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Yoshitaka Nagahama

Yoshitaka Nagahama

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
41354
World Ranking
1106
National Ranking
62

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Yoshitaka Nagahama is affiliated with Ehime University in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on genetic and clinical aspects of sex determination and chromosomal abnormalities, reproductive biology with an emphasis on aquatic species, animal behavior and reproduction, sexual differentiation and disorders, sperm and testicular function, neuroendocrine regulation and behavior, and hypothalamic control of reproductive hormones.

The scientist's body of work includes publications in notable venues such as Physiological Reviews, Current Biology, eLife, Cell Death and Differentiation, and Scientific Reports. Some of their recent papers include:

  • "Sex determination, gonadal sex differentiation, and plasticity in vertebrate species" (2020, Physiological Reviews)
  • "Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka" (2021, Current Biology)
  • "Male-predominant galanin mediates androgen-dependent aggressive chases in medaka" (2020, eLife)
  • "Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver" (2020, Cell Death and Differentiation)
  • "Testicular inducing steroidogenic cells trigger sex change in groupers" (2021, Scientific Reports)

Frequent coauthors collaborating with Nagahama include Kohei Ohta, Masaru Nakamura, Tapas Chakraborty, Bindhu Paul-Prasanth, and Kataaki Okubo.

Their research spans several subfields, including genetics, physiology, reproductive medicine, ecology, evolution, behavior and systematics, and molecular biology.

Best Publications

  • Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences

    Robert H. Devlin;Yoshitaka Nagahama

  • DMY is a Y-specific DM-domain gene required for male development in the medaka fish

    Masaru Matsuda;Yoshitaka Nagahama;Ai Shinomiya;Tadashi Sato

  • Gonadal sex differentiation in teleost fish

    Masaru Nakamura;Tohru Kobayashi;Xiao-Tian Chang;Yoshitaka Nagahama

  • Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus

    Shigeho Ijiri;Hiroyo Kaneko;Tohru Kobayashi;De-Shou Wang;De-Shou Wang

  • Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes

    Tohru Kobayashi;Masaru Matsuda;Masaru Matsuda;Hiroko Kajiura-Kobayashi;Aya Suzuki

  • Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus)

    T Kitano;K Takamune;T Kobayashi;Y Nagahama

  • A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus.

    Minghui Li;Yunlv Sun;Jiue Zhao;Hongjuan Shi

  • The vasa-like gene, olvas, identifies the migration path of primordial germ cells during embryonic body formation stage in the medaka, Oryzias latipes.

    Ai Shinomiya;Minoru Tanaka;Tohru Kobayashi;Yoshitaka Nagahama

  • The role of hormones in the acquisition of sperm motility in salmonid fish.

    Takeshi Miura;Takeshi Miura;Kohei Yamauchi;Hiroya Takahashi;Yoshitaka Nagahama

  • Diversity and plasticity of sex determination and differentiation in fishes.

    Y. Kobayashi;Y. Nagahama;M. Nakamura

  • The duality of teleost gonadotropins.

    Hiroshi Kawauchi;Kunimasa Suzuki;Hiromichi Itoh;Penny Swanson

  • Differential expression of vasa homologue gene in the germ cells during oogenesis and spermatogenesis in a teleost fish, tilapia, Oreochromis niloticus.

    Tohru Kobayashi;Hiroko Kajiura-Kobayashi;Yoshitaka Nagahama

  • Establishment of medaka (Oryzias latipes) transgenic lines with the expression of green fluorescent protein fluorescence exclusively in germ cells: A useful model to monitor germ cells in a live vertebrate

    Minoru Tanaka;Masato Kinoshita;Daisuke Kobayashi;Yoshitaka Nagahama

  • Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17β in the ovary

    M. Tanaka;T. M. Telecky;S. Fukada;S. Adachi

  • Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes

    Masatoshi Nakamoto;Masaru Matsuda;Masaru Matsuda;De-Shou Wang;De-Shou Wang;Yoshitaka Nagahama

  • Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus).

    Xiaotian Chang;Thoru Kobayashi;Balasubramanian Senthilkumaran;Hiroko Kobayashi-Kajura

  • Changes in serum concentrations of steroid hormones, thyroxine, and vitellogenin during spawning migration of the chum slamon, Oncorhynchus keta

    Hiroshi Ueda;Osamu Hiroi;Akihiko Hara;Kohei Yamauchi

  • Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey

    Masaru Nakamura;Thomas F. Hourigan;Kohei Yamauchi;Yoshitaka Nagahama

  • DMY gene induces male development in genetically female (XX) medaka fish

    Masaru Matsuda;Ai Shinomiya;Masato Kinoshita;Aya Suzuki

  • Induction of XY sex reversal by estrogen involves altered gene expression in a teleost, tilapia.

    T. Kobayashi;H. Kajiura-Kobayashi;Y. Nagahama

Frequent Co-Authors

Balasubramanian Senthilkumaran
Balasubramanian Senthilkumaran University of Hyderabad
Minoru Tanaka
Minoru Tanaka Nagoya University
Taisen Iguchi
Taisen Iguchi National Institute for Basic Biology
Kiyoshi Naruse
Kiyoshi Naruse National Institute for Basic Biology
Takeshi Todo
Takeshi Todo Osaka University
Robert H. Devlin
Robert H. Devlin Fisheries and Oceans Canada
Ken-ichirou Morohashi
Ken-ichirou Morohashi Kyushu University
Yoichi Matsuda
Yoichi Matsuda Nagoya University
Ishwar S. Parhar
Ishwar S. Parhar University of Toyama
Yoshitaka Oka
Yoshitaka Oka University of Tokyo

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