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Neuroscience

D-Index
44
Citations
7357
World Ranking
7185
National Ranking
27

Overview

József Toldi is affiliated with the University of Szeged in Hungary and has contributed extensively to neuroscience research, with a focus on neuropsychiatric and neurodegenerative disorders. Their work primarily explores the biochemical pathways related to tryptophan metabolism in the brain and its implications for mental health and neurological diseases.

Their research spans several interconnected fields, including:

  • Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Social Psychology
  • Psychiatry and Mental Health
  • Neurology

Toldi's investigations address key topics such as:

  • Tryptophan and brain disorders
  • Stress Responses and Cortisol
  • Neuroendocrine regulation and behavior
  • Bipolar Disorder and Treatment
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mental Health Research Topics
  • Multiple Sclerosis Research Studies

Their recent publications feature studies on inflammatory mechanisms in neurodegenerative diseases, neurochemical changes following brain injury, and biomarkers for neurological recovery. Key papers include:

  • Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines, 2020, International Journal of Molecular Sciences
  • Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder, 2025, Frontiers in Bioscience-Landmark
  • Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma, 2021, Heliyon
  • Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy: A pilot study, 2021, Advances in Clinical and Experimental Medicine
  • The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration, 2025, Journal of Neurochemistry

The majority of Toldi's contributions appear in the publication venues Preprints.org, International Journal of Molecular Sciences, Frontiers in Bioscience-Landmark, Journal of Neurochemistry, and Advances in Clinical and Experimental Medicine.

József Toldi frequently collaborates with several researchers, including:

  • László Vécsei
  • Masaru Tanaka
  • Etsuro Ono
  • Keiko Takeda
  • Kinuyo Ozaki

Throughout their career, Toldi has maintained a research focus on elucidating the neurochemical bases of psychiatric and neurological disorders, particularly via the kynurenine pathway and related neuroinflammatory processes. This work supports a broader understanding of how neuroendocrine regulation and stress responses impact brain function in health and disease.

Best Publications

  • Kynurenines in the CNS: recent advances and new questions.

    László Vécsei;Levente Szalárdy;Ferenc Fülöp;József Toldi;József Toldi

  • Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

    Katalin Sas;Hermina Robotka;József Toldi;László Vécsei;László Vécsei

  • Exploring the Etiological Links Behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

    Masaru Tanaka;József Toldi;László Vécsei

  • Role of kynurenines in the central and peripherial nervous systems

    Hajnalka Németh;József Toldi;László Vécsei

  • The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

    Eniko Vamos;Arpad Pardutz;Peter Klivenyi;Jozsef Toldi

  • The Janus-face kynurenic acid

    Éva Rózsa;Hermina Robotka;László Vécsei;József Toldi

  • Activation of the primary motor cortex by somatosensory stimulation in adult rats is mediated mainly by associational connections from the somatosensory cortex.

    Tamás Farkas;Zsolt Kis;József Toldi;Joachim R. Wolff

  • β-Amyloid pathology in the entorhinal cortex of rats induces memory deficits: Implications for Alzheimer’s disease

    E. Sipos;A. Kurunczi;Á. Kasza;J. Horváth

  • Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.

    H. Németh;J. Toldi;L. Vécsei

  • Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease

    Dénes Zádori;Gábor Nyiri;András Szonyi;István Szatmári

  • Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

    Dénes Zádori;Péter Klivényi;Levente Szalárdy;Ferenc Fülöp

  • Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

    Zsuzsanna Bohár;József Toldi;Ferenc Fülöp;László Vécsei

  • The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acid.

    E. Knyihar-Csillik;A. Mihaly;B. Krisztin-Peva;Hermina Robotka

  • Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils

    Gábor Gigler;Gábor Szénási;Annamária Simó;György István Lévay

  • Migraine, Neurogenic Inflammation, Drug Development - Pharmacochemical Aspects.

    Melinda Lukacs;Janos Tajti;Ferenc Fulop;Jozsef Toldi

  • l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus

    Enikő Vámos;Árpád Párdutz;Hedvig Varga;Zsuzsanna Bohár

  • Novel tracing paradigms—genetically engineered herpesviruses as tools for mapping functional circuits within the CNS: present status and future prospects

    Zsolt Boldogköi;Attila Sı́k;Ádám Dénes;Anikó Reichart

  • Kynurenines, neurodegeneration and Alzheimer's disease.

    Zsigmond Tamas Kincses;József Toldi;László Vécsei

  • Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies

    D. Zádori;P. Klivényi;E. Vámos;F. Fülöp

  • Biphasic reorganization of somatotopy in the primary motor cortex follows facial nerve lesions in adult rats

    Jozsef Toldi;Rainer Laskawi;Michael Landgrebe;Joachim R. Wolff

  • Neuronal plasticity induced by neonatal monocular (and binocular) enucleation

    J. Toldi;O. Fehér;J.-R. Wolff

Frequent Co-Authors

László Vécsei
László Vécsei University of Szeged
Joachim R. Wolff
Joachim R. Wolff University of Göttingen
Péter Klivényi
Péter Klivényi University of Szeged
Tamás F. Freund
Tamás F. Freund Institute of Experimental Medicine
Ivan Bodis-Wollner
Ivan Bodis-Wollner SUNY Downstate Medical Center
Miklós Palkovits
Miklós Palkovits Semmelweis University
Ferenc Bari
Ferenc Bari University of Szeged
Gary H. Cohen
Gary H. Cohen University of Pennsylvania
Deepak Shukla
Deepak Shukla University of Illinois at Chicago
Gábor M. Kovács
Gábor M. Kovács Eötvös Loránd University

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