World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
25087
World Ranking
3867
National Ranking
1917

Research.com Recognitions

  • 2018 - Fellow of the American Academy of Arts and Sciences

Overview

Judith Frydman is affiliated with Stanford University in the United States. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Genetics, and Materials Chemistry. They have contributed extensively in topics related to heat shock proteins research, endoplasmic reticulum stress and disease, mitochondrial function and pathology, genetic neurodegenerative diseases, protein structure and dynamics, enzyme structure and function, and RNA and protein synthesis mechanisms.

Frydman has authored multiple papers in well-regarded scientific journals. Selected recent publications include:

  • Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis, 2022, Nature
  • Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network, 2020, Molecular Cell
  • Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells, 2020, Structure
  • A defective viral genome strategy elicits broad protective immunity against respiratory viruses, 2021, Cell
  • Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells, 2021, eLife

Their frequent co-authors comprise Wah Chiu, Ranen Aviner, Raul Andino, Daniel R. Gestaut, and Patrick Dolan, indicating collaborative work across a range of expertise. Frydman has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Trends in Biochemical Sciences, Nature, Biophysical Journal, and Proceedings of the National Academy of Sciences.

Over the course of their career, Frydman has produced 135 publications related to Biochemistry, Genetics and Molecular Biology and 45 in the broader domain of Medicine.

Among their recognitions, Frydman was named a Fellow of the American Academy of Arts and Sciences in 2018.

Best Publications

  • Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones

    Judith Frydman

  • Misfolded proteins partition between two distinct quality control compartments

    Daniel Kaganovich;Ron Kopito;Judith Frydman

  • Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

    J Frydman;E Nimmesgern;K Ohtsuka;F U Hartl

  • Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

    Amie J. McClellan;Yu Xia;Adam M. Deutschbauer;Ron W. Davis

  • Protein misfolding in neurodegenerative diseases: implications and strategies

    Patrick Sweeney;Patrick Sweeney;Hyunsun Park;Marc Baumann;John Dunlop

  • Cellular Strategies of Protein Quality Control

    Bryan Chen;Marco Retzlaff;Thomas Roos;Judith Frydman

  • Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding.

    Sebastian Pechmann;Judith Frydman

  • Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.

    J Frydman;E Nimmesgern;H Erdjument-Bromage;J S Wall

  • Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

    Christoph Spiess;Anne S. Meyer;Stefanie Reissmann;Judith Frydman

  • Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

    Dena S. Leeman;Katja Hebestreit;Tyson Ruetz;Ashley E. Webb

  • Systematic Functional Prioritization of Protein Posttranslational Modifications

    Pedro Beltrao;Pedro Beltrao;Véronique Albanèse;Lillian R. Kenner;Lillian R. Kenner;Danielle L. Swaney

  • Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

    Alice Y Yam;Alice Y Yam;Yu Xia;Yu Xia;Hen-Tzu Jill Lin;Alma Burlingame

  • The role of mutational robustness in RNA virus evolution.

    Adam S. Lauring;Judith Frydman;Raul Andino

  • In vivo newly translated polypeptides are sequestered in a protected folding environment

    Vanitha Thulasiraman;Chin‐Fen Yang;Judith Frydman

  • Chaperones get in touch: the Hip-Hop connection.

    Judith Frydman;Jörg Höhfeld

  • Principles of Chaperone-Assisted Protein Folding: Differences Between in Vitro and in Vivo Mechanisms

    Judith Frydman;F. Ulrich Hartl

  • The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

    Stephen Tam;Ron Geller;Christoph Spiess;Judith Frydman

  • Protein quality control: chaperones culling corrupt conformations.

    Amie J. McClellan;Stephen Tam;Daniel Kaganovich;Judith Frydman

  • Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

    Stéphanie Escusa-Toret;Willianne I. M. Vonk;Judith Frydman

  • The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

    Alexander Leitner;Lukasz A. Joachimiak;Andreas Bracher;Leonie Mönkemeyer

Frequent Co-Authors

Wah Chiu
Wah Chiu Stanford University
W. E. Moerner
W. E. Moerner Stanford University
Raul Andino
Raul Andino University of California, San Francisco
Junjie Zhang
Junjie Zhang Oak Ridge National Laboratory
Michael Levitt
Michael Levitt Stanford University
Paul D. Adams
Paul D. Adams Lawrence Berkeley National Laboratory
Vijay S. Pande
Vijay S. Pande Stanford University
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco

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