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Biology and Biochemistry

D-Index
62
Citations
13756
World Ranking
10796
National Ranking
777

Overview

Ulrich Mühlenhoff is affiliated with Philipp University of Marburg in Germany. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions in energy-related studies. The subfields of their work include renewable energy, sustainability and the environment, molecular biology, inorganic chemistry, nutrition and dietetics, and materials chemistry.

The scientist's research encompasses several key topics, including:

  • Metalloenzymes and iron-sulfur proteins
  • Metal-Catalyzed Oxygenation Mechanisms
  • Trace Elements in Health
  • Fungal and yeast genetics research
  • Enzyme Structure and Function
  • RNA modifications and cancer
  • Redox biology and oxidative stress

Ulrich Mühlenhoff has published across several scientific venues, with multiple papers featured in the following journals:

  • FEBS Letters
  • Proceedings of the National Academy of Sciences
  • Nature Chemical Biology
  • Nature Communications
  • Biological Chemistry

Several recent publications illustrate the scope and direction of their research:

  • Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2, 2022, Nature Chemical Biology
  • Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S] cluster fusion on ISCA1-ISCA2 by electron flow from ferredoxin FDX2, 2020, Proceedings of the National Academy of Sciences
  • Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism, 2020, Biological Chemistry
  • N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization, 2021, Nature Communications
  • Glutaredoxins with iron-sulphur clusters in eukaryotes - Structure, function and impact on disease, 2020, Biochimica et Biophysica Acta (BBA) - Bioenergetics

The collaborative nature of their research is indicated by frequent co-authorship with several scientists, including:

  • Roland Lill
  • Oliver Stehling
  • Joseph J. Braymer
  • Vinzent Schulz
  • Sven-A. Freibert

Best Publications

  • Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

    Roland Lill;Ulrich Mühlenhoff

  • The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism ☆

    Roland Lill;Bastian Hoffmann;Sabine Molik;Antonio J. Pierik

  • Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p.

    Ulrich Mühlenhoff;Jana Gerber;Nadine Richhardt;Roland Lill

  • Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms

    Roland Lill;Ulrich Mühlenhoff

  • Iron–sulfur-protein biogenesis in eukaryotes

    Roland Lill;Ulrich Mühlenhoff

  • An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1.

    Jana Gerber;Ulrich Mühlenhoff;Roland Lill

  • Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.

    Alex D. Sheftel;Oliver Stehling;Antonio J. Pierik;Hans-Peter Elsässer

  • An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins.

    Heike Lange;Thomas Lisowsky;Jana Gerber;Ulrich Mühlenhoff

  • The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins

    Ulrich Mühlenhoff;Nadine Richhardt;Michael Ristow;Gyula Kispal

  • Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster

    Ulrich Mühlenhoff;Sabine Molik;José R. Godoy;Marta A. Uzarska

  • Biogenesis of iron-sulfur proteins in eukaryotes: a novel task of mitochondria that is inherited from bacteria.

    Ulrich Mühlenhoff;Roland Lill

  • Role of glutaredoxin-3 and glutaredoxin-4 in the iron-regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae

    Luis Ojeda;Greg Keller;Ulrich Muhlenhoff;Julian C. Rutherford

  • Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis

    Julian C. Rutherford;Luis Ojeda;Janneke Balk;Ulrich Mühlenhoff

  • Essential role of Isd11 in mitochondrial iron–sulfur cluster synthesis on Isu scaffold proteins

    Nils Wiedemann;Eugen Urzica;Bernard Guiard;Hanne Müller

  • A Specific Role of the Yeast Mitochondrial Carriers Mrs3/4p in Mitochondrial Iron Acquisition under Iron-limiting Conditions

    Ulrich Mühlenhoff;Jochen A. Stadler;Nadine Richhardt;Andreas Seubert

  • Iron–sulfur protein maturation in human cells: evidence for a function of frataxin

    Oliver Stehling;Hans-Peter Elsässer;Bernd Brückel;Ulrich Mühlenhoff

  • The hydrogenase‐like Nar1p is essential for maturation of cytosolic and nuclear iron–sulphur proteins

    Janneke Balk;Antonio J Pierik;Daili J Aguilar Netz;Ulrich Mühlenhoff

  • The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation.

    Alex D. Sheftel;Claudia Wilbrecht;Oliver Stehling;Brigitte Niggemeyer

  • Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.

    Daili J A Netz;Martin Stümpfig;Carole Doré;Ulrich Mühlenhoff

  • The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

    Roland Lill;Rafal Dutkiewicz;Rafal Dutkiewicz;Sven A. Freibert;Torsten Heidenreich

Frequent Co-Authors

Roland Lill
Roland Lill Philipp University of Marburg
Antonio J. Pierik
Antonio J. Pierik Technical University of Kaiserslautern
Janneke Balk
Janneke Balk John Innes Centre
Christopher Horst Lillig
Christopher Horst Lillig University of Greifswald
Nicolas Rouhier
Nicolas Rouhier University of Lorraine
Eckhard Bill
Eckhard Bill Max Planck Society
Marc Fontecave
Marc Fontecave Collège de France
Lucia Banci
Lucia Banci University of Florence
Andreas J. Meyer
Andreas J. Meyer University of Bonn
Axel A. Brakhage
Axel A. Brakhage Leibniz Association

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