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Neuroscience

D-Index
72
Citations
15745
World Ranking
2339
National Ranking
77

Overview

Jan A. Gorter is a researcher affiliated with the University of Amsterdam in the Netherlands. Their work spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with particular focus on physiology, nutrition and dietetics, pediatrics, perinatology and child health, molecular biology, and psychiatry and mental health.

The primary research topics addressed by Jan A. Gorter's publications include epilepsy research and treatment, trace elements in health, diet and metabolism studies, pharmacological effects and toxicity studies, metabolism and genetic disorders, S100 proteins and annexins, and neuroscience and neuropharmacology research.

Jan A. Gorter's recent papers demonstrate a focus on neurological conditions, neuroinflammation, and epilepsy. Key publications include:

  • Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury (2020) in Neurobiology of Disease
  • mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment (2024) in Nature Reviews Neuroscience
  • Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy (2021) in Acta Neuropathologica
  • The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects (2020) in Journal of Clinical Investigation
  • Role of blood-brain barrier dysfunction in the development of poststroke epilepsy (2024) in Epilepsia

The frequent coauthors collaborating with Jan A. Gorter include Erwin A. van Vliet, Eleonora Aronica, Diede W. M. Broekaart, James D. Mills, and Jasper J. Anink. These coauthors appear regularly in Gorter's research publications, indicating ongoing scientific partnerships.

Jan A. Gorter's work has appeared in several publication venues, with multiple contributions to:

  • Epilepsia
  • Scientific Reports
  • Experimental Neurology
  • Epilepsie periodiek voor professionals
  • Neurobiology of Disease

The bulk of Jan A. Gorter's research outputs lie in medicine-related disciplines with a significant overlap into biochemistry and molecular biology, reflecting a multidisciplinary approach to studying neurological diseases and metabolic disorders. Their studies cover physiological processes, nutritional aspects, child health, molecular mechanisms, and psychiatric conditions.

Best Publications

  • Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy

    E. A. van Vliet;S. da Costa Araújo;S. Redeker;R. van Schaik

  • The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

    D.E. Pellegrini-Giampietro;J.A. Gorter;M.V.L. Bennett;R.S. Zukin

  • Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons.

    J. A. Gorter;E. A. Van Vliet;E. Aronica;F. H. Lopes Da Silva

  • MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.

    Anand Iyer;Emanuele Zurolo;Avanita Prabowo;Kees Fluiter

  • Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy.

    Eleonora Aronica;Erwin A. Van Vliet;Oleg A. Mayboroda;Dirk Troost

  • Potential New Antiepileptogenic Targets Indicated by Microarray Analysis in a Rat Model for Temporal Lobe Epilepsy

    Jan A Gorter;Erwin A van Vliet;Eleonora Aronica;Timo Breit

  • Advances in the development of biomarkers for epilepsy

    Asla Pitkänen;Wolfgang Löscher;Annamaria Vezzani;Albert J Becker

  • Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.

    Eleonora Aronica;Jan A. Gorter;Helen Ijlst-Keizers;Annemieke J. Rozemuller

  • Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca2+ Influx in Hippocampal CA1 Neurons of Gerbil

    J.A. Gorter;J.J. Petrozzino;E.M.A. Aronica;D.M. Rosenbaum

  • Expression pattern of miR‐146a, an inflammation‐associated microRNA, in experimental and human temporal lobe epilepsy

    E. Aronica;K. Fluiter;A. Iyer;E. Zurolo

  • Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance

    Massimo Rizzi;Silvio Caccia;Giovanna Guiso;Cristina Richichi

  • Expression and Cellular Distribution of Multidrug Resistance–related Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy

    Eleonora Aronica;Jan A. Gorter;Marja Ramkema;Sandra Redeker

  • Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

    E.M.A. Aronica;J.A. Gorter;G.H. Jansen;C.W.M. van Veelen

  • Blood–brain barrier dysfunction, seizures and epilepsy

    E.A. van Vliet;E. Aronica;J.A. Gorter

  • Complement activation in experimental and human temporal lobe epilepsy.

    E. Aronica;K. Boer;E.A. van Vliet;S. Redeker

  • Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

    Erwin A. van Vliet;Grazia Forte;Linda Holtman;Jeroen C. G. den Burger

  • Inhibition of the Multidrug Transporter P-Glycoprotein Improves Seizure Control in Phenytoin-treated Chronic Epileptic Rats

    Erwin A. Van Vliet;Rosalinde Van Schaik;Peter M. Edelbroek;Sandra Redeker

  • Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

    Jan A. Gorter;Erwin A. van Vliet;Eleonora Aronica

  • Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development

    E. Aronica;K. Boer;S. Redeker;W.G.M. Spliet

  • Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias.

    Anand Iyer;Emanuele Zurolo;Wim G.M. Spliet;Peter C. Van Rijen

  • Global ischemia induces downregulation of GluR2 mRNA and increases AMPA receptor mediated Ca2+ influx in hippocampal CA1 neurons

    J.A. Gorter;E. Aronica;T. Opitz;M.V.L. Bennett

Frequent Co-Authors

Eleonora Aronica
Eleonora Aronica University of Amsterdam
Erwin A. van Vliet
Erwin A. van Vliet University of Amsterdam
Wytse J. Wadman
Wytse J. Wadman University of Amsterdam
F.H. Lopes da Silva
F.H. Lopes da Silva University of Amsterdam
Peter C. van Rijen
Peter C. van Rijen Utrecht University
Heidrun Potschka
Heidrun Potschka Ludwig-Maximilians-Universität München
Annamaria Vezzani
Annamaria Vezzani Mario Negri Institute for Pharmacological Research
Sanjay M. Sisodiya
Sanjay M. Sisodiya University College London
Asla Pitkänen
Asla Pitkänen University of Eastern Finland
Michele Simonato
Michele Simonato University of Ferrara

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