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Neuroscience

D-Index
82
Citations
33223
World Ranking
1490
National Ranking
741

Research.com Recognitions

  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2014 - Member of the National Academy of Sciences

Overview

Bruce P. Bean is affiliated with Harvard University in the United States. Their research spans several interconnected scientific disciplines, with a focus on medicine, neuroscience, and biochemistry, genetics, and molecular biology. Within these areas, their work particularly addresses molecular biology, cellular and molecular neuroscience, physiology, cardiology and cardiovascular medicine, and pharmacology.

The scientist's main research topics include:

  • Ion channel regulation and function
  • Neuroscience and neuropharmacology research
  • Cardiac electrophysiology and arrhythmias
  • Pain mechanisms and treatments
  • Neuroscience and neural engineering
  • Cannabis and cannabinoid research
  • Respiratory and cough-related research

Bruce P. Bean has contributed extensively to the scientific literature. Recent publications include:

  • "Cannabidiol inhibits Nav channels through two distinct binding sites," 2023, Nature Communications
  • "Developing nociceptor-selective treatments for acute and chronic pain," 2021, Science Translational Medicine
  • "Cannabidiol activates neuronal Kv7 channels," 2022, eLife
  • "Cannabidiol Inhibition of Murine Primary Nociceptors: Tight Binding to Slow Inactivated States of Nav1.8 Channels," 2021, Journal of Neuroscience
  • "BK Channel Regulation of Afterpotentials and Burst Firing in Cerebellar Purkinje Neurons," 2021, Journal of Neuroscience

Frequent co-authors collaborating with Bean include Sooyeon Jo, Clifford J. Woolf, Han-Xiong Bear Zhang, Akie Fujita, and Jaehoon Shim.

Their publications have appeared across various venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Pharmacology
  • Journal of Neuroscience
  • Proceedings of the National Academy of Sciences
  • The Journal of Physiology

Bruce P. Bean's professional recognitions include election as a Member of the National Academy of Sciences and as a Fellow of the American Academy of Arts and Sciences, both awarded in 2014.

Best Publications

  • The action potential in mammalian central neurons

    Bruce P. Bean

  • Classes of calcium channels in vertebrate cells

    Bruce P. Bean

  • Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

    Bruce P. Bean

  • Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

    Bruce P. Bean

  • Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

    James E. Huettner;Bruce P. Bean

  • P-type calcium channels in rat central and peripheral neurons

    Isabelle M. Mintz;Michael E. Adams;Bruce P. Bean

  • Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

    B P Bean

  • Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

    Indira M. Raman;Bruce P. Bean

  • Lidocaine block of cardiac sodium channels.

    Bruce P. Bean;Charles J. Cohen;Richard W. Tsien

  • Nociceptors are interleukin-1beta sensors

    Alexander M. Binshtok;Haibin Wang;Katharina Zimmermann;Fumimasa Amaya

  • Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

    Brian J. Wainger;Evangelos Kiskinis;Cassidy Mellin;Ole Wiskow

  • Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons.

    Indira M. Raman;Bruce P. Bean

  • A new conus peptide ligand for mammalian presynaptic Ca2+ channels

    David R. Hillyard;Virginia D. Monje;Isabelle M. Mintz;Bruce P. Bean

  • Ca2+ channels in rat central and peripheral neurons: High-threshold current resistant to dihydropyridine blockers and ω-conotoxin

    Laura J. Regan;Dinah W.Y. Sah;Bruce P. Bean

  • Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

    R W Tsien;B P Bean;P Hess;J B Lansman

  • Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

    Indira M Raman;Leslie K Sprunger;Miriam H Meisler;Bruce P Bean

  • Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers

    Alexander M. Binshtok;Bruce P. Bean;Clifford J. Woolf

  • Roles of Tetrodotoxin (TTX)-Sensitive Na+ Current, TTX-Resistant Na+ Current, and Ca2+ Current in the Action Potentials of Nociceptive Sensory Neurons

    Nathaniel T. Blair;Bruce P. Bean

  • Pharmacology and electrophysiology of ATP-activated ion channels

    Bruce P. Bean

  • Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons.

    Michelino Puopolo;Elio Raviola;Bruce P. Bean

  • Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons.

    Abraha Taddese;Bruce P Bean

  • Na+ channels must deactivate to recover from inactivation.

    Chung-Chin Kuo;Bruce P. Bean

Frequent Co-Authors

Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Seog Bae Oh
Seog Bae Oh Seoul National University
Indira M. Raman
Indira M. Raman Northwestern University
Elio Raviola
Elio Raviola Harvard University
Richard W. Tsien
Richard W. Tsien New York University
Marco Martina
Marco Martina Northwestern University
Bernardo L. Sabatini
Bernardo L. Sabatini Harvard Medical School
David D. Ginty
David D. Ginty Howard Hughes Medical Institute
Miriam H. Meisler
Miriam H. Meisler University of Michigan–Ann Arbor
Stefano Gustincich
Stefano Gustincich Italian Institute of Technology

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