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Biology and Biochemistry

D-Index
77
Citations
28725
World Ranking
4696
National Ranking
354

Overview

William H. Colledge is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Their subfields of study include reproductive medicine, molecular biology, social psychology, genetics, and the endocrine and autonomic systems.

Colledge's work revolves around a core set of topics related to reproductive biology and neuroendocrine functions. These include:

  • Hypothalamic control of reproductive hormones
  • Plant reproductive biology
  • Ovarian function and disorders
  • Neuroendocrine regulation and behavior
  • Regulation of appetite and obesity
  • Genetic and clinical aspects of sex determination and chromosomal abnormalities
  • Neuropeptides and animal physiology

The scientist has published extensively in several venues, with frequent publications in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Endocrinology
  • Journal of Neuroendocrinology

Some of the recent papers authored or co-authored by William H. Colledge include:

  • Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations, 2022, Frontiers in Endocrinology
  • Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility, 2022, Proceedings of the National Academy of Sciences
  • Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain., 2021, Apollo (University of Cambridge)
  • GnRH pulse generator frequency is modulated by kisspeptin and GABA -glutamate interactions in the posterodorsal medial amygdala in female mice, 2022, Journal of Neuroendocrinology
  • Kisspeptin signaling in astrocytes modulates the reproductive axis, 2024, Journal of Clinical Investigation

Throughout their career, Colledge has frequently collaborated with several co-authors, including:

  • Erik Hrabovszky
  • Stephen M. Manchishi
  • Szabolcs Takács
  • Balázs Göcz
  • Katalin Skrapits

Best Publications

  • The GPR54 Gene as a Regulator of Puberty

    Stephanie B. Seminara;Sophie Messager;Emmanouella E. Chatzidaki;Rosemary R. Thresher

  • Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

    Sophie Messager;Emmanouella E. Chatzidaki;Dan Ma;Alan G. Hendrick

  • Involvement of Brca2 in DNA repair.

    Ketan J Patel;Veronica P.C.C Yu;Hyunsook Lee;Anne Corcoran

  • THE ONCOGENIC CYSTEINE-RICH LIM DOMAIN PROTEIN RBTN2 IS ESSENTIAL FOR ERYTHROID DEVELOPMENT

    Alan J. Warren;William H. Colledge;Mark B.L. Carlton;Martin J. Evans

  • Eomesodermin is required for mouse trophoblast development and mesoderm formation

    Andreas P. Russ;Andreas P. Russ;Sigrid Wattler;William H. Colledge;Samuel A. J. R. Aparicio;Samuel A. J. R. Aparicio

  • Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene

    Xavier d'Anglemont de Tassigny;Lisa A. Fagg;John P. C. Dixon;Kate Day

  • DISRUPTION OF C-MOS CAUSES PARTHENOGENETIC DEVELOPMENT OF UNFERTILIZED MOUSE EGGS

    W. H. Colledge;M. B. L. Carlton;G. B. Udy;M. J. Evans

  • Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

    Stephen C. Hyde;Deborah R. Gill;Christopher F. Higgins;Ann E. O. Trezise

  • Synthetic chemerin-derived peptides suppress inflammation through ChemR23.

    Jenna L. Cash;Rosie Hart;Andreas Russ;John P.C. Dixon

  • Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

    B. G. Challis;A. P. Coll;G. S. H. Yeo;S. B. Pinnock

  • Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis

    Alison R. Hayman;Sheila J. Jones;Alan Boyde;Diane Foster

  • Stella is a maternal effect gene required for normal early development in mice.

    Bernhard Payer;Mitinori Saitou;Sheila C. Barton;Rosemary Thresher

  • A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca2+-dependent HCO3− secretion

    U. Seidler;I. Blumenstein;A. Kretz;D. Viellard-Baron

  • Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.

    Marie-Hélène Verlhac;Jacek Z. Kubiak;Michèle Weber;Gérard Géraud

  • Production of a severe cystic fibrosis mutation in mice by gene targeting.

    Rosemary Ratcliff;Martin J. Evans;Alan W. Cuthbert;Lesley J. MacVinish

  • A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis

    D R Gill;K W Southern;K A Mofford;T Seddon

  • Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.

    Hyde Sc;Southern Kw;Gileadi U;Fitzjohn Em

  • Generation and characterization of a delta F508 cystic fibrosis mouse model.

    William H. Colledge;Benjamin S. Abella;Kevin W. Southern;Rosemary Ratcliff

  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

    Darren T. Gilmour;Gholson J. Lyon;Mark B.L. Carlton;Joshua R. Sanes

  • Mouse models of cystic fibrosis: Phenotypic analysis and research applications

    Martina Wilke;Ruvalic M. Buijs-Offerman;Jamil Aarbiou;William H. Colledge

Frequent Co-Authors

Martin J. Evans
Martin J. Evans Cardiff University
Samuel Aparicio
Samuel Aparicio University of British Columbia
Allan E. Herbison
Allan E. Herbison University of Cambridge
Christopher F. Higgins
Christopher F. Higgins Hammersmith Hospital
Stafford L. Lightman
Stafford L. Lightman University of Bristol
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge
Charles Coutelle
Charles Coutelle Imperial College London
Duncan M. Geddes
Duncan M. Geddes Imperial College London
Vincent Prevot
Vincent Prevot University of Lille
Bruce A.J. Ponder
Bruce A.J. Ponder University of Cambridge

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