monocyte.
His Ubiquitin ligase study combines topics in areas such as Cancer research and DNA ligase.
His research investigates the link between Signal transduction and topics such as Phosphorylation that cross with problems in Kinase.
He most often published in these fields:
- Cell biology (46.07%)
- Ubiquitin (35.39%)
- Molecular biology (33.71%)
What were the highlights of his more recent work (between 2013-2021)?
- Cell biology (46.07%)
- Ubiquitin ligase (29.21%)
- Ubiquitin (35.39%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Cell biology, Ubiquitin ligase, Ubiquitin, Cancer research and Molecular biology.
His Cell biology research integrates issues from Regulator and Transferrin receptor.
His work deals with themes such as TRIM28, Adipogenesis and Phosphorylation, which intersect with Ubiquitin ligase.
In his study, which falls under the umbrella issue of Ubiquitin, Tripartite motif family is strongly linked to Proteasome.
His Cancer research study incorporates themes from Gene knockdown, Immunoprecipitation, DNA methylation, Vimentin and Gene silencing.
His Molecular biology study integrates concerns from other disciplines, such as Histone deacetylase, Antibody, Gene expression and Monocyte.
Between 2013 and 2021, his most popular works were:
- TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis (254 citations)
- TRIM proteins and diseases. (78 citations)
- TRIM29 suppresses TWIST1 and invasive breast cancer behavior (45 citations)
In his most recent research, the most cited papers focused on:
Cell biology, Ubiquitin ligase, Ubiquitin, Signal transduction and Proteasome are his primary areas of study.
His Ubiquitin ligase research is multidisciplinary, incorporating elements of Beta-catenin, Frizzled, Wnt signaling pathway, LRP5 and PDZ domain.
His study in the field of TRIM Family also crosses realms of Adipocyte.
His TRIM Family research includes themes of NFKB1, IκBα, Phosphorylation, Neddylation and Innate immune system.
His Proteasome study improves the overall literature in Biochemistry.
His study in Tripartite motif family is interdisciplinary in nature, drawing from both Autophagy, Tripartite Motif Proteins, Immunity, Regulator and Cell cycle.
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