Sara C. Kozma

Overview

Best Publications

• Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

  Sung Hee Um;Francesca Frigerio;Mitsuhiro Watanabe;Frédéric Picard

  1976
  Citations

• Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

  Arkaitz Carracedo;Li Ma;Li Ma;Li Ma;Julie Teruya-Feldstein;Federico Rojo

  1653
  Citations

• Hypothalamic mTOR Signaling Regulates Food Intake

  Daniela Cota;Karine Proulx;Kathi A. Blake Smith;Sara C. Kozma

  1522
  Citations

• The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

  Greg M. Delgoffe;Thomas P. Kole;Yan Zheng;Paul E. Zarek

  1455
  Citations

• Mammalian TOR: A Homeostatic ATP Sensor

  Patrick B. Dennis;Anja Jaeschke;Masao Saitoh;Brian Fowler

  1350
  Citations

• Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

  Attila Garami;Fried J.T Zwartkruis;Takahiro Nobukuni;Manel Joaquin

  1255
  Citations

• Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

  Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine

  1250
  Citations

• S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.

  Mario Pende;Mario Pende;Sung Hee Um;Virginie Mieulet;Melanie Sticker

  1085
  Citations

• Phosphorylation and activation of p70s6k by PDK1.

  Nicholas Pullen;Patrick B. Dennis;Mirjana Andjelkovic;Almut Dufner

  1077
  Citations

• Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

  Adem Kalender;Anand Selvaraj;Anand Selvaraj;So Young Kim;So Young Kim;Pawan Gulati

  941
  Citations

• Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

  H. B. J. Jefferies;C. Reinhard;S. C. Kozma;G. Thomas

  898
  Citations

• Drosophila S6 kinase: a regulator of cell size.

  Jacques Montagne;Mary J. Stewart;Hugo Stocker;Ernst Hafen

  896
  Citations

• A guide to analysis of mouse energy metabolism

  Matthias H Tschöp;John R Speakman;John R Speakman;Jonathan R S Arch;Johan Auwerx

  867
  Citations

• mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

  Ryan J. O. Dowling;Ivan Topisirovic;Tommy Alain;Michael Bidinosti

  826
  Citations

• Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.

  Hiroshi Shima;Mario Pende;Yi Chen;Stefano Fumagalli

  799
  Citations

• Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

  Yann-Gaël Gangloff;Matthias Mueller;Stephen G. Dann;Petr Svoboda

  589
  Citations

• Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

  Mario Pende;Sara C. Kozma;Muriel Jaquet;Viola Oorschot

  558
  Citations

• The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

  R. B. Pearson;P. B. Dennis;J.-W. Han;N. A. Williamson

  553
  Citations

• Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.

  Siniša Volarević;Mary J. Stewart;Birgit Ledermann;Frederic Zilberman

  458
  Citations

• Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

  Pawan Gulati;Lawrence D. Gaspers;Stephen G. Dann;Manel Joaquin

  422
  Citations