Robert M. Krug

Research.com Recognitions

• 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

  Stephen J. Plotch;Michele Bouloy;Ismo Ulmanen;Robert M. Krug

  1015
  Citations

• Influenza Virus NS1 Protein Interacts with the Cellular 30 kDa Subunit of CPSF and Inhibits 3′ End Formation of Cellular Pre-mRNAs

  Martin E. Nemeroff;Silvia M.L. Barabino;Yongzhong Li;Walter Keller

  839
  Citations

• Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein

  Weiming Yuan;Robert M. Krug

  647
  Citations

• The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway

  Ji-Young Min;Robert M. Krug

  645
  Citations

• Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.

  Zhongying Chen;Yongzhong Li;Robert M. Krug

  598
  Citations

• Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor

  Yuan Lu;Marlene Wambach;Michael G. Katze;Robert M. Krug

  591
  Citations

• Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

  Chen Zhao;Carilee Denison;Jon M. Huibregtse;Steven Gygi

  561
  Citations

• The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA.

  Qiaozhen Ye;Robert M. Krug;Yizhi Jane Tao

  556
  Citations

• Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

  Shoudong Li;Ji Young Min;Robert M Krug;Ganes C. Sen;Ganes C. Sen

  460
  Citations

• Structures of influenza A proteins and insights into antiviral drug targets

  Kalyan Das;James M. Aramini;James M. Aramini;Li Chung Ma;Li Chung Ma;Robert M. Krug

  458
  Citations

• Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS.

  Diana L Noah;Karen Y Twu;Robert M Krug

  435
  Citations

• The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A).

  Yun Qiu;Robert M. Krug

  394
  Citations

• Intracellular warfare between human influenza viruses and human cells : the roles of the viral NS1 protein

  Robert M. Krug;Weiming Yuan;Diana L. Noah;Anita Ghate Latham

  390
  Citations

• Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

  R M Krug;M A Morgan;A J Shatkin

  381
  Citations

• A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.

  Ji Young Min;Shoudong Li;Ganes C. Sen;Robert M Krug

  379
  Citations

• The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein

  Chen Zhao;Sylvie L. Beaudenon;Melissa L. Kelley;M. Brett Waddell

  375
  Citations

• Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells

  Anahita Dastur;Sylvie Beaudenon;Melissa Kelley;Robert M. Krug

  372
  Citations

• Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription.

  Janet Braam;Ismo Ulmanen;Robert M. Krug

  363
  Citations

• Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription.

  Ismo Ulmanen;Barbara A. Broni;Robert M. Krug

  362
  Citations

• Globin mRNAs are primers for the transcription of influenza viral RNA in vitro

  Michele Bouloy;Stephen J. Plotch;Robert M. Krug

  358
  Citations