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Biology and Biochemistry

D-Index
68
Citations
13053
World Ranking
7970
National Ranking
587

Overview

Antonio J. Pierik is affiliated with the Technical University of Kaiserslautern in Germany and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, as well as energy research. Their work spans molecular biology, renewable energy and sustainability, materials chemistry, inorganic chemistry, and nutrition and dietetics.

The main research topics addressed by Antonio J. Pierik include:

  • Metalloenzymes and iron-sulfur proteins
  • Metal-Catalyzed Oxygenation Mechanisms
  • Photosynthetic Processes and Mechanisms
  • Trace Elements in Health
  • RNA modifications and cancer
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

The recent papers authored or co-authored by Pierik demonstrate ongoing engagement with multiple aspects of biochemical and structural studies:

  • "Structures of the sulfite detoxifying F420-dependent enzyme from Methanococcales," 2023, published in Nature Chemical Biology
  • "Turn-on fluorescence sensors based on dynamic intramolecular N→B-coordination," 2020, published in Organic Chemistry Frontiers
  • "A noncanonical cytochrome c stimulates calcium binding by PilY1 for type IVa pili formation," 2022, published in Proceedings of the National Academy of Sciences
  • "Cytosolic iron-sulfur protein assembly system identifies clients by a C-terminal tripeptide," 2023, published in Proceedings of the National Academy of Sciences
  • "Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol," 2024, published in Proceedings of the National Academy of Sciences

Antonio J. Pierik frequently publishes in venues that focus on high-impact and preprint research dissemination. Notable frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • The Cambridge Structural Database
  • Communications Biology
  • Zenodo (CERN European Organization for Nuclear Research)

Collaborative research is a significant aspect of Pierik's work. Frequent co-authors include:

  • Raphael Koch
  • Andreas Orthaber
  • Frank Pammer
  • Volker Schünemann
  • Catharina M. Blinn

Antonio J. Pierik's research covers diverse biochemical mechanisms and structural biology approaches, with a strong emphasis on metalloenzymes and iron-sulfur proteins. Their work contributes to understanding both fundamental biological systems and applications related to energy and materials chemistry.

Best Publications

  • Biological activation of hydrogen.

    Randolph P. Happe;Winfried Roseboom;Antonio J. Pierik;Simon P. J. Albracht

  • The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism ☆

    Roland Lill;Bastian Hoffmann;Sabine Molik;Antonio J. Pierik

  • Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.

    Alex D. Sheftel;Oliver Stehling;Antonio J. Pierik;Hans-Peter Elsässer

  • Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

    Daili J A Netz;Carrie M Stith;Martin Stümpfig;Gabriele Köpf

  • A low-spin iron with CN and CO as intrinsic ligands forms the core of the active site in [Fe]-hydrogenases.

    Antonio J. Pierik;Marco Hulstein;Wilfred R. Hagen;Simon P. J. Albracht

  • Carbon Monoxide and Cyanide as Intrinsic Ligands to Iron in the Active Site of [NiFe]-Hydrogenases NiFe(CN)2CO, BIOLOGY’S WAY TO ACTIVATE H2

    Antonio J. Pierik;Winfried Roseboom;Randolph P. Happe;Kimberly A. Bagley

  • MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

    Oliver Stehling;Ajay A. Vashisht;Judita Mascarenhas;Zophonias O. Jonsson

  • Anaerobic Initial Reaction of n-Alkanes in a Denitrifying Bacterium: Evidence for (1-Methylpentyl)succinate as Initial Product and for Involvement of an Organic Radical in n-Hexane Metabolism

    Ralf Rabus;Heinz Wilkes;Astrid Behrends;Antje Armstroff

  • Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I

    Alex D. Sheftel;Oliver Stehling;Antonio J. Pierik;Daili J. A. Netz

  • Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.

    Jan Bursy;Anne U. Kuhlmann;Marco Pittelkow;Holger Hartmann

  • Crystal Structures of Nucleotide-Free and Glutathione-Bound Mitochondrial ABC Transporter Atm1

    Vasundara Srinivasan;Antonio J. Pierik;Roland Lill;Roland Lill

  • The hydrogenase‐like Nar1p is essential for maturation of cytosolic and nuclear iron–sulphur proteins

    Janneke Balk;Antonio J Pierik;Daili J Aguilar Netz;Ulrich Mühlenhoff

  • Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.

    Daili J A Netz;Martin Stümpfig;Carole Doré;Ulrich Mühlenhoff

  • The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

    Roland Lill;Rafal Dutkiewicz;Rafal Dutkiewicz;Sven A. Freibert;Torsten Heidenreich

  • Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes.

    Roland Lill;Rafal Dutkiewicz;Hans-Peter Elsässer;Anja Hausmann

  • The Cfd1–Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol

    Daili J A Netz;Antonio J Pierik;Martin Stümpfig;Ulrich Mühlenhoff

  • The iron–sulphur protein Ind1 is required for effective complex I assembly

    Katrine Bych;Stefan Kerscher;Daili J A Netz;Antonio J Pierik

  • Maturation of cytosolic and nuclear iron-sulfur proteins

    Daili J.A. Netz;Judita Mascarenhas;Oliver Stehling;Antonio J. Pierik

  • The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery.

    Anja Hausmann;Daili J. Aguilar Netz;Janneke Balk;Antonio J. Pierik

  • Osmotically Induced Synthesis of the Compatible Solute Hydroxyectoine Is Mediated by an Evolutionarily Conserved Ectoine Hydroxylase

    Jan Bursy;Antonio J. Pierik;Nathalie Pica;Erhard Bremer

Frequent Co-Authors

Roland Lill
Roland Lill Philipp University of Marburg
Wilfred R. Hagen
Wilfred R. Hagen Delft University of Technology
Wolfgang Buckel
Wolfgang Buckel Philipp University of Marburg
Ulrich Mühlenhoff
Ulrich Mühlenhoff Philipp University of Marburg
Eckhard Bill
Eckhard Bill Max Planck Society
Bernard T. Golding
Bernard T. Golding Newcastle University
Janneke Balk
Janneke Balk John Innes Centre
Cees Veeger
Cees Veeger Wageningen University & Research
Mike S. M. Jetten
Mike S. M. Jetten Radboud University
Julius Lukeš
Julius Lukeš Czech Academy of Sciences

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