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Paul D. Leeson

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 56 11437 10307 647 575 161 17612

Paul D. Leeson publications per year

The chart shows the history of publications by Paul D. Leeson between 1976 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Paul D. Leeson published across 50 years, from 1976 to 2025, averaging 3.8 papers a year. Output peaked at 29 publications in 1994. 9 of the 192 publications appeared in the last two years.

No. of publications
5 10 15 20 25
Bar chart. Horizontal axis: year, 1976 to 2025. Vertical axis: number of publications, 0 to 29. Peak 29 publications in 1994. 1976: 1 publication 1977: 0 publications 1978: 0 publications 1979: 0 publications 1980: 0 publications 1981: 0 publications 1982: 0 publications 1983: 0 publications 1984: 3 publications 1985: 0 publications 1986: 1 publication 1987: 0 publications 1988: 10 publications 1989: 10 publications 1990: 12 publications 1991: 7 publications 1992: 18 publications 1993: 17 publications 1994: 29 publications 1995: 7 publications 1996: 12 publications 1997: 13 publications 1998: 6 publications 1999: 7 publications 2000: 0 publications 2001: 1 publication 2002: 0 publications 2003: 1 publication 2004: 3 publications 2005: 0 publications 2006: 0 publications 2007: 2 publications 2008: 0 publications 2009: 0 publications 2010: 2 publications 2011: 5 publications 2012: 1 publication 2013: 1 publication 2014: 3 publications 2015: 3 publications 2016: 2 publications 2017: 0 publications 2018: 2 publications 2019: 0 publications 2020: 1 publication 2021: 1 publication 2022: 1 publication 2023: 1 publication 2024: 5 publications 2025: 4 publications
1976 2025

192 publications in total across all disciplines

View publications per year as a table
Paul D. Leeson: publications per year, 1976 to 2025
Year Publications
1976 1
1977 0
1978 0
1979 0
1980 0
1981 0
1982 0
1983 0
1984 3
1985 0
1986 1
1987 0
1988 10
1989 10
1990 12
1991 7
1992 18
1993 17
1994 29
1995 7
1996 12
1997 13
1998 6
1999 7
2000 0
2001 1
2002 0
2003 1
2004 3
2005 0
2006 0
2007 2
2008 0
2009 0
2010 2
2011 5
2012 1
2013 1
2014 3
2015 3
2016 2
2017 0
2018 2
2019 0
2020 1
2021 1
2022 1
2023 1
2024 5
2025 4
Total 192
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Paul D. Leeson publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Paul D. Leeson sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 161–180 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 161 publications — 18th percentile

18% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623
121–140 918
141–160 1,218
161–180 1,350 161
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270
461–480 265
481–500 252
501–520 201
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Paul D. Leeson D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Paul D. Leeson sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 56–57 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 56 D-Index — 36th percentile

36% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289
42–43 612
44–45 808
46–47 776
48–49 835
50–51 861
52–53 872
54–55 933
56–57 1,051 56
58–59 930
60–61 882
62–63 834
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
Download as CSV

Overview

Paul D. Leeson is affiliated with Loughborough University in the United Kingdom and has contributed to several research topics within the field of Medicine. Their work primarily intersects with Computational Drug Discovery Methods and Microbial Natural Products and Biosynthesis, with additional focus on Pharmacogenetics and Drug Metabolism, Receptor Mechanisms and Signaling, Click Chemistry and Applications, Chemical Synthesis and Analysis, and Biochemical and Structural Characterization.

The scientist's frequent coauthors include Andrew R. Leach, Robert J. Young, Herbert Waldmann, Anna Lina Heinzke, and Axel Pahl. Their research has been published mainly in the Journal of Medicinal Chemistry, with other contributions appearing in JACS Au and Scientific Data, among additional venues such as the European Journal of Preventive Cardiology and Open Heart.

