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Giannis Spyrou

Giannis Spyrou

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
8481
World Ranking
18685
National Ranking
293

Overview

Giannis Spyrou is affiliated with Linköping University in Sweden and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields including Cardiology and Cardiovascular Medicine, Molecular Biology, Genetics, Immunology, and Biotechnology.

The scientist's research topics notably cover cardiac electrophysiology and arrhythmias, atrial fibrillation management and outcomes, microbial inactivation methods, retinal development and disorders, photoreceptor and optogenetics research, advanced fluorescence microscopy techniques, and cardiovascular effects of exercise.

Giannis Spyrou has authored and coauthored several papers published in multiple academic journals. Significant publications include:

  • AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity (2020, Human Molecular Genetics)
  • Deregulation of the Kallikrein Protease Family in the Salivary Glands of the Sjögren's Syndrome ERdj5 Knockout Mouse Model (2021, Frontiers in Immunology)
  • Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial (2020, Translational Medicine Communications)
  • Sizing Up Extracellular DNA: Instant Chromatin Discharge From Cells When Placed in Serum-Free Conditions (2020, Frontiers in Cell and Developmental Biology)
  • Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial (2020, Research Square)

Frequent coauthors in their research include Gabriella Boano, Meriam Åström Aneq, Helena Enocsson, Emmanouil Charitakis, and Farkas Vánky. These collaborators appear regularly across several publications.

The venues where Giannis Spyrou commonly publishes reflect a variety of biomedical and clinical research fields. These include:

  • Research Square
  • Human Molecular Genetics
  • Translational Medicine Communications
  • Frontiers in Immunology
  • Frontiers in Cell and Developmental Biology

Best Publications

  • Cloning and Expression of a Novel Mammalian Thioredoxin

    Giannis Spyrou;Eva Enmark;Antonio Miranda-Vizuete;Jan-Åke Gustafsson

  • Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis.

    Toru Tanaka;Fumihito Hosoi;Yuko Yamaguchi-Iwai;Hajime Nakamura

  • IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF A NOVEL MITOCHONDRIAL THIOREDOXIN SYSTEM IN SACCHAROMYCES CEREVISIAE

    José R. Pedrajas;Effie Kosmidou;Antonio Miranda-Vizuete;Jan-Åke Gustafsson

  • The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.

    Ling Xia;Tomas Nordman;Jerker M. Olsson;Anastassios Damdimopoulos

  • Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.

    Anastasios E. Damdimopoulos;Antonio Miranda-Vizuete;Markku Pelto-Huikko;Jan Åke Gustafsson

  • The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta.

    Lotta Johansson;Jane S. Thomsen;Anastasios E. Damdimopoulos;Giannis Spyrou

  • Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity

    José Rafael Pedrajas;Antonio Miranda-Vizuete;Negin Javanmardy;Jan-Åke Gustafsson

  • Human mitochondrial thioredoxin reductase. cDNA cloning, expression and genomic organization

    Antonio Miranda‐Vizuete;Anastasios E. Damdimopoulos;José Rafael Pedrajas;Jan‐Åke Gustafsson

  • Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex.

    Elias S.J. Arnér;Hajime Nakamura;Tetsuro Sasada;Junji Yodoi

  • ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.

    Paula M. Cunnea;Antonio Miranda-Vizuete;Gloria Bertoli;Thomas Simmen

  • The mitochondrial thioredoxin system.

    Antonio Miranda-Vizuete;Anastasios E. Damdimopoulos;Giannis Spyrou

  • Characterization of Sptrx, a Novel Member of the Thioredoxin Family Specifically Expressed in Human Spermatozoa

    Antonio Miranda-Vizuete;Johanna Ljung;Anastasios E. Damdimopoulos;Jan Åke Gustafsson

  • Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes.

    F. Thierry;Giannis Spyrou;M. Yaniv;P. Howley

  • Cloning, expression, and characterization of a novel Escherichia coli thioredoxin

    Antonio Miranda-Vizuete;Anastasios E. Damdimopoulos;Jan-Åke Gustafsson;Giannis Spyrou

  • Selenium and the Thioredoxin and Glutaredoxin Systems

    M. Björnstedt;S. Kumar;L. Björkhem;Giannis Spyrou

  • Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

    Dominique Lallemand;Giannis Spyrou;Moshe Yaniv;Curt M Pfarr;Curt M Pfarr

  • Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

    S. Hirai;M. Izawa;S. Osada;Giannis Spyrou

  • Overexpression of c-jun, junB, or junD affects cell growth differently.

    M. Castellazzi;Giannis Spyrou;N. La Vista;J-P Dangy

  • NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity.

    Mats Andersson;Arne Holmgren;Giannis Spyrou

  • Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells.

    V. Doucas;Giannis Spyrou;M. Yaniv

Frequent Co-Authors

Antonio Miranda-Vizuete
Antonio Miranda-Vizuete Spanish National Research Council
Jan-Åke Gustafsson
Jan-Åke Gustafsson University of Houston
Arne Holmgren
Arne Holmgren Karolinska Institute
Markku Pelto-Huikko
Markku Pelto-Huikko Tampere University
Peter Reichard
Peter Reichard University of Padua
Elias S.J. Arnér
Elias S.J. Arnér Karolinska Institute
Richard Oko
Richard Oko Queen's University
Eckardt Treuter
Eckardt Treuter Karolinska Institute
Anders Rosén
Anders Rosén Linköping University
Junji Yodoi
Junji Yodoi Kyoto University

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