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Immunology

D-Index
98
Citations
28242
World Ranking
801
National Ranking
452

Medicine

D-Index
98
Citations
28450
World Ranking
9028
National Ranking
4651

Overview

Alfred Ayala is affiliated with Brown University in the United States and has conducted extensive research primarily in the fields of Medicine and Immunology and Microbiology. Their work spans several subfields, including Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, Epidemiology, and Infectious Diseases.

The main topics covered in Ayala's research include:

  • Immune Response and Inflammation
  • Sepsis Diagnosis and Treatment
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • Respiratory Support and Mechanisms
  • Neonatal Respiratory Health Research
  • COVID-19 Clinical Research Studies

Recent publications by Ayala include:

  • Blockade of endothelial, but not epithelial, cell expression of PD-L1 following severe shock attenuates the development of indirect acute lung injury in mice (2020), published in American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics (2020), published in Frontiers in Immunology
  • Emerging therapeutic targets for sepsis (2021), published in Expert Opinion on Therapeutic Targets
  • SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model (2020), published in Molecular Medicine
  • Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival (2022), published in Frontiers in Immunology

The frequent co-authors collaborating with Ayala are:

  • Chun-Shiang Chung
  • Sean F. Monaghan
  • Alger M. Fredericks
  • William G. Fairbrother
  • Maya Cohen

The main publication venues where Ayala's research appears include:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Shock
  • Journal of Leukocyte Biology
  • Frontiers in Medicine

Ayala's research integrates multiple disciplines to address mechanisms of immune response, inflammation, and treatment approaches particularly focused on sepsis and respiratory conditions. Their publications demonstrate work on immune checkpoints, therapeutic targets, and the modulation of immune cell populations in complex disease models.

Best Publications

  • MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis

    Matthew J Delano;Philip O. Scumpia;Jason S. Weinstein;Dominique Coco

  • Effect of gender and sex hormones on immune responses following shock.

    Martin K. Angele;Martin G. Schwacha;Alfred Ayala;Irshad H. Chaudry;Irshad H. Chaudry

  • PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

    Xin Huang;Fabienne Venet;Yvonne L. Wang;Alain Lepape

  • The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

    Nicholas S. Ward;Brian Casserly;Alfred Ayala

  • Leukocyte apoptosis and its significance in sepsis and shock.

    Doreen E. Wesche;Joanne L. Lomas-Neira;Mario Perl;Chun-Shiang Chung

  • Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males.

    Rene Zellweger;Matthias W. Wichmann;Matthias W. Wichmann;Alfred Ayala;Alfred Ayala;Susan Stein

  • Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock.

    Edwin A. Deitch;Dazhong Xu;Lisa Franko;Alfred Ayala

  • Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion

    Kirstan K. Donnahoo;Xianzhong Meng;Alfred Ayala;Mark P. Cain

  • Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients.

    Fabienne Venet;Chun-Shiang Chung;Hakim Kherouf;Anne Geeraert

  • Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage.

    A. Ayala;Ping Wang;Z. F. Ba;M. M. Perrin

  • The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins.

    Wolfgang Ertel;Mary H. Morrison;Ping Wang;Zheng F. Ba

  • Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators

    Alfred Ayala;Crystal D. Herdon;Donna L. Lehman;Carol A. Ayala

  • Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients

    Caroline Guignant;Alain Lepape;Xin Huang;Hakim Kherouf

  • Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.

    Matthias W. Wichmann;Matthias W. Wichmann;René Zellweger;Catherine M. DeMaso;Alfred Ayala;Alfred Ayala

  • The new normal: immunomodulatory agents against sepsis immune suppression

    Noelle A. Hutchins;Jacqueline Unsinger;Richard S. Hotchkiss;Alfred Ayala

  • Regulatory T cell populations in sepsis and trauma.

    Fabienne Venet;Chun-Shiang Chung;Guillaume Monneret;Xin Huang

  • Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.

    Alfred Ayala;Michelle M Perrin;Daniel R Meldrum;Wolfgang Ertel

  • Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release

    Alfred Ayala;Donna L. Lehman;Crystal D. Herdon;Irshad H. Chaudry

  • Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone.

    Matthias W. Wichmann;René Zellweger;Catherine M. DeMaso;Alfred Ayala

  • Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) : an international expert consensus initiative for improvement of animal modeling in sepsis

    Marcin F. Osuchowski;Alfred Ayala;Soheyl Bahrami;Michael Bauer

  • Testosterone Receptor Blockade After Hemorrhage in Males: Restoration of the Depressed Immune Functions and Improved Survival Following Subsequent Sepsis

    Martin K. Angele;Matthias W. Wichmann;Matthias W. Wichmann;Alfred Ayala;William G. Cioffi

Frequent Co-Authors

Irshad H. Chaudry
Irshad H. Chaudry University of Alabama at Birmingham
Chun-Shiang Chung
Chun-Shiang Chung Brown University
William G. Cioffi
William G. Cioffi Brown University
Ping Wang
Ping Wang Feinstein Institute for Medical Research
Kirby I. Bland
Kirby I. Bland University of Alabama at Birmingham
Fabienne Venet
Fabienne Venet Claude Bernard University Lyon 1
Daniel R. Meldrum
Daniel R. Meldrum University of Florida
Martin G. Schwacha
Martin G. Schwacha The University of Texas Health Science Center at San Antonio
Jonathan S. Reichner
Jonathan S. Reichner Brown University
Lyle L. Moldawer
Lyle L. Moldawer University of Florida

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