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Simone Ciofi-Baffoni

Simone Ciofi-Baffoni

D-Index & Metrics

Chemistry

D-Index
47
Citations
7287
World Ranking
15718
National Ranking
573

Overview

Simone Ciofi-Baffoni is affiliated with the University of Florence in Italy. Their research spans multiple areas primarily within biochemistry, genetics, and molecular biology, alongside contributions in energy-related fields.

The scientist's main research interests include the study of metalloenzymes and iron-sulfur proteins, a topic covered extensively across 34 publications. Additional areas of focus involve RNA modifications and cancer, mitochondrial function and pathology, protein degradation and inhibitors, peptidase inhibition and analysis, trace elements in health, and electrocatalysts for energy conversion.

Frequent publication venues for Ciofi-Baffoni include Biomolecules, Journal of the American Chemical Society, Journal of Molecular Biology, Protein Science, and International Journal of Molecular Sciences, each featuring multiple works.

Recent notable publications include:

  • Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2 (2024, ACS Medicinal Chemistry Letters)
  • Iron-sulfur clusters as inhibitors and catalysts of viral replication (2022, Nature Chemistry)
  • Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease (2022, JACS Au)
  • Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins (2022, Biomolecules)
  • GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1 (2020, Journal of the American Chemical Society)

Collaborations have been established with several researchers, including Lucia Banci, Deborah Grifagni, Mario Piccioli, Francesca Camponeschi, and Elena Lenci. Among these coauthors, interactions with Lucia Banci stand out with 11 joint publications.

Overall, Simone Ciofi-Baffoni's scholarly contributions focus heavily on the biochemical mechanisms involving iron-sulfur clusters and their roles in cellular physiology and disease pathology. Their work also extends into the development of molecular inhibitors and degraders targeting pathological proteins, reflecting an interdisciplinary approach connecting molecular biology and medicinal chemistry.

Best Publications

  • Affinity gradients drive copper to cellular destinations

    Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni;Tatiana Kozyreva

  • Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures.

    Fabio Arnesano;Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni

  • MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

    Lucia Banci;Ivano Bertini;Chiara Cefaro;Simone Ciofi-Baffoni

  • Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer.

    Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni;Theodoros Hadjiloi

  • A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding.

    Dionisia P. Sideris;Dionisia P. Sideris;Nikos Petrakis;Nikos Petrakis;Nitsa Katrakili;Despina Mikropoulou;Despina Mikropoulou

  • Cellular copper distribution: a mechanistic systems biology approach

    Lucia Banci;Ivano Bertini;Francesca Cantini;Simone Ciofi-Baffoni

  • Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake

    David Achila;Lucia Banci;Ivano Bertini;Jennifer Bunce

  • Characterization of the Binding Interface between the Copper Chaperone Atx1 and the First Cytosolic Domain of Ccc2 ATPase

    Fabio Arnesano;Lucia Banci;Ivano Bertini;Francesca Cantini

  • Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

    Marta A Uzarska;Veronica Nasta;Benjamin D Weiler;Farah Spantgar

  • A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118).

    Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni;Lydia A. Finney

  • [4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper

    Diego Brancaccio;Angelo Gallo;Mario Piccioli;Ettore Novellino

  • Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly.

    Erica Balatri;Lucia Banci;Ivano Bertini;Francesca Cantini

  • Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the Apo and Cu(I)-loaded States

    Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni;David L. Huffman

  • Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import.

    Lucia Banci;Ivano Bertini;Chiara Cefaro;Lucia Cenacchi

  • Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery

    Diego Brancaccio;Angelo Gallo;Maciej Mikolajczyk;Kairit Zovo

  • Emergence of a Homo sapiens- specific gene family and chromosome 16p11.2 CNV susceptibility

    Xander Nuttle;Giuliana Giannuzzi;Michael H. Duyzend;Joshua G. Schraiber

  • Mechanism of Cu(A) assembly.

    Luciano A Abriata;Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni

  • [2Fe-2S] cluster transfer in iron-sulfur protein biogenesis.

    Lucia Banci;Diego Brancaccio;Simone Ciofi-Baffoni;Rebecca Del Conte

  • Lignin and Mn peroxidase-catalyzed oxidation of phenolic lignin oligomers.

    Lucia Banci;Simone Ciofi-Baffoni;Ming Tien

  • Solution Structure of Cox11, a Novel Type of β-Immunoglobulin-like Fold Involved in CuB Site Formation of Cytochrome c Oxidase

    Lucia Banci;Ivano Bertini;Francesca Cantini;Simone Ciofi-Baffoni

  • Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR.

    Lucia Banci;Ivano Bertini;Vito Calderone;Chiara Cefaro

Frequent Co-Authors

Lucia Banci
Lucia Banci University of Florence
Ivano Bertini
Ivano Bertini University of Florence
Stefano Mangani
Stefano Mangani University of Siena
Xun-Cheng Su
Xun-Cheng Su Nankai University
Nigel J. Robinson
Nigel J. Robinson Durham University
Thomas V. O'Halloran
Thomas V. O'Halloran Northwestern University
Ming Tien
Ming Tien Pennsylvania State University
Francisco J. Ruiz-Dueñas
Francisco J. Ruiz-Dueñas Spanish National Research Council
Christopher M. Johnson
Christopher M. Johnson MRC Laboratory of Molecular Biology
Evan E. Eichler
Evan E. Eichler University of Washington

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