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Christopher V. Nicchitta

Christopher V. Nicchitta

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
11521
World Ranking
8890
National Ranking
3950

Overview

Christopher V. Nicchitta is affiliated with Duke University in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research primarily spans molecular biology, cell biology, oncology, genetics, and cancer research with particular focus on the mechanisms underlying RNA and protein synthesis and their regulation in disease contexts.

Their work addresses key topics including:

  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • RNA modifications and cancer
  • Endoplasmic reticulum stress and disease
  • RNA regulation and disease
  • Cancer-related molecular pathways
  • Chronic lymphocytic leukemia research

Christopher V. Nicchitta has published in a range of scientific journals, with frequent contributions appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • RNA
  • UNC Libraries
  • Seminars in Cell and Developmental Biology
  • Proceedings of the National Academy of Sciences

Selected recent publications include:

  • Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules, 2021, RNA
  • Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane, 2020, Molecular & Cellular Proteomics
  • An emerging role for the endoplasmic reticulum in stress granule biogenesis, 2022, Seminars in Cell and Developmental Biology
  • Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13, 2023, Proceedings of the National Academy of Sciences
  • Signal-noise metrics for RNA binding protein identification reveal broad spectrum protein-RNA interaction frequencies and dynamics, 2023, Nature Communications

The scientist collaborates frequently with several peers, including:

  • Qiang Chen
  • David W. Reid
  • JohnCarlo Kristofich
  • Molly M. Hannigan
  • Jessica R. Child

Christopher V. Nicchitta's research investigates molecular mechanisms associated with RNA interactions at the endoplasmic reticulum and their implications for cellular stress responses and cancer biology. Their work on stress granule biogenesis and proteomic profiling of translation mechanisms contributes to understanding how RNA and protein synthesis is regulated under physiological and pathological conditions.

Best Publications

  • HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

    Jeffrey J. Kovacs;Patrick J.M. Murphy;Stéphanie Gaillard;Xuan Zhao

  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.

    Wanping Xu;Edward Mimnaugh;Meredith F.N. Rosser;Christopher Nicchitta

  • Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

    Gregory LaMonte;Nisha Philip;Joseph Reardon;Joshua R. Lacsina

  • Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells.

    Brent Berwin;Justin P. Hart;Stuart Rice;Cecilia Gass

  • The DRiP hypothesis decennial: support, controversy, refinement and extension.

    Jonathan W. Yewdell;Christopher V. Nicchitta

  • Diversity and selectivity in mRNA translation on the endoplasmic reticulum

    David W. Reid;Christopher V. Nicchitta

  • Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation

    Christopher V. Nicchitta;Günter Blobel

  • Spermine. A regulator of mitochondrial calcium cycling.

    C V Nicchitta;J R Williamson

  • Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling.

    David W. Reid;Christopher V. Nicchitta

  • Rare codons regulate KRas oncogenesis.

    Benjamin L. Lampson;Nicole L.K. Pershing;Joseph A. Prinz;Joshua R. Lacsina

  • Heat Shock Protein 96 Is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily via TLR2 Signaling

    Qi Quan Huang;Rudina Sobkoviak;Angela R. Jockheck-Clark;Bo Shi

  • Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes

    Rachel S. Lerner;Robert M. Seiser;Tianli Zheng;Patrick J. Lager

  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

    Karen L. Soldano;Arif Jivan;Christopher V. Nicchitta;Daniel T. Gewirth

  • Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent

    Pamela A. Wearsch;Christopher V. Nicchitta

  • Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96.

    Christopher V Nicchitta

  • Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.

    Brook Pyhtila;Tianli Zheng;Patrick J. Lager;Jack D. Keene

  • Calreticulin Displays In Vivo Peptide-Binding Activity and Can Elicit CTL Responses Against Bound Peptides

    Smita Nair;Pamela A. Wearsch;Duane A. Mitchell;James J. Wassenberg

  • Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/Cotranslocation

    Jian-Ke Tie;Christopher V. Nicchitta;Gunnar von Heijne;Darrel W. Stafford

  • Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses

    Tobias Warger;Norbert Hilf;Gerd Rechtsteiner;Philipp Haselmayer

  • Short Article HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

    Jeffrey J. Kovacs;Stéphanie Gaillard;Xuan Zhao;June-Tai Wu

Frequent Co-Authors

Günter Blobel
Günter Blobel Rockefeller University
Jonathan W. Yewdell
Jonathan W. Yewdell National Institute of Allergy and Infectious Diseases
John R. Williamson
John R. Williamson University of Pennsylvania
Jack D. Keene
Jack D. Keene Duke University
Salvatore V. Pizzo
Salvatore V. Pizzo Duke University
M. Zachary Rosenthal
M. Zachary Rosenthal Duke University
Shirish Shenolikar
Shirish Shenolikar Duke University
Jen-Tsan Chi
Jen-Tsan Chi Duke University
Jack R. Bennink
Jack R. Bennink National Institute of Allergy and Infectious Diseases
Subhash G. Vasudevan
Subhash G. Vasudevan Australian National University

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