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Chemistry

D-Index
53
Citations
9990
World Ranking
13088
National Ranking
737

Overview

Ian Collins is affiliated with PharmEnable Therapeutics in the United Kingdom, contributing significantly to research in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans multiple subfields including Molecular Biology, Oncology, Computational Theory and Mathematics, Cancer Research, and Electrical and Electronic Engineering.

Their research focuses on key topics such as Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Computational Drug Discovery Methods, Cancer-related Molecular Pathways, Heat shock proteins research, Protein Structure and Dynamics, and NF-κB Signaling Pathways.

Several research papers authored or co-authored by Ian Collins have been published in well-known scientific journals. These papers include:

  • Target 2035 - update on the quest for a probe for every protein, 2021, RSC Medicinal Chemistry
  • CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells, 2020, Cancer Research
  • The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use, 2022, Nucleic Acids Research
  • Evolution of kinase polypharmacology across HSP90 drug discovery, 2021, Cell chemical biology
  • SimPLIT: Simplified Sample Preparation for Large-Scale Isobaric Tagging Proteomics, 2022, Journal of Proteome Research

Frequent collaborators in their research include John Caldwell, Rob L. M. van Montfort, Rosemary Burke, Craig McAndrew, and Mark Stubbs, reflecting ongoing partnerships across several projects.

Their scholarly output is also represented in numerous publication venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • RSC Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • iScience
  • ChemBioChem

Best Publications

  • Macrocycles in new drug discovery

    Jamie Mallinson;Ian Collins

  • 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

    Paul A. Brough;Wynne Aherne;Xavier Barril;Jenifer Borgognoni

  • Normal Human Tissues, in Addition to Some Tumors, Express Multiple Different CD44 Isoforms

    Stephen B. Fox;Jonathan Fawcett;David G. Jackson;Ian Collins

  • Photoaffinity labeling in target- and binding-site identification

    Ewan Smith;Ian Collins

  • Probing the Probes: Fitness Factors For Small Molecule Tools

    Paul Workman;Ian Collins

  • Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

    Maruf M. U. Ali;Maruf M. U. Ali;Tina Bagratuni;Emma L. Davenport;Piotr R Nowak

  • Measuring and interpreting the selectivity of protein kinase inhibitors

    Lynette A. Smyth;Ian Collins

  • Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles

    M. B. Van Niel;I. Collins;M. S. Beer;H. B. Broughton

  • Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway.

    Ian Collins;Hannah Wang;John J. Caldwell;Raj Chopra

  • Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors

    John R Atack;Peter H Hutson;Neil Collinson;George Marshall

  • Saturated and unsaturated lactones

    Ian Collins

  • 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels

    Ian Collins;Christopher Moyes;William B Davey;Michael Rowley

  • Ortho-condensed pyridine and pyrimidine derivatives (e.g., purines) as protein kinases inhibitors

    Valerio Berdini;Robert George Boyle;Gordon Saxty;David Winter Walker

  • 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

    Rowley M;Broughton Hb;Collins I;Baker R

  • Gamma-secretase inhibitors

    Ian James Collins;Joanne Clare Hannam;Andrew Madin;Mark Peter Ridgill

  • Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

    David J Haydon;JamesM. Bennett;David A. Brown;Ian Collins

  • Arylethanolamines derived from salicylamide with alpha- and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides.

    James E. Clifton;Ian Collins;Peter Hallett;David Hartley

  • Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.

    J.J. Caldwell;T.G. Davies;A. Donald;T. Mchardy

  • A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera

    Thomas G. Davies;Marcel L. Verdonk;Brent Graham;Susanne Saalau-Bethell

  • Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

    Lloyd G. Czaplewski;Ian Collins;E. Andrew Boyd;David Brown

  • Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

    Daniel K. Whelligan;Savade Solanki;Dawn Taylor;Douglas W. Thomson

  • Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

    Tatiana McHardy;John J. Caldwell;Kwai-Ming Cheung;Lisa J. Hunter

Frequent Co-Authors

Paul Workman
Paul Workman Institute of Cancer Research
Andrew B. Holmes
Andrew B. Holmes University of Melbourne
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)
Florence I. Raynaud
Florence I. Raynaud Institute of Cancer Research
Suzanne A. Eccles
Suzanne A. Eccles Institute of Cancer Research
Paul D. Leeson
Paul D. Leeson Loughborough University
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Raymond Baker
Raymond Baker MSD (United States)
Edward A. Anderson
Edward A. Anderson University of Oxford
David Barford
David Barford MRC Laboratory of Molecular Biology

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