Jan A. Gorter mainly focuses on Epilepsy, Status epilepticus, Pathology, Neuroscience and Epileptogenesis. The various areas that he examines in his Epilepsy study include Tailored treatment, Anesthesia, Blood–brain barrier, MEDLINE and Pharmacology. His study in Status epilepticus is interdisciplinary in nature, drawing from both Entorhinal cortex and Temporal lobe.
His research in Pathology intersects with topics in Cortical dysplasia and Cortex. Jan A. Gorter is interested in Hippocampus, which is a branch of Neuroscience. His Epileptogenesis research includes themes of Gliosis and PI3K/AKT/mTOR pathway.
Jan A. Gorter spends much of his time researching Neuroscience, Epilepsy, Epileptogenesis, Status epilepticus and Hippocampus. His work deals with themes such as Glutamate receptor, Kainic acid and microRNA, which intersect with Neuroscience. His Epilepsy study integrates concerns from other disciplines, such as Pathology, Pharmacology and Blood–brain barrier.
His Epileptogenesis study incorporates themes from Inflammation, Microglia, Gliosis, Entorhinal cortex and PI3K/AKT/mTOR pathway. His Status epilepticus research includes elements of Anesthesia, Endocrinology, Stimulation, Internal medicine and Gene expression. His work carried out in the field of Hippocampus brings together such families of science as Hippocampal sclerosis and Serial analysis of gene expression.
His main research concerns Epilepsy, Epileptogenesis, Neuroscience, Status epilepticus and Pharmacology. His Epilepsy research is multidisciplinary, incorporating elements of Blood–brain barrier and Pathology. His Epileptogenesis study introduces a deeper knowledge of Hippocampus.
His Neuroscience research incorporates elements of microRNA and Rat model. The various areas that he examines in his Status epilepticus study include Pilocarpine, Anesthesia, Stimulation and Gene expression. His research investigates the link between Pharmacology and topics such as NMDA receptor that cross with problems in Glycine Plasma Membrane Transport Proteins, Glycine receptor, Anticonvulsant and Antagonist.
His primary scientific interests are in Epilepsy, Epileptogenesis, Neuroscience, Blood–brain barrier and Status epilepticus. His studies deal with areas such as Tailored treatment, Clinical trial, Drug development, Inflammatory pathways and Inflammatory molecules as well as Epilepsy. The Epileptogenesis study which covers PI3K/AKT/mTOR pathway that intersects with Pharmacology, Neuronal firing, Homeostasis, Traumatic brain injury and Stimulation.
His Brain tissue research extends to the thematically linked field of Neuroscience. His biological study spans a wide range of topics, including Gadobutrol and Pathology. His Status epilepticus research is multidisciplinary, incorporating perspectives in Brain damage and Kindling.
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Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy
E. A. van Vliet;S. da Costa Araújo;S. Redeker;R. van Schaik.
The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders
D.E. Pellegrini-Giampietro;J.A. Gorter;M.V.L. Bennett;R.S. Zukin.
Trends in Neurosciences (1997)
Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons.
J. A. Gorter;E. A. Van Vliet;E. Aronica;F. H. Lopes Da Silva.
European Journal of Neuroscience (2001)
Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca2+ Influx in Hippocampal CA1 Neurons of Gerbil
J.A. Gorter;J.J. Petrozzino;E.M.A. Aronica;D.M. Rosenbaum.
The Journal of Neuroscience (1997)
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
Anand Iyer;Emanuele Zurolo;Avanita Prabowo;Kees Fluiter.
PLOS ONE (2012)
Potential New Antiepileptogenic Targets Indicated by Microarray Analysis in a Rat Model for Temporal Lobe Epilepsy
Jan A Gorter;Erwin A van Vliet;Eleonora Aronica;Timo Breit.
The Journal of Neuroscience (2006)
Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance
Massimo Rizzi;Silvio Caccia;Giovanna Guiso;Cristina Richichi.
The Journal of Neuroscience (2002)
Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy.
Eleonora Aronica;Erwin A. Van Vliet;Oleg A. Mayboroda;Dirk Troost.
European Journal of Neuroscience (2000)
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.
Eleonora Aronica;Jan A. Gorter;Helen Ijlst-Keizers;Annemieke J. Rozemuller.
European Journal of Neuroscience (2003)
Expression pattern of miR‐146a, an inflammation‐associated microRNA, in experimental and human temporal lobe epilepsy
E. Aronica;K. Fluiter;A. Iyer;E. Zurolo.
European Journal of Neuroscience (2010)
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