Shigetsugu Hatakeyama

Overview

Best Publications

• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

  Kevin L. Lorick;Jane P. Jensen;Shengyun Fang;Albert M. Ong

  1458
  Citations

• TRIM proteins and cancer

  Shigetsugu Hatakeyama

  923
  Citations

• Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.

  Masayoshi Yada;Shigetsugu Hatakeyama;Takumi Kamura;Masaaki Nishiyama

  915
  Citations

• Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

  Keiko Nakayama;Hiroyasu Nagahama;Yohji A. Minamishima;Masaki Matsumoto

  894
  Citations

• TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

  Shigetsugu Hatakeyama

  851
  Citations

• An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

  Masatoshi Kitagawa;Shigetsugu Hatakeyama;Michiko Shirane;Masaki Matsumoto

  728
  Citations

• U Box Proteins as a New Family of Ubiquitin-Protein Ligases

  Shigetsugu Hatakeyama;Masayoshi Yada;Masaki Matsumoto;Noriko Ishida

  716
  Citations

• Essential role for ZAP-70 in both positive and negative selection of thymocytes

  Izumi Negishi;Izumi Negishi;Izumi Negishi;Noboru Motoyama;Kei Ichi Nakayama;Kei Ichi Nakayama;Kei Ichi Nakayama;Keiko Nakayama;Keiko Nakayama;Keiko Nakayama

  667
  Citations

• CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

  Yuzuru Imai;Mariko Soda;Shigetsugu Hatakeyama;Takumi Akagi

  606
  Citations

• NAK is an IκB kinase-activating kinase

  Yuichiro Tojima;Atsushi Fujimoto;Mireille Delhase;Yi Chen

  500
  Citations

• Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

  Takumi Kamura;Taichi Hara;Masaki Matsumoto;Noriko Ishida

  492
  Citations

• Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

  Akitomo Miyamoto;Keiko Nakayama;Hiroyuki Imaki;Sachiko Hirose

  491
  Citations

• Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

  Hiroyuki Oshiumi;Misako Matsumoto;Shigetsugu Hatakeyama;Tsukasa Seya

  426
  Citations

• Skp2-mediated degradation of p27 regulates progression into mitosis.

  Keiko Nakayama;Hiroyasu Nagahama;Yohji A. Minamishima;Satoshi Miyake

  409
  Citations

• The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

  Shintaro Kamizono;Toshikatsu Hanada;Hideo Yasukawa;Shigeru Minoguchi

  384
  Citations

• Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

  Ryosuke Tsunematsu;Keiko Nakayama;Yuichi Oike;Masaaki Nishiyama

  360
  Citations

• Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

  Takumi Kamura;Taichi Hara;Shuhei Kotoshiba;Masayoshi Yada

  359
  Citations

• Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1

  Kei Ichi Nakayama;Shigetsugu Hatakeyama;Keiko Nakayama

  338
  Citations

• Down-regulation of p27 Kip1 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

  Michiko Shirane;Yumiko Harumiya;Noriko Ishida;Aizan Hirai

  334
  Citations

• U-box proteins as a new family of ubiquitin ligases

  Shigetsugu Hatakeyama;Kei Ichi I. Nakayama

  331
  Citations