His primary areas of study are Transcription factor, Nuclear receptor, Biochemistry, Binding site and Calcitriol receptor. While the research belongs to areas of Transcription factor, Leonard P. Freedman spends his time largely on the problem of Molecular biology, intersecting his research to questions surrounding Psychological repression, Retinoic acid, Retinoid X receptor gamma and Retinoic acid receptor beta. The Nuclear receptor study combines topics in areas such as Receptor and Cell biology.
He is studying Zinc finger, which is a component of Biochemistry. His Binding site study which covers Stereochemistry that intersects with Recombinant DNA, Protein structure, Peptide sequence, DNA and Base pair. He specializes in Calcitriol receptor, namely Vitamin D3 Receptor.
Leonard P. Freedman mainly focuses on Nuclear receptor, Cell biology, Calcitriol receptor, Receptor and Biochemistry. His work carried out in the field of Nuclear receptor brings together such families of science as Steroid hormone and Signal transduction. His Cell biology research is multidisciplinary, relying on both Coactivator, Chromatin and Transcriptional regulation.
The various areas that Leonard P. Freedman examines in his Calcitriol receptor study include VDRE, Molecular biology, U937 cell and Cellular differentiation. His Binding site research includes elements of Stereochemistry and DNA. His research in Stereochemistry tackles topics such as Peptide sequence which are related to areas like Base pair and Recombinant DNA.
Leonard P. Freedman mainly investigates Preclinical research, Reproducibility, Engineering ethics, Drug development and Science research. Among his Preclinical research studies, there is a synthesis of other scientific areas such as Research community, Translational research, Global problem, Open access publishing and Research design. Leonard P. Freedman incorporates a variety of subjects into his writings, including Reproducibility, Reference standards, Environmental economics, Research management, Lag and Environmental resource management.
His Engineering ethics research covers fields of interest such as Political science, Publication bias, Ideation, Research findings and Process. Drug development is often connected to MEDLINE in his work. Leonard P. Freedman integrates many fields, such as Knowledge production and engineering, in his works.
Preclinical research, Reproducibility, Engineering ethics, Bioinformatics and Risk analysis are his primary areas of study. His Preclinical research study overlaps with Research design, Drug development, Publication bias, Research community and Scale. His Reproducibility research overlaps with Industrial research, Knowledge production, Intensive care medicine, Biological sciences and Science research.
Engineering ethics is intertwined with Identification, Open access publishing, Research quality, Data sharing and Clinical trial in his study. In his papers, he integrates diverse fields, such as Bioinformatics and Reference standards.
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.
B. F. Luisi;W. X. Xu;Z. Otwinowski;L. P. Freedman;L. P. Freedman.
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.
Min Liu;Mong Hong Lee;Marc Cohen;Madhavi Bommakanti.
Genes & Development (1996)
The Economics of Reproducibility in Preclinical Research
Leonard P. Freedman;Iain M. Cockburn;Timothy S. Simcoe.
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.
Christophe Rachez;Bryan D. Lemon;Zalman Suldan;Virginia Bromleigh.
Solution structure of the glucocorticoid receptor DNA-binding domain
Torleif Härd;Edwin Kellenbach;Rolf Boelens;Bonnie A. Maler.
The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
Leonard P. Freedman;Ben F. Luisi;Z. Richard Korszun;Ravi Basavappa.
Increasing the Complexity of Coactivation in Nuclear Receptor Signaling
Leonard P Freedman.
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
Christophe Rachez;Zalman Suldan;Jeremy Ward;Chao-Pei Betty Chang.
Genes & Development (1998)
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
I Alroy;T L Towers;L P Freedman.
Molecular and Cellular Biology (1995)
Anatomy of the steroid receptor zinc finger region
Leonard P. Freedman.
Endocrine Reviews (1992)
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