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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
14386
World Ranking
10752
National Ranking
4671

Overview

Eduardo Perozo is affiliated with the University of Chicago in the United States. Their research output spans diverse topics within biochemistry, genetics, molecular biology, and neuroscience, emphasizing ion channel regulation and function.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Subfields in which they have published notably are:

  • Molecular Biology
  • Sensory Systems
  • Cardiology and Cardiovascular Medicine
  • Cellular and Molecular Neuroscience
  • Biomedical Engineering

The key topics covered in their work comprise:

  • Ion channel regulation and function
  • Hearing, Cochlea, Tinnitus, Genetics
  • Cardiac electrophysiology and arrhythmias
  • Lipid Membrane Structure and Behavior
  • Erythrocyte Function and Pathophysiology
  • Nanopore and Nanochannel Transport Studies
  • Neuroscience and Neural Engineering

Eduardo Perozo has published extensively in several scientific journals and venues. Their frequent publication venues include:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • eLife

Some recent papers authored or co-authored by Eduardo Perozo are:

  • The conformational cycle of prestin underlies outer-hair cell electromotility (2021, Nature)
  • Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1 (2020, Nature)
  • Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils (2021, Nature Communications)
  • Mechanism of C-type inactivation in the hERG potassium channel (2021, Science Advances)
  • Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel (2021, The Journal of General Physiology)

Their frequent co-authors, with whom they have collaborated multiple times, include:

  • Rong Shen
  • Navid Bavi
  • Gustavo F. Contreras
  • Bharat Reddy
  • Benoı̂t Roux

Best Publications

  • Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating

    Eduardo Perozo;Anna Kloda;D. Marien Cortes;Boris Martinac

  • Open channel structure of MscL and the gating mechanism of mechanosensitive channels

    Eduardo Perozo;D. Marien Cortes;Pornthep Sompornpisut;Pornthep Sompornpisut;Anna Kloda

  • Structural Rearrangements Underlying K+-Channel Activation Gating

    Eduardo Perozo;D. Marien;Cortes;Luis G. Cuello

  • Molecular determinants of gating at the potassium-channel selectivity filter.

    Julio F Cordero-Morales;Julio F Cordero-Morales;Luis G Cuello;Luis G Cuello;Yanxiang Zhao;Vishwanath Jogini;Vishwanath Jogini

  • Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy.

    Eduardo Perozo;D. Marien Cortes;Luis G. Cuello

  • Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels.

    Eduardo Perozo;Roderick MacKinnon;Francisco Bezanilla;Enrico Stefani

  • Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.

    Rikki N. Hvorup;Birke A. Goetz;Martina Niederer;Kaspar Hollenstein

  • Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

    F. Bezanilla;E. Perozo;E. Stefani

  • Structural basis for the coupling between activation and inactivation gates in K + channels

    Luis G. Cuello;Vishwanath Jogini;Vishwanath Jogini;D. Marien Cortes;D. Marien Cortes;Albert C. Pan;Albert C. Pan

  • pH-dependent gating in the Streptomyces lividans K+ channel.

    Cuello Lg;Romero Jg;Cortes Dm;Perozo E

  • Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.

    D.M Cortes;L.G Cuello;E. Perozo

  • Crystal structure of full-length KcsA in its closed conformation

    Serdar Uysal;Valeria Vásquez;Valentina Tereshko;Kaori Esaki

  • Molecular basis of gating charge immobilization in Shaker potassium channels

    Francisco Bezanilla;Eduardo Perozo;Diane M. Papazian;Enrico Stefani

  • Molecular Architecture of the KvAP Voltage-Dependent K+ Channel in a Lipid Bilayer

    Luis G. Cuello;D. Marien Cortes;Eduardo Perozo

  • Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain

    Qufei Li;Sherry Wanderling;Marcin Paduch;David Medovoy

  • Structure of the KcsA channel intracellular gate in the open state.

    Yi-Shiuan Liu;Pornthep Sompornpisut;Eduardo Perozo

  • Molecular driving forces determining potassium channel slow inactivation.

    Julio F Cordero-Morales;Vishwanath Jogini;Anthony Lewis;Valeria Vásquez;Valeria Vásquez

  • Gating of Shaker K+ channels: I. Ionic and gating currents

    E. Stefani;L. Toro;E. Perozo;F. Bezanilla

  • Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy.

    Huong T. Kratochvil;Joshua K. Carr;Kimberly Matulef;Alvin W. Annen

  • An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.

    Ernesto Vargas;Vladimir Yarov-Yarovoy;Fatemeh Khalili-Araghi;William A. Catterall

Frequent Co-Authors

Benoît Roux
Benoît Roux University of Chicago
Francisco Bezanilla
Francisco Bezanilla University of Chicago
Boris Martinac
Boris Martinac Victor Chang Cardiac Research Institute
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Klaus Schulten
Klaus Schulten University of Illinois at Urbana-Champaign
Shohei Koide
Shohei Koide New York University
Sriram Subramaniam
Sriram Subramaniam University of British Columbia
Enrico Stefani
Enrico Stefani University of California, Los Angeles
Luis S. Mayorga
Luis S. Mayorga National University of Cuyo
Tobin R. Sosnick
Tobin R. Sosnick University of Chicago

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