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Chemistry

D-Index
66
Citations
15442
World Ranking
7283
National Ranking
419

Overview

Bernard T. Golding is affiliated with Newcastle University in the United Kingdom. Their research output spans multiple disciplines within chemistry and molecular biology, emphasizing crystallography and synthetic organic chemistry. The academic work involves a range of topics primarily focused on crystallization and solubility studies, as well as X-ray diffraction in crystallography.

The main fields of study covered by their publications are:

  • Chemistry
  • Materials Science
  • Biochemistry, Genetics and Molecular Biology

Subfields of study in their research portfolio include:

  • Materials Chemistry
  • Organic Chemistry
  • Molecular Biology
  • Cancer Research
  • Physical and Theoretical Chemistry

The main topics addressed in their publications are:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Click Chemistry and Applications
  • Chemical Synthesis and Analysis
  • Synthetic Organic Chemistry Methods
  • Asymmetric Synthesis and Catalysis
  • Crystallography and molecular interactions

Recent published papers by Bernard T. Golding include:

  • Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction, 2021, Journal of Medicinal Chemistry
  • The 5,6,7,8-Tetrahydro-2-Naphthoyl-Coenzyme A Reductase Reaction in the Anaerobic Degradation of Naphthalene and Identification of Downstream Metabolites, 2020, Applied and Environmental Microbiology
  • 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase, 2020, RSC Medicinal Chemistry
  • An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase, 2021, Journal of Medicinal Chemistry
  • Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor, 2022, Journal of Medicinal Chemistry

Frequent coauthors contributing to their body of work include:

  • Bian Zhang
  • Paul G. Waddell
  • Masuma Begum
  • Céline Cano
  • M.E.M. Noble

Bernard T. Golding often publishes in several established venues, notably:

  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry
  • Chemico-Biological Interactions
  • Applied and Environmental Microbiology
  • RSC Medicinal Chemistry

Best Publications

  • Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment

    Ralf Rabus;Matthias Boll;Johann Heider;Rainer U. Meckenstock

  • Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

    Justin J.J. Leahy;Bernard T. Golding;Roger J. Griffin;Ian R. Hardcastle

  • Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase

    Alex William White;Robert Almassy;A. Hilary Calvert;Nicola J. Curtin

  • Radical enzymes in anaerobes.

    Wolfgang Buckel;Bernard T. Golding

  • Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

    T.G Davies;J Bentley;C.E Arris;F.T Boyle

  • Metagenomic analysis and metabolite profiling of deep-sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill

    Nikole Elizabeth Kimes;Amy V. Callaghan;Deniz F Aktas;Whitney L Smith

  • Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.

    C.E Arris;F.T Boyle;A.H Calvert;N.J Curtin

  • Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

    Roger J. Griffin;Gabriele Fontana;Bernard T. Golding;Sophie Guiard

  • Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

    Donald J Skalitzky;Joseph T Marakovits;Karen A Maegley;Anne Ekker

  • Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

    Ian R Hardcastle;Xiaoling Cockcroft;Nicola J Curtin;Marine Desage El-Murr

  • Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

    K J Bowman;A White;B T Golding;R J Griffin

  • Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

    R J Griffin;S Srinivasan;K Bowman;A H Calvert

  • Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.

    S Boulton;LC Pemberton;JK Porteous;NJ Curtin

  • Glutamate and 2-methyleneglutarate mutase: from microbial curiosities to paradigms for coenzyme B12-dependent enzymes

    Wolfgang Buckel;Bernard T. Golding

  • Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.

    Marc Hetzel;Matthias Brock;Thorsten Selmer;Antonio J. Pierik

  • Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

    Ian R. Hardcastle;Shafiq U. Ahmed;Helen Atkins;Gillian Farnie

  • On the mechanism of action of adenosylcobalamin.

    Bernard T. Golding;Leo Radom

  • N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

    I.R Hardcastle;C.E Arris;J Bentley;F.T Boyle

  • Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.

    Kelly Coffey;Timothy J. Blackburn;Susan Cook;Bernard T. Golding

  • Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.

    Stacie S. Canan Koch;Lars H. Thoresen;Jayashree G. Tikhe;Karen A. Maegley

  • Cyclin dependent kinase inhibitors

    Francis Thomas Boyle;Alan Hilary Calvert;Nicola Jane Curtin;Jane Anne Endicott

Frequent Co-Authors

Nicola J. Curtin
Nicola J. Curtin Newcastle University
Wolfgang Buckel
Wolfgang Buckel Philipp University of Marburg
William Clegg
William Clegg Newcastle University
Jane A. Endicott
Jane A. Endicott Newcastle University
Martin E.M. Noble
Martin E.M. Noble Newcastle University
Mark R. J. Elsegood
Mark R. J. Elsegood Loughborough University
Leo Radom
Leo Radom University of Sydney
Louise N. Johnson
Louise N. Johnson University of Oxford
Antonio J. Pierik
Antonio J. Pierik Technical University of Kaiserslautern
Ralf Rabus
Ralf Rabus Carl von Ossietzky University of Oldenburg

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