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Chemistry

D-Index
55
Citations
12232
World Ranking
12028
National Ranking
3227

Research.com Recognitions

  • 2011 - Bioinorganic Chemistry Award, Royal Society of Chemistry (UK)
  • 2009 - Fellow of the American Chemical Society
  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1992 - Fellow of Alfred P. Sloan Foundation

Overview

James A. Cowan is affiliated with The Ohio State University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Renewable Energy, Sustainability and the Environment, Materials Chemistry, Nutrition and Dietetics, and Inorganic Chemistry.

Their scholarly output covers a diverse range of topics including:

  • Metalloenzymes and iron-sulfur proteins
  • Trace Elements in Health
  • DNA and Nucleic Acid Chemistry
  • Chemical Synthesis and Analysis
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Mitochondrial Function and Pathology

Notable recent publications include:

  • Glutathione-coordinated metal complexes as substrates for cellular transporters, 2021, Metallomics
  • Artificial Metalloenzymes: Recent Developments and Innovations in Bioinorganic Catalysis, 2020, Small
  • Copper(ii)l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity, 2020, Dalton Transactions
  • Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria, 2022, Nature Communications
  • Defining the mechanism of the mitochondrial Atm1p [2Fe-2S] cluster exporter, 2020, Metallomics

Frequent co-authors in their body of work include:

  • Zhen Yu
  • Amber L. Hendricks
  • Zechariah Thompson
  • Farukh Arjmand
  • Sabiha Parveen

Publication venues where James A. Cowan has contributed multiple works include:

  • Metallomics
  • Zenodo (CERN European Organization for Nuclear Research)
  • The Cambridge Structural Database
  • Dalton Transactions
  • International Journal of Molecular Sciences

James A. Cowan has received awards and honors including:

  • Bioinorganic Chemistry Award, Royal Society of Chemistry (UK), 2011
  • Fellow of the American Chemical Society, 2009
  • Fellow of the American Association for the Advancement of Science (AAAS), 1997
  • Fellow of Alfred P. Sloan Foundation, 1992

Best Publications

  • Magnesium chemistry and biochemistry

    Michael E Maguire;James A Cowan

  • Metal Activation of Enzymes in Nucleic Acid Biochemistry.

    Cowan Ja

  • Structural and catalytic chemistry of magnesium-dependent enzymes.

    Cowan Ja

  • Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins.

    Taejin Yoon;J A Cowan

  • DNA cleavage by copper-ATCUN complexes. Factors influencing cleavage mechanism and linearization of dsDNA.

    Yan Jin;J. A. Cowan

  • Frataxin-mediated Iron Delivery to Ferrochelatase in the Final Step of Heme Biosynthesis

    Taejin Yoon;J.A. Cowan

  • Catalytic hydrolysis of DNA by metal ions and complexes.

    Alavattam Sreedhara;J. A. Cowan

  • Efficient Inorganic Deoxyribonucleases. Greater than 50-Million-Fold Rate Enhancement in Enzyme-Like DNA Cleavage

    Alavattam Sreedhara;and John D. Freed;J. A. Cowan

  • Control of cytochrome C redox potential: axial ligation and protein environment effects.

    Unknown

  • Competitive Binding in Magnesium Coordination Chemistry: Water versus Ligands of Biological Interest

    Todor Dudev;J. A. Cowan;Carmay Lim

  • A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage.

    Unknown

  • Chemistry of Nitric Oxide with Protein-Bound Iron Sulfur Centers. Insights on Physiological Reactivity

    Matthew W. Foster;J. A. Cowan

  • Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates

    Jeff C. Joyner;Jared Reichfield;J. A. Cowan

  • Photoinduced electron transfer in pyromellitimide-bridged porphyrins

    R.J. Harrison;B. Pearce;G.S. Beddard;J.A. Cowan

  • Influence of stereochemistry and redox potentials on the single- and double-strand DNA cleavage efficiency of Cu(II) and Ni(II) Lys-Gly-His-derived ATCUN metallopeptides.

    Unknown

  • Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: Role of redox chemistry and a conserved aspartate

    Shu-Pao Wu;Gong Wu;Kristene K. Surerus;J. A. Cowan

  • Iron-sulfur cluster biosynthesis: toward an understanding of cellular machinery and molecular mechanism.

    Sheref S. Mansy;J. A. Cowan

  • Metallobiochemistry of RNA. Co(NH3)63+ as a probe for Mg2+(aq) binding sites

    J.A. Cowan

  • Iron-Sulfur Cluster Biosynthesis THERMATOGA MARITIMA IscU IS A STRUCTURED IRON-SULFUR CLUSTER ASSEMBLY PROTEIN

    Sheref S. Mansy;Gong Wu;Kristene K. Surerus;J.A. Cowan

  • Glutathione complexed Fe-S centers.

    Wenbin Qi;Jingwei Li;C. Y. Chain;G. A. Pasquevich

  • Structural and catalytic roles for divalent magnesium in nucleic acid biochemistry

    Alavattam Sreedhara;J.A. Cowan

  • Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe.

    Gong Wu;Sheref S. Mansy;Shu-pao Wu;Kristene K. Surerus

  • A Mutant Human IscU Protein Contains a Stable [2Fe−2S]2+ Center of Possible Functional Significance

    Matthew W. Foster;Sheref S. Mansy;Jungwon Hwang;James E. Penner-Hahn

  • Chemical nucleases.

    Unknown

Frequent Co-Authors

Shu-Pao Wu
Shu-Pao Wu National Yang Ming Chiao Tung University
Ivano Bertini
Ivano Bertini University of Florence
Claudio Luchinat
Claudio Luchinat University of Florence
Michael E. Maguire
Michael E. Maguire Case Western Reserve University
Russ Hille
Russ Hille University of California, Riverside
Farukh Arjmand
Farukh Arjmand Aligarh Muslim University
Yong Xiong
Yong Xiong Yale University
Sheldon G. Shore
Sheldon G. Shore The Ohio State University
Vicki H. Wysocki
Vicki H. Wysocki The Ohio State University
James E. Penner-Hahn
James E. Penner-Hahn University of Michigan–Ann Arbor

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