Leonard P. Freedman

Overview

Best Publications

• Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.

  B. F. Luisi;W. X. Xu;Z. Otwinowski;L. P. Freedman;L. P. Freedman

  1910
  Citations

• The Economics of Reproducibility in Preclinical Research

  Leonard P. Freedman;Iain M. Cockburn;Timothy S. Simcoe

  1131
  Citations

• Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

  Min Liu;Mong Hong Lee;Marc Cohen;Madhavi Bommakanti

  1073
  Citations

• Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

  Christophe Rachez;Bryan D. Lemon;Zalman Suldan;Virginia Bromleigh

  873
  Citations

• Solution structure of the glucocorticoid receptor DNA-binding domain

  Torleif Härd;Edwin Kellenbach;Rolf Boelens;Bonnie A. Maler

  738
  Citations

• The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

  Freedman Lp;Luisi Bf;Korszun Zr;Basavappa R

  694
  Citations

• Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

  Leonard P Freedman

  535
  Citations

• A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

  Christophe Rachez;Zalman Suldan;Jeremy Ward;Chao-Pei Betty Chang

  503
  Citations

• Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.

  I Alroy;T L Towers;L P Freedman

  489
  Citations

• Anatomy of the steroid receptor zinc finger region

  Leonard P. Freedman

  462
  Citations

• Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.

  Susan A Krum;Gustavo A Miranda-Carboni;Peter V Hauschka;Jason S Carroll

  420
  Citations

• Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions

  Christophe Rachez;Leonard P. Freedman

  403
  Citations

• Transcriptional Activation of the Human p21WAF1/CIP1 Gene by Retinoic Acid Receptor CORRELATION WITH RETINOID INDUCTION OF U937 CELL DIFFERENTIATION

  Min Liu;Antonio Iavarone;Leonard P. Freedman

  386
  Citations

• Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

  William Yang;Jian Shen;Min Wu;Marcello Arsura

  376
  Citations

• Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.

  Adam B. Hittelman;Darya Burakov;Jorge A. Iñiguez‐Lluhí;Leonard P. Freedman

  365
  Citations

• 1,25-Dihydroxyvitamin D3 Inhibits IFN-γ and IL-4 Levels During In Vitro Polarization of Primary Murine CD4+ T Cells

  Teodora P. Staeva-Vieira;Leonard P. Freedman

  362
  Citations

• Mediator complexes and transcription

  Christophe Rachez;Leonard P Freedman

  344
  Citations

• A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

  Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  343
  Citations

• Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

  Mark Schena;Leonard P. Freedman;Keith R. Yamamoto

  309
  Citations

• Signaling by estrogens.

  Boris J. Cheskis;James G. Greger;Sunil Nagpal;Leonard P. Freedman

  288
  Citations