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Biology and Biochemistry

D-Index
62
Citations
13062
World Ranking
10850
National Ranking
833

Overview

Andrew M. Fry is affiliated with the University of Leicester in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with significant contributions to Molecular Biology, Pulmonary and Respiratory Medicine, Cell Biology, Oncology, and Biotechnology.

The scientist's work covers several key topics, including:

  • Microtubule and mitosis dynamics
  • Lung Cancer Treatments and Mutations
  • Lung Cancer Research Studies
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer
  • Occupational and environmental lung diseases
  • Cancer Research and Treatments

Among notable recent publications are:

  • The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure (2020), published in Nature Communications
  • Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface (2020), published in Proceedings of the National Academy of Sciences
  • Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation (2021), published in EMBO Reports
  • EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7 (2020), published in Journal of Cell Science
  • BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma (2020), published in Molecular Cancer Therapeutics

The scientist frequently publishes in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Journal of Biological Chemistry
  • Nature Communications

Frequent collaborators include Laura O'Regan, Richard Bayliss, Sarah L. Pashley, Jene Choi, and Kellie Lucken, with collaboration counts ranging from five to nine publications each.

Best Publications

  • Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

    Patrick Meraldi;Jiri Lukas;Andréw Mark Fry;Andréw Mark Fry;Jiri Bartek

  • Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

    Roy M. Golsteyn;Kirsten E. Mundt;Andrew M. Fry;Erich A. Nigg

  • SUN1 interacts with nuclear lamin a and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

    Farhana Haque;David J. Lloyd;Dawn T. Smallwood;Carolyn L. Dent

  • C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.

    Andrew M. Fry;Thibault Mayor;Patrick Meraldi;York-Dieter Stierhof

  • A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

    Andrew M. Fry;Patrick Meraldi;Erich A. Nigg

  • Cell cycle regulation by the NEK family of protein kinases

    Andrew M. Fry;Laura O'Regan;Sarah R. Sabir;Richard Bayliss

  • Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

    Alison J. Faragher;Andrew M. Fry

  • The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

    Thibault Mayor;York-Dieter Stierhof;Kayoko Tanaka;Andrew M. Fry

  • The Nek2 protein kinase: a novel regulator of centrosome structure

    Andrew M Fry

  • IN VITRO ASSEMBLY OF A FUNCTIONAL HUMAN CDK7-CYCLIN H COMPLEX REQUIRES MAT1, A NOVEL 36 KDA RING FINGER PROTEIN

    J. P. Tassan;M. Jaquenoud;A. M. Fry;S. Frutiger

  • Mitotic regulation by NIMA-related kinases.

    Laura O'Regan;Joelle Blot;Andrew M Fry

  • APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

    Rebecca S. Hames;Rebecca S. Hames;Samantha L. Wattam;Samantha L. Wattam;Hiroyuki Yamano;Rachid Bacchieri;Rachid Bacchieri

  • Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

    Daniel T Rogerson;Amit Sachdeva;Kaihang Wang;Tamanna Haq

  • The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.

    Daniel G. Hayward;Robert B. Clarke;Alison J. Faragher;Meenu R. Pillai

  • Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity

    Andreas Schmidt;Peter I. Duncan;Nadine R. Rauh;Guido Sauer

  • The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

    Laura O'Regan;Andrew M. Fry

  • Relationship between Topoisomerase II Level and Chemosensitivity in Human Tumor Cell Lines

    A. M. Fry;C. M. Chresta;S. M. Davies;M. C. Walker

  • OFD1 Is a Centrosomal/Basal Body Protein Expressed during Mesenchymal-Epithelial Transition in Human Nephrogenesis

    Leila Romio;Andrew M. Fry;Paul J.D. Winyard;Sue Malcolm

  • Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

    Balca R. Mardin;Cornelia Lange;Joanne E. Baxter;Tara Hardy

  • Early mitotic degradation of Nek2A depends on Cdc20- independent interaction with the APC/C

    Michelle J. Hayes;Yuu Kimata;Samantha L. Wattam;Catherine Lindon

Frequent Co-Authors

Richard Bayliss
Richard Bayliss University of Leeds
Erich A. Nigg
Erich A. Nigg University of Basel
Ian D. Hickson
Ian D. Hickson University of Copenhagen
Bernard T. Golding
Bernard T. Golding Newcastle University
Jason W. Chin
Jason W. Chin MRC Laboratory of Molecular Biology
York-Dieter Stierhof
York-Dieter Stierhof University of Tübingen
Uwe Wolfrum
Uwe Wolfrum Johannes Gutenberg University of Mainz
Enza Maria Valente
Enza Maria Valente University of Pavia
Alan F. Wright
Alan F. Wright University of Edinburgh
Arnold Munnich
Arnold Munnich Necker-Enfants Malades Hospital

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