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Alexander Leitner

Alexander Leitner

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
13154
World Ranking
13715
National Ranking
247

Overview

Alexander Leitner is affiliated with ETH Zurich in Switzerland. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology as evidenced by their extensive publication record.

Their work covers several key topics in the life sciences, including:

  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • RNA modifications and cancer
  • Protein structure and dynamics
  • Heat shock proteins research
  • Enzyme structure and function
  • Advanced proteomics techniques and applications

Alexander Leitner has contributed to a number of recent scientific papers. Notable publications include:

  • Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry, 2020, Structure
  • Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT, 2022, Cell
  • Towards a structurally resolved human protein interaction network, 2023, Nature Structural & Molecular Biology
  • A precisely positioned MED12 activation helix stimulates CDK8 kinase activity, 2020, Proceedings of the National Academy of Sciences
  • INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module, 2020, Nature Communications

Their frequent coauthors reflect ongoing collaborations in related domains and include:

  • Frédéric H.-T. Allain
  • Chris P. Sarnowski
  • Ruedi Aebersold
  • Tebbe de Vries
  • Michael Götze

Alexander Leitner has published repeatedly in several prominent venues, which outline the primary dissemination outlets for their research:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Proceedings of the National Academy of Sciences
  • Science Advances

Best Publications

  • The minimum information about a proteomics experiment (MIAPE)

    Chris F. Taylor;Chris F. Taylor;Norman W. Paton;Norman W. Paton;Kathryn S. Lilley;Kathryn S. Lilley;Pierre Alain Binz;Pierre Alain Binz

  • Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

    Alexander Leitner;Thomas Walzthoeni;Thomas Walzthoeni;Abdullah Kahraman;Franz Herzog

  • Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines.

    Alexander Leitner;Marco Faini;Florian Stengel;Ruedi Aebersold;Ruedi Aebersold

  • Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

    Franz Herzog;Abdullah Kahraman;Daniel Boehringer;Raymond Mak

  • The Complete Structure of the 55S Mammalian Mitochondrial Ribosome

    Basil J. Greber;Philipp Bieri;Marc Leibundgut;Alexander Leitner

  • Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

    Alexander Leitner;Thomas Walzthoeni;Ruedi Aebersold

  • Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing.

    Ludovic C. Gillet;Alexander Leitner;Ruedi Aebersold

  • Architecture and conformational switch mechanism of the ryanodine receptor

    Rouslan G. Efremov;Alexander Leitner;Ruedi Aebersold;Stefan Raunser

  • false discovery rate estimation for cross- linked peptides identified by mass spectrometry

    Thomas Walzthoeni;Thomas Walzthoeni;Manfred Claassen;Alexander Leitner;Franz Herzog

  • The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

    Alexander Leitner;Lukasz A. Joachimiak;Andreas Bracher;Leonie Mönkemeyer

  • Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

    Alexander Leitner;Roland Reischl;Thomas Walzthoeni;Franz Herzog

  • Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography-tandem mass spectrometry.

    Alexander Leitner;Peter Zöllner;Wolfgang Lindner

  • The complete structure of the large subunit of the mammalian mitochondrial ribosome

    Basil J. Greber;Daniel Boehringer;Marc Leibundgut;Philipp Bieri

  • Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

    Alexander Leitner;Lukasz A. Joachimiak;Pia Unverdorben;Thomas Walzthoeni

  • Architecture of the large subunit of the mammalian mitochondrial ribosome

    Basil J. Greber;Daniel Boehringer;Alexander Leitner;Philipp Bieri

  • Epoxycyclopentenone-Containing Oxidized Phospholipids Restore Endothelial Barrier Function via Cdc42 and Rac

    Konstantin G. Birukov;Valery N. Bochkov;Anna A. Birukova;Kamon Kawkitinarong

  • Phosphopeptide enrichment using metal oxide affinity chromatography

    Alexander Leitner;Alexander Leitner

  • An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.

    Nadia Martinez-Martin;Jessica Marcandalli;Christine S. Huang;Christopher P. Arthur

  • Mass spectrometry supported determination of protein complex structure

    Thomas Walzthoeni;Alexander Leitner;Florian Stengel;Ruedi Aebersold;Ruedi Aebersold

  • A mass spectrometry–based hybrid method for structural modeling of protein complexes

    Anargyros Politis;Florian Stengel;Zoe Hall;Helena Hernández

Frequent Co-Authors

Wolfgang Lindner
Wolfgang Lindner University of Vienna
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Franz Herzog
Franz Herzog Ludwig-Maximilians-Universität München
Frank Sobott
Frank Sobott University of Leeds
Nenad Ban
Nenad Ban ETH Zurich
Karl Mechtler
Karl Mechtler Research Institute of Molecular Pathology
Judith Frydman
Judith Frydman Stanford University
Wah Chiu
Wah Chiu Stanford University
Andrej Sali
Andrej Sali University of California, San Francisco

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