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Molecular Biology

D-Index
80
Citations
25202
World Ranking
994
National Ranking
526

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jack D. Keene is affiliated with Duke University in the United States. Their research spans fields including Biochemistry, Genetics and Molecular Biology, with a total of nine publications, and Immunology and Microbiology, comprising three publications.

Within these disciplines, Keene's work focuses on several subfields:

  • Molecular Biology
  • Immunology
  • Cancer Research

The main research topics addressed in their publications include:

  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms

Keene has frequently published in venues such as UNC Libraries, Biology of Reproduction, and PLoS Genetics.

Recent scientific papers authored or co-authored by Keene include:

  • A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells, 2021, Biology of Reproduction
  • SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells, 2020, UNC Libraries
  • The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation, 2023, PLoS Genetics
  • A Two-Phase Innate Host Response to Alphavirus Infection Identified by mRNP-Tagging In Vivo, 2020, UNC Libraries

Frequent co-authors collaborating with Keene include:

  • Matthew Friedersdorf
  • Victor A. Ruthig
  • Josiah Hardy
  • Blanche Capel
  • Tetsuhiro Yokonishi

In 2010, Keene was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • RNA regulons: coordination of post-transcriptional events

    Jack D. Keene

  • Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

    Victoria Brown;Victoria Brown;Peng Jin;Peng Jin;Stephanie Ceman;Stephanie Ceman;Jennifer C. Darnell

  • RNA recognition: towards identifying determinants of specificity.

    Daniel J. Kenan;Charles C. Query;Jack D. Keene

  • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

    Charles C. Query;Rex C. Bentley;Jack D. Keene

  • Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

    Neelanjan Mukherjee;David L. Corcoran;Jeffrey D. Nusbaum;Jeffrey D. Nusbaum;David W. Reid

  • RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts

    Jack D Keene;Jordan M Komisarow;Matthew B Friedersdorf

  • La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.

    K. Meerovitch;Y. V. Svitkin;H. S. Lee;F. Lejbkowicz

  • Eukaryotic mRNPs may represent posttranscriptional operons.

    Jack D Keene;Scott A Tenenbaum

  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

    Krystyna Mazan-Mamczarz;Stefanie Galbán;Isabel López de Silanes;Jennifer L. Martindale

  • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays

    Scott A. Tenenbaum;Craig C. Carson;Patrick J. Lager;Jack D. Keene

  • Proteomic and immunologic analyses of brain tumor exosomes

    Michael W. Graner;Oscar Alzate;Angelika M. Dechkovskaia;Jack D. Keene

  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

    Theophany Eystathioy;Edward K. L. Chan;Scott A. Tenenbaum;Jack D. Keene

  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.

    T. D. Levine;Fenbia Gao;P. H. King;L. G. Andrews

  • The origins of defective interfering particles of the negative-strand RNA viruses

    Robert A. Lazzarini;Jack D. Keene;Manfred Schubert

  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets

    Jack D. Keene

  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen

    Charles C. Query;Jack D. Keene

  • PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data

    David L Corcoran;Stoyan Georgiev;Neelanjan Mukherjee;Eva Gottwein

  • Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays.

    Scott A Tenenbaum;Patrick J Lager;Craig C Carson;Jack D Keene

  • Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.

    Jack D. Keene

  • Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.

    Carol Lutz-Freyermuth;Charles C. Query;Jack D. Keene

Frequent Co-Authors

David S. Pisetsky
David S. Pisetsky Duke University
Robert A. Lazzarini
Robert A. Lazzarini Icahn School of Medicine at Mount Sinai
Jeffrey Wilusz
Jeffrey Wilusz Colorado State University
Wolfgang K. Joklik
Wolfgang K. Joklik Duke University
Blanche Capel
Blanche Capel Duke University
Helen Piwnica-Worms
Helen Piwnica-Worms The University of Texas MD Anderson Cancer Center
Luiz O. F. Penalva
Luiz O. F. Penalva The University of Texas Health Science Center at San Antonio
John B. Harley
John B. Harley United States Department of Veterans Affairs
E. William St. Clair
E. William St. Clair Duke University

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