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Biology and Biochemistry

D-Index
53
Citations
11906
World Ranking
16045
National Ranking
6656

Overview

David Zarkower is affiliated with the University of Minnesota in the United States. Their research spans significant areas within biochemistry, genetics, and molecular biology, with a particular focus on genetics and reproductive medicine. Their work addresses key aspects of sex determination, sexual differentiation, and disorders related to these biological processes.

Zarkower's recent publications include:

  • DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis, 2021, Sexual Development
  • The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming, 2021, Nucleic Acids Research
  • Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis, 2022, PLoS Genetics
  • Genomics of sexual cell fate transdifferentiation in the mouse gonad, 2022, G3 Genes Genomes Genetics

The publication venues where Zarkower has contributed include:

  • Sexual Development
  • Nucleic Acids Research
  • PLoS Genetics
  • G3 Genes Genomes Genetics

The focus of Zarkower's research is centered around topics such as:

  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Sperm and Testicular Function
  • Sexual Differentiation and Disorders

They frequently collaborate with other researchers, including:

  • Mark W. Murphy
  • Vivian J. Bardwell
  • Micah D. Gearhart
  • Kellie S. Agrimson
  • Andrew L Wheeler

Zarkower's work integrates molecular biology techniques and genetic analysis to explore sexual development and cell fate decisions in both human and mouse models. This is reflected across their subfields of study, comprising:

  • Genetics
  • Reproductive Medicine
  • Molecular Biology

Best Publications

  • Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation

    Christopher S. Raymond;Mark W. Murphy;M. Gerard O'Sullivan;Vivian J. Bardwell

  • Evidence for evolutionary conservation of sex-determining genes

    Christopher S. Raymond;Caroline E. Shamu;Caroline E. Shamu;Michael M. Shen;Michael M. Shen;Kelly J. Seifert

  • DMRT1 prevents female reprogramming in the postnatal mammalian testis

    Clinton K. Matson;Mark W. Murphy;Aaron L. Sarver;Michael D. Griswold

  • Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.

    Christopher S. Raymond;Jae R. Kettlewell;Betsy Hirsch;Vivian J. Bardwell

  • Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity.

    Clinton K. Matson;David Zarkower

  • A Region of Human Chromosome 9p Required for Testis Development Contains Two Genes Related to Known Sexual Regulators

    Christopher S. Raymond;Emily D. Parker;Jae R. Kettlewell;Laura G. Brown

  • The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells

    Clinton K. Matson;Clinton K. Matson;Mark W. Murphy;Michael D. Griswold;Shosei Yoshida

  • Establishing sexual dimorphism: conservation amidst diversity?

    David Zarkower

  • Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins

    David Zarkower;Jonathan Hodgkin

  • Temperature-Dependent Expression of Turtle Dmrt1 Prior to Sexual Differentiation

    Jae R. Kettlewell;Christopher S. Raymond;David Zarkower

  • Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.

    Kelly A. Loffler;David Zarkower;Peter Koopman

  • Restriction Site-Associated DNA Sequencing (RAD-seq) Reveals an Extraordinary Number of Transitions among Gecko Sex-Determining Systems

    Tony Gamble;Tony Gamble;Jessi Coryell;Tariq Ezaz;Joshua Lynch

  • Somatic sex determination.

    David Zarkower

  • Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior.

    Woelsung Yi;Jennifer M. Ross;David Zarkower

  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

    Anthony D. Krentz;Mark W. Murphy;Shinseog Kim;Shinseog Kim;Matthew S. Cook

  • Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms

    Woelsung Yi;David Zarkower

  • Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation.

    Shinseog Kim;Vivian J Bardwell;David A Zarkower

  • Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.

    Shinseog Kim;Jae R Kettlewell;Robert C Anderson;Vivian J Bardwell

  • Evolutionary dynamics of the DM domain gene family in metazoans.

    Jean Nicolas Volff;David Zarkower;Vivian J. Bardwell;Manfred Schartl

  • Erratum: DMRT1 prevents female reprogramming in the postnatal mammalian testis (Nature (2011) 476 (101-104))

    Clinton K. Matson;Mark W. Murphy;Aaron L. Sarver;Michael D. Griswold

Frequent Co-Authors

Vivian J. Bardwell
Vivian J. Bardwell University of Minnesota
Michael D. Griswold
Michael D. Griswold Washington State University
Jennifer A. Marshall Graves
Jennifer A. Marshall Graves La Trobe University
Betsy A. Hirsch
Betsy A. Hirsch University of Minnesota
Elizabeth A. Grove
Elizabeth A. Grove University of Chicago
Yoichi Matsuda
Yoichi Matsuda Nagoya University
Jeannie T. Lee
Jeannie T. Lee Harvard University
Jason D. Lieb
Jason D. Lieb University of Chicago
Randy L. Johnson
Randy L. Johnson The University of Texas MD Anderson Cancer Center
Judith Kimble
Judith Kimble University of Wisconsin–Madison

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