Leeson's recent papers comprise:

  • Target-Based Evaluation of "Drug-Like" Properties and Ligand Efficiencies, 2021, Journal of Medicinal Chemistry
  • The Time and Place for Nature in Drug Discovery, 2022, JACS Au
  • Occurrence of "Natural Selection" in Successful Small Molecule Drug Discovery, 2024, Journal of Medicinal Chemistry
  • Pseudonatural Products for Chemical Biology and Drug Discovery, 2025, Journal of Medicinal Chemistry
  • A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds, 2024, Scientific Data

Leeson's scholarly output is anchored in several subfields including Computational Theory and Mathematics, Pharmacology, Molecular Biology, Cardiology and Cardiovascular Medicine, and Organic Chemistry. The integration of computational approaches with chemical and biological techniques characterizes the scope of their research efforts.

Best Publications

  • The influence of drug-like concepts on decision-making in medicinal chemistry

    Paul D. Leeson;Brian Springthorpe

  • An analysis of the attrition of drug candidates from four major pharmaceutical companies

    Michael J. Waring;John Arrowsmith;Andrew R. Leach;Paul D. Leeson

  • The role of ligand efficiency metrics in drug discovery

    Andrew L. Hopkins;György M. Keserü;Paul D. Leeson;David C. Rees

  • The Design of Leadlike Combinatorial Libraries.

    Simon J. Teague;Andrew M. Davis;Paul D. Leeson;Tudor Oprea

  • Is There a Difference between Leads and Drugs? A Historical Perspective

    Tudor I. Oprea;Andrew M. Davis;Simon J. Teague;Paul D. Leeson

  • 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

    J A Kemp;A C Foster;P D Leeson;T Priestley

  • A comparison of physiochemical property profiles of development and marketed oral drugs.

    Mark C. Wenlock;Rupert P. Austin;Patrick Barton;and Andrew M. Davis

  • The glycine site of the NMDA receptor — five years on

    John A. Kemp;Paul D. Leeson

  • The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.

    Paul D. Leeson;Leslie L. Iversen

  • Time-related differences in the physical property profiles of oral drugs.

    Paul D Leeson;Andrew M Davis

  • Drug discovery: Chemical beauty contest

    Paul Leeson

  • 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

    J J Kulagowski;H B Broughton;N R Curtis;I M Mawer

  • From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

    Brian Springthorpe;Andrew Bailey;Patrick Barton;Timothy N. Birkinshaw

  • 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

    P D Leeson;R W Carling;K W Moore;A M Moseley

  • Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

    Paul D. Leeson;Raymond Baker;Robert W. Carling;Neil R. Curtis

  • [ 3 H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABA A Receptors which Contain the α5 Subunit

    K. Quirk;P. Blurton;S. Fletcher;P. Leeson

  • The influence of the 'organizational factor' on compound quality in drug discovery

    Paul D. Leeson;Stephen A. St-Gallay

  • Biological Profile of L-745,870, a Selective Antagonist with High Affinity for the Dopamine D4 Receptor

    S. Patel;S. Freedman;K. L. Chapman;F. Emms

  • Molecular inflation, attrition and the rule of five.

    Unknown

  • Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative

    L Singh;A E Donald;A C Foster;P H Hutson

  • 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

    Robert W Carling;Kevin W Moore;Leslie J Street;Deborah Wild

Frequent Co-Authors

Raymond Baker
Raymond Baker MSD (United States)
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)
Ian Collins
Ian Collins PharmEnable Therapeutics
Andrew M. Davis
Andrew M. Davis University of Chicago
Ruth M. McKernan
Ruth M. McKernan MSD (United States)
Richard G. Ball
Richard G. Ball MSD (United States)
Robert M. Owen
Robert M. Owen University of Michigan–Ann Arbor
Miles Congreve
Miles Congreve University of Hertfordshire
Jonathan B. Baell
Jonathan B. Baell Monash University
Richard Hargreaves
Richard Hargreaves Harvard Medical School

External Links

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Bruno O. Villoutreix

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Sean Ekins

University of Arizona

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Publications: 18

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Publications: 16

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