World's Best Scientists 2026 revealed!

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Medicine

D-Index
88
Citations
62104
World Ranking
12881
National Ranking
1209

Overview

Clive Holmes is affiliated with the University of Southampton in the United Kingdom. Their research focuses primarily on Alzheimer's disease and dementia, exploring mechanisms of neurodegeneration, neuroinflammation, and potential therapeutic approaches.

The scientist's recent publications include:

  • Common variants in Alzheimer's disease and risk stratification by polygenic risk scores, 2021, Nature Communications
  • Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease, 2022, Nature Genetics
  • The Locus Coeruleus in Aging and Alzheimer's Disease: A Postmortem and Brain Imaging Review, 2021, Journal of Alzheimer s Disease
  • Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer's Disease: A Review, 2022, Frontiers in Human Neuroscience
  • Neuroinflammation in dementia with Lewy bodies: a human post-mortem study, 2020, Translational Psychiatry

Their frequent co-authors include Bernadette McGuinness, Anthony Peter Passmore, Jessica L. Teeling, Afina W. Lemstra, and Daniela Galimberti.

Holmes publishes often in venues such as Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Journal of Alzheimer s Disease, Nature Communications, and World Journal of Psychiatry.

The main fields of study covered in their work are Medicine and Neuroscience. Subfields include Physiology, Neurology, Psychiatry and Mental Health, Radiology, Nuclear Medicine and Imaging, and Molecular Biology.

The primary research topics addressed by Holmes are:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurological Disease Mechanisms and Treatments
  • Rheumatoid Arthritis Research and Therapies
  • Tryptophan and brain disorders
  • Advanced Neuroimaging Techniques and Applications

Holmes has also contributed to book publications, including a work published by Cambridge University Press titled Textbook of Immunopsychiatry in 2021.

Best Publications

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Microglia in neurodegenerative disease

    V. Hugh Perry;James A. R. Nicoll;Clive Holmes

  • Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

    Clive Holmes;Clive Holmes;Delphine Boche;David Wilkinson;David Wilkinson;Ghasem Yadegarfar;Ghasem Yadegarfar

  • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

    James A.R. Nicoll;James A.R. Nicoll;David Wilkinson;David Wilkinson;Clive Holmes;Clive Holmes;Phil Steart

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • SYSTEMIC INFLAMMATION AND DISEASE PROGRESSION IN ALZHEIMER DISEASE

    C. Holmes;C. Cunningham;E. Zotova;J. Woolford

  • Microglial priming in neurodegenerative disease.

    V. Hugh Perry;Clive Holmes

  • Systemic infections and inflammation affect chronic neurodegeneration.

    V. Hugh Perry;Colm Cunningham;Clive Holmes

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Donepezil and memantine for moderate-to-severe Alzheimer's disease.

    Robert Howard;Rupert McShane;James Lindesay;Craig Ritchie

  • The Montreal Cognitive Assessment: validity and utility in a memory clinic setting

    Tasha Smith;Nadia Gildeh;Clive Holmes

  • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Lesley Jones;Peter A. Holmans;Marian L. Hamshere;Denise Harold

  • The epidemiology of DSM-III-R bipolar I disorder in a general population survey

    Ronald C. Kessler;D. R. Rubinow;C. Holmes;J. M. Abelson

  • Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study

    Ian McKeith;John O'Brien;Zuzana Walker;Klaus Tatsch

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

James A. R. Nicoll
James A. R. Nicoll University of Southampton
Clive Ballard
Clive Ballard University of Exeter
Delphine Boche
Delphine Boche University of Southampton
Seth Love
Seth Love University of Bristol
Kevin Morgan
Kevin Morgan University of Nottingham
Simon Lovestone
Simon Lovestone University of Oxford
Alistair Burns
Alistair Burns University of Manchester
John T. O'Brien
John T. O'Brien University of Cambridge
Julie Williams
Julie Williams Cardiff University
John Hardy
John Hardy University College London

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