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Biology and Biochemistry

D-Index
55
Citations
9174
World Ranking
15224
National Ranking
1197

Overview

Richard Bayliss is affiliated with the University of Leeds in the United Kingdom. Their research focuses primarily on the intersection of biochemistry, genetics, molecular biology, and medicine, with a substantial number of publications across these fields. The scientist's work spans several subfields including molecular biology, cell biology, oncology, pulmonary and respiratory medicine, and neurology.

Key topics addressed in their research include:

  • Microtubule and mitosis dynamics
  • Lung cancer research studies
  • Lung cancer treatments and mutations
  • Photosynthetic processes and mechanisms
  • Cellular transport and secretion
  • Ubiquitin and proteasome pathways
  • Melanoma and MAPK pathways

Prominent recurring publication venues for Richard Bayliss are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cell Science
  • Biochemical Journal
  • Molecular Oncology
  • Cancer Research

Frequent co-authors include Mark W. Richards, Josephina Sampson, Matthew Batchelor, Jene Choi, and Andrew M. Fry. The number of collaborations with these researchers ranges from 8 to 16 joint publications, indicating ongoing research partnerships.

Selected recent papers by Richard Bayliss are as follows:

  • "Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors," 2022, Journal of Biological Chemistry
  • "Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma," 2021, Nature Cancer
  • "Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma," 2020, Journal of Clinical Investigation
  • "EML4-ALK biology and drug resistance in non-small cell lung cancer: a new phase of discoveries," 2023, Molecular Oncology
  • "Drugging the 'Undruggable' MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers," 2021, Cancer Research

Best Publications

  • Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.

    Richard Bayliss;Teresa Sardon;Isabelle Vernos;Elena Conti

  • Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

    Richard Bayliss;Trevor Littlewood;Murray Stewart

  • Cell cycle regulation by the NEK family of protein kinases

    Andrew M. Fry;Laura O'Regan;Sarah R. Sabir;Richard Bayliss

  • Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta

    Richard Bayliss;Trevor Littlewood;Lisa A. Strawn;Susan R. Wente

  • Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP.

    Richard Bayliss;Katharina Ribbeck;Debra Akin;Helen M Kent

  • Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

    Daniel T Rogerson;Amit Sachdeva;Kaihang Wang;Tamanna Haq

  • Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats.

    Richard Bayliss;Sara W. Leung;Rosanna P. Baker;B.Booth Quimby;B.Booth Quimby

  • Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer.

    C.G. Woo;S. Seo;S.W. Kim;S.J. Jang

  • Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.

    Daniel Bojar;Jacobo Martinez;Julia Santiago;Vladimir Rybin

  • EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients

    Sarah R. Sabir;Sharon Yeoh;George Jackson;Richard Bayliss

  • Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

    Pavithra L. Chavali;Lovorka Stojic;Luke W. Meredith;Nimesh Joseph

  • Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

    Mark W. Richards;Selena G. Burgess;Evon Poon;Anne Carstensen

  • Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import

    Murray Stewart;Rosanna P Baker;Richard Bayliss;Lesley Clayton

  • Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori

    Laurent Terradot;Richard Bayliss;Clasien Oomen;Gordon A. Leonard

  • Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.

    Mark W. Richards;Edward W. P. Law;La’Verne P. Rennalls;Sara Busacca

  • Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic

    Charlotte A. Dodson;Richard Bayliss

  • The primary cilium: guardian of organ development and homeostasis.

    Andrew M Fry;Michelle J Leaper;Richard Bayliss

  • Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

    Richard Bayliss;Richard Bayliss;Jene Choi;Dean A. Fennell;Andrew M. Fry

  • Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.

    Vassilios Bavetsias;Jonathan M. Large;Chongbo Sun;Nathalie Bouloc

  • Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

    Charlotte A Dodson;Magda Kosmopoulou;Mark W Richards;Butrus Atrash

Frequent Co-Authors

Andrew M. Fry
Andrew M. Fry University of Leicester
Gabriel Waksman
Gabriel Waksman University College London
Murray Stewart
Murray Stewart MRC Laboratory of Molecular Biology
Isabelle Vernos
Isabelle Vernos Institució Catalana de Recerca i Estudis Avançats
Martin Eilers
Martin Eilers University of Würzburg
Paul Workman
Paul Workman Institute of Cancer Research
Florence I. Raynaud
Florence I. Raynaud Institute of Cancer Research
Anita H. Corbett
Anita H. Corbett Emory University
Jason W. Chin
Jason W. Chin MRC Laboratory of Molecular Biology
Suzanne A. Eccles
Suzanne A. Eccles Institute of Cancer Research

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