World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
15012
World Ranking
18555
National Ranking
7580

Overview

Natasha J. Caplen is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a significant number of publications in Molecular Biology and Genetics. Caplen's work also spans areas of Pulmonary and Respiratory Medicine, Oncology, and Immunology.

The scientist has contributed extensively to topics such as RNA modifications and cancer, RNA research and splicing, sarcoma diagnosis and treatment, virus-based gene therapy research, RNA and protein synthesis mechanisms, DNA repair mechanisms, and genomics and chromatin dynamics.

Among Caplen's recent papers are:

  • HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript (2022, Nucleic Acids Research)
  • CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma (2020, Molecular Cancer Therapeutics)
  • The HNRNPF/H RNA binding proteins and disease (2023, Wiley Interdisciplinary Reviews - RNA)
  • DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains (2024, The EMBO Journal)
  • The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability (2023, Journal of Cell Science)

Caplen's frequent coauthors include Soumya Sundara Rajan, Tamara L. Jones, Tayvia Brownmiller, Katelyn R. Ludwig, and Raj Chari. This collaboration network highlights interdisciplinary connections within their research projects.

The scientist has published regularly in several scientific venues, with notable frequency in Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Molecular Cancer Therapeutics, Molecular and Cellular Biology, and Nucleic Acids Research.

Best Publications

  • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

    Nozomu Yanaihara;Natasha Caplen;Elise Bowman;Masahiro Seike

  • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.

    Natasha J. Caplen;Susan Parrish;Farhad Imani;Andrew Fire

  • Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.

    Natasha J. Caplen;Eric W.F.W. Alton;Peter G. Mddleton;Julia R. Dorin

  • Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

    Peter C. Scacheri;Orit Rozenblatt-Rosen;Natasha J. Caplen;Tyra G. Wolfsberg

  • Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

    E W Alton;P G Middleton;N J Caplen;S N Smith

  • dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

    Natasha J. Caplen;Jamie Fleenor;Andrew Fire;Richard A. Morgan

  • Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

    Joseph A. Ludwig;Gergely Szakács;Scott E. Martin;Benjamin F. Chu

  • RNAi microarray analysis in cultured mammalian cells.

    Spyro Mousses;Natasha J. Caplen;Robert Cornelison;Don Weaver

  • Defining and assaying RNAi in mammalian cells.

    Konrad Huppi;Scott E. Martin;Natasha J. Caplen

  • p53-Dependent induction of PVT1 and miR-1204.

    Anthony M. Barsotti;Rachel Beckerman;Oleg Laptenko;Konrad Huppi

  • The identification of microRNAs in a genomically unstable region of human chromosome 8q24.

    Konrad Huppi;Natalia Volfovsky;Timothy Runfola;Tamara L. Jones

  • RNAi as a gene therapy approach

    Natasha J Caplen

  • Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

    Natasha J. Caplen;J. Paul Taylor;Victoria S. Statham;Fumiaki Tanaka

  • In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE

    N. J. Caplen;E. Kinrade;F. Sorgi;X. Gao

  • Applications of RNA interference in mammalian systems.

    Scott E. Martin;Natasha J. Caplen

  • Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.

    Yong-Wei Zhang;Tamara L. Jones;Scott E. Martin;Natasha J. Caplen

  • The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro

    M Stern;NJ Caplen;JE Browning;U Griesenbach

  • Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton

    Derek Dombroski;Richard A. Houghtling;Christine M. Labno;Patricia Precht

  • The 8q24 Gene Desert: An Oasis of Non-Coding Transcriptional Activity

    Konrad Huppi;Jason J. Pitt;Brady M. Wahlberg;Natasha J. Caplen

  • Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth

    P. G. Middleton;N. J. Caplen;X. Gao;Leaf Huang

Frequent Co-Authors

Duncan M. Geddes
Duncan M. Geddes Imperial College London
Eric W.F.W. Alton
Eric W.F.W. Alton National Institutes of Health
Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles
John N. Weinstein
John N. Weinstein The University of Texas MD Anderson Cancer Center
Leaf Huang
Leaf Huang University of North Carolina at Chapel Hill
Thomas Ried
Thomas Ried National Institutes of Health
Yves Pommier
Yves Pommier National Institutes of Health
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute
Robert Williamson
Robert Williamson University of Melbourne
David J. Porteous
David J. Porteous University of Edinburgh

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Biology or Biochemistry opens doors to many dynamic careers in healthcare, research, and nutrition. Today, online programs make it easier than ever to start or advance in these fields, whether you’re aiming for clinical practice, laboratory roles, or patient care.

For those interested in food science and health, consider pursuing one of the online nutrition masters programs. These degrees can lead to roles in research, education, and wellness coaching. Alternatively, the best dietetics masters programs provide the rigorous training needed to become a registered dietitian.

Those drawn to medical imaging can explore ultrasound tech programs online, which train professionals for in-demand healthcare jobs with flexible study options. Additionally, 1 year radiology tech programs online offer accelerated pathways to entry-level roles in diagnostic imaging.

These online degrees provide flexible, accessible options to build specialized skills, making them ideal for busy students and working professionals alike.

Best Scientists Citing Natasha J. Caplen

Trending Scientists