What is he best known for?
The fields of study he is best known for:
- Gene
- DNA
- Transcription factor
His primary areas of study are Transcription factor, Nuclear receptor, Biochemistry, Binding site and Calcitriol receptor.
While the research belongs to areas of Transcription factor, Leonard P. Freedman spends his time largely on the problem of Molecular biology, intersecting his research to questions surrounding Psychological repression, Retinoic acid, Retinoid X receptor gamma and Retinoic acid receptor beta.
The Nuclear receptor study combines topics in areas such as Receptor and Cell biology.
He is studying Zinc finger, which is a component of Biochemistry.
His Binding site study which covers Stereochemistry that intersects with Recombinant DNA, Protein structure, Peptide sequence, DNA and Base pair.
He specializes in Calcitriol receptor, namely Vitamin D3 Receptor.
His most cited work include:
- Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. (1257 citations)
- Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. (1257 citations)
- Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. (828 citations)
What are the main themes of his work throughout his whole career to date?
Leonard P. Freedman mainly focuses on Nuclear receptor, Cell biology, Calcitriol receptor, Receptor and Biochemistry.
His work carried out in the field of Nuclear receptor brings together such families of science as Steroid hormone and Signal transduction.
His Cell biology research is multidisciplinary, relying on both Coactivator, Chromatin and Transcriptional regulation.
The various areas that Leonard P. Freedman examines in his Calcitriol receptor study include VDRE, Molecular biology, U937 cell and Cellular differentiation.
His Binding site research includes elements of Stereochemistry and DNA.
His research in Stereochemistry tackles topics such as Peptide sequence which are related to areas like Base pair and Recombinant DNA.
He most often published in these fields:
- Nuclear receptor (31.30%)
- Cell biology (28.70%)
- Calcitriol receptor (27.83%)
What were the highlights of his more recent work (between 2010-2018)?
- Preclinical research (5.22%)
- Reproducibility (3.48%)
- Engineering ethics (3.48%)
In recent papers he was focusing on the following fields of study:
Leonard P. Freedman mainly investigates Preclinical research, Reproducibility, Engineering ethics, Drug development and Science research.
Among his Preclinical research studies, there is a synthesis of other scientific areas such as Research community, Translational research, Global problem, Open access publishing and Research design.
Leonard P. Freedman incorporates a variety of subjects into his writings, including Reproducibility, Reference standards, Environmental economics, Research management, Lag and Environmental resource management.
His Engineering ethics research covers fields of interest such as Political science, Publication bias, Ideation, Research findings and Process.
Drug development is often connected to MEDLINE in his work.
Leonard P. Freedman integrates many fields, such as Knowledge production and engineering, in his works.
Between 2010 and 2018, his most popular works were:
- The Economics of Reproducibility in Preclinical Research (522 citations)
- Reproducibility: changing the policies and culture of cell line authentication (76 citations)
- The Increasing Urgency for Standards in Basic Biologic Research (54 citations)
In his most recent research, the most cited papers focused on:
- Gene
- DNA
- Transcription factor
Preclinical research, Reproducibility, Engineering ethics, Bioinