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Biology and Biochemistry

D-Index
49
Citations
11785
World Ranking
17895
National Ranking
7322

Overview

Vivian J. Bardwell is affiliated with the University of Minnesota in the United States and conducts research primarily in the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine.

Their work spans several prominent subfields, including molecular biology, genetics, reproductive medicine, pediatrics, perinatology and child health, and epidemiology. The research topics covered are diverse, with a focus on epigenetics and DNA methylation, genetic and clinical aspects of sex determination and chromosomal abnormalities, sexual differentiation and disorders, sperm and testicular function, prenatal screening and diagnostics, Hedgehog signaling pathway studies, and genomics and chromatin dynamics.

Bardwell has published extensively across several respected venues. The most frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), with four publications, Nucleic Acids Research, Genes & Development, Developmental Biology, and the Journal of Virology. This distribution illustrates an active engagement with both preprint and peer-reviewed journals in molecular and developmental biology.

Recent papers authored or co-authored by Bardwell cover a variety of topics relevant to sexual development and disease mechanisms:

  • The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming (2021, Nucleic Acids Research)
  • Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation (2020, Genes & Development)
  • OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR (2020, Developmental Biology)
  • Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease (2020, Biochemistry)
  • Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration (2022, Science Advances)

Bardwell frequently collaborates with several researchers, including Micah D. Gearhart, Mark W. Murphy, David Zarkower, Hiroaki Okae, and Kellie S. Agrimson. These co-authorships reflect interdisciplinary efforts across developmental biology and genetic research themes.

Best Publications

  • The POZ domain: a conserved protein-protein interaction motif.

    Vivian J. Bardwell;Richard Treisman

  • Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation

    Christopher S. Raymond;Mark W. Murphy;M. Gerard O'Sullivan;Vivian J. Bardwell

  • DMRT1 prevents female reprogramming in the postnatal mammalian testis

    Clinton K. Matson;Mark W. Murphy;Aaron L. Sarver;Michael D. Griswold

  • Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.

    Christopher S. Raymond;Jae R. Kettlewell;Betsy Hirsch;Vivian J. Bardwell

  • BCoR, a novel corepressor involved in BCL-6 repression

    Khanh D. Huynh;Wolfgang Fischle;Eric Verdin;Vivian J. Bardwell

  • ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

    Bart Lutterbach;Jennifer J. Westendorf;Bryan Linggi;Andrea Patten

  • The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT

    Khanh D Huynh;Vivian J Bardwell

  • Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets

    Micah D. Gearhart;Connie M. Corcoran;Joseph A. Wamstad;Vivian J. Bardwell

  • A Region of Human Chromosome 9p Required for Testis Development Contains Two Genes Related to Known Sexual Regulators

    Christopher S. Raymond;Emily D. Parker;Jae R. Kettlewell;Laura G. Brown

  • The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells

    Clinton K. Matson;Clinton K. Matson;Mark W. Murphy;Michael D. Griswold;Shosei Yoshida

  • Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR

    David Ng;Nalin Thakker;Connie M Corcoran;Dian Donnai

  • Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors

    Ari Melnick;Graeme Carlile;K. Farid Ahmad;Chih Li Kiang

  • EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

    Wendy Béguelin;Matt Teater;Micah D. Gearhart;María Teresa Calvo Fernández

  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

    Anthony D. Krentz;Mark W. Murphy;Shinseog Kim;Shinseog Kim;Matthew S. Cook

  • Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

    Alexandru F. Ghetu;Connie M. Corcoran;Leandro Cerchietti;Vivian J. Bardwell

  • Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation.

    Shinseog Kim;Vivian J Bardwell;David A Zarkower

  • Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.

    Shinseog Kim;Jae R Kettlewell;Robert C Anderson;Vivian J Bardwell

  • A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

    Katerina Hatzi;Yanwen Jiang;Chuanxin Huang;Francine Garrett-Bakelman

  • Evolutionary dynamics of the DM domain gene family in metazoans.

    Jean Nicolas Volff;David Zarkower;Vivian J. Bardwell;Manfred Schartl

  • Erratum: DMRT1 prevents female reprogramming in the postnatal mammalian testis (Nature (2011) 476 (101-104))

    Clinton K. Matson;Mark W. Murphy;Aaron L. Sarver;Michael D. Griswold

Frequent Co-Authors

David Zarkower
David Zarkower University of Minnesota
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Ari Melnick
Ari Melnick Cornell University
Michael D. Griswold
Michael D. Griswold Washington State University
Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre
Paul A. Northcott
Paul A. Northcott St. Jude Children's Research Hospital
P. John Hart
P. John Hart The University of Texas Health Science Center at San Antonio
Marvin Wickens
Marvin Wickens University of Wisconsin–Madison
Olivier Elemento
Olivier Elemento Cornell University
Gilbert G. Privé
Gilbert G. Privé University of Toronto

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