Paul B. Sigler

Research.com Recognitions

• 1992 - Member of the National Academy of Sciences
• 1974 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Best Publications

• Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.

  B. F. Luisi;W. X. Xu;Z. Otwinowski;L. P. Freedman;L. P. Freedman

  1910
  Citations

• The crystal structure of the asymmetric GroEL–GroES–(ADP) 7 chaperonin complex

  Zhaohui Xu;Arthur L. Horwich;Paul B. Sigler

  1844
  Citations

• The crystal structure of the bacterial chaperonin GroEL at 2.8 A.

  Kerstin Braig;Zbyszek Otwinowski;Zbyszek Otwinowski;Rashmi Hegde;Rashmi Hegde;David C. Boisvert

  1674
  Citations

• Crystal structure of a yeast TBP/TATA-box complex.

  Youngchang Kim;James. H. Geiger;Steven Hahn;Paul B. Sigler

  1574
  Citations

• The 2.0 Å crystal structure of a heterotrimeric G protein

  David G. Lambright;John Sondek;Andrew Bohm;Nikolai P. Skiba

  1553
  Citations

• Scissors-grip model for DNA recognition by a family of leucine zipper proteins

  Charles R. Vinson;Paul B. Sigler;Steven L. McKnight

  1323
  Citations

• Crystal structure of trp repressor/operator complex at atomic resolution.

  Otwinowski Z;Schevitz Rw;Zhang Rg;Lawson Cl

  1170
  Citations

• The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.

  Joseph P. Noel;Heidi E. Hamm;Heidi E. Hamm;Paul B. Sigler

  1146
  Citations

• Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

  John Sondek;Andrew Bohm;David G. Lambright;David G. Lambright;Heidi E. Hamm

  1097
  Citations

• Interfacial catalysis: the mechanism of phospholipase A2

  David L. Scott;Steven P. White;Zbyszek Otwinowski;Wei Yuan

  915
  Citations

• Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.

  David S. Geller;Anita Farhi;Nikki Pinkerton;Michael Fradley

  872
  Citations

• Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.

  David G. Lambright;Joseph P. Noel;Joseph P. Noel;Heidi E. Hamm;Paul B. Sigler

  861
  Citations

• GTPase Mechanism of Gproteins From the 1.7-A Crystal Structure of Transducin alpha-GDP-AIF-4

  John Sondek;David G. Lambright;Joseph P. Noel;Heidi E. Hamm;Heidi E. Hamm

  818
  Citations

• Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

  Kathryn M. Ferguson;Mark A. Lemmon;Joseph Schlessinger;Paul B. Sigler

  784
  Citations

• Structural determinants of nuclear receptor assembly on DNA direct repeats.

  Fraydoon Rastinejad;Thomas Perlmann;Thomas Perlmann;Ronald M. Evans;Paul B. Sigler

  736
  Citations

• Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

  Mark A. Lemmon;Kathryn M. Ferguson;Ronan O'Brien;Paul B. Sigler

  733
  Citations

• STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING

  Paul B. Sigler;Zhaohui Xu;Hays S. Rye;Steven G. Burston

  704
  Citations

• The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

  Freedman Lp;Luisi Bf;Korszun Zr;Basavappa R

  694
  Citations

• A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin

  Joel A. Hirsch;Carsten Schubert;Vsevolod V. Gurevich;Paul B. Sigler;Paul B. Sigler

  604
  Citations

• Transcriptional activation. Acid blobs and negative noodles.

  Paul B. Sigler

  563
  Citations