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Biology and Biochemistry

D-Index
69
Citations
22955
World Ranking
7272
National Ranking
559

Overview

Stephen S. Taylor is affiliated with the University of Manchester in the United Kingdom. Their research primarily focuses on areas spanning Biochemistry, Genetics and Molecular Biology, and Medicine, contributing to a total of 42 and 23 publications in these fields respectively.

The scientist has concentrated on several subfields, including Molecular Biology, Oncology, Cancer Research, Reproductive Medicine, and Plant Science. Their work addresses topics such as PARP inhibition in cancer therapy, ovarian cancer diagnosis and treatment, cancer genomics and diagnostics, DNA repair mechanisms, genomics and chromatin dynamics, CRISPR and genetic engineering, and RNA modifications related to cancer.

Recent notable publications by Stephen S. Taylor include:

  • Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes, 2021, Genome Medicine
  • A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity, 2020, Nature Communications
  • Human spermbots for patient-representative 3D ovarian cancer cell treatment, 2020, Nanoscale
  • DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy, 2021, Progress in Biophysics and Molecular Biology
  • TP53 loss initiates chromosomal instability in fallopian tube epithelial cells, 2021, Disease Models & Mechanisms

Stephen S. Taylor frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Annals of Oncology, NAR Cancer, Genome Medicine, and Nature Communications.

Frequent coauthors include:

  • Robert D. Morgan
  • Louisa Nelson
  • Joanne C. McGrail
  • Bethany M. Barnes
  • Anthony Tighe

Best Publications

  • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

    Claire Ditchfield;Victoria L. Johnson;Anthony Tighe;Rebecca Ellston

  • Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

    Karen E. Gascoigne;Stephen S. Taylor

  • The spindle assembly checkpoint.

    Pablo Lara-Gonzalez;Frederick G. Westhorpe;Stephen S. Taylor

  • Aurora-kinase inhibitors as anticancer agents.

    Nicholas Keen;Stephen Taylor

  • Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

    Libor Macůrek;Arne Lindqvist;Dan Lim;Michael A. Lampson

  • Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

    Stephen S Taylor;Frank McKeon

  • RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

    Lígia Tavares;Emilia Dimitrova;David Oxley;Judith Webster

  • The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase

    Stephen S. Taylor;Edward Ha;Frank McKeon

  • Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

    Stefano Santaguida;Anthony Tighe;Anna Morena D'Alise;Stephen S. Taylor

  • Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

    Jim R Hughes;Nigel Roberts;Simon McGowan;Deborah Hay

  • How do anti-mitotic drugs kill cancer cells?

    Karen E. Gascoigne;Stephen S. Taylor

  • ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

    Martin J. Law;Karen M. Lower;Hsiao P.J. Voon;Jim R. Hughes

  • The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment

    Jun Dai;Sammy Sultan;Stephen S. Taylor;Jonathan M.G. Higgins

  • Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

    Victoria L. Johnson;Maria I. F. Scott;Sarah V. Holt;Deema Hussein

  • Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

    Petter S. Woll;Una Kjällquist;Onima Chowdhury;Helen Doolittle

  • Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.

    Laura Hewitt;Anthony Tighe;Stefano Santaguida;Anne M. White

  • Validating Aurora B as an anti-cancer drug target.

    Fiona Girdler;Karen E. Gascoigne;Patrick A. Eyers;Sonya Hartmuth

  • Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

    William A Weiss;Stephen S Taylor;Kevan M Shokat

  • Intragenic Enhancers Act as Alternative Promoters

    Monika S. Kowalczyk;Jim R. Hughes;David Garrick;Magnus D. Lynch

  • Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

    David Clynes;Clare Jelinska;Barbara Xella;Helena Ayyub

Frequent Co-Authors

Simon J. McGowan
Simon J. McGowan University of Oxford
Paresh Vyas
Paresh Vyas University of Oxford
James Hughes
James Hughes Emory University
Douglas R. Higgs
Douglas R. Higgs University of Oxford
Richard J. Gibbons
Richard J. Gibbons University of Oxford
Andrea Musacchio
Andrea Musacchio Max Planck Society
Sarah Rowland-Jones
Sarah Rowland-Jones University of Sheffield
Claus Nerlov
Claus Nerlov University of Oxford
Sten Eirik W. Jacobsen
Sten Eirik W. Jacobsen University of Oxford
Grace John-Stewart
Grace John-Stewart University of Washington

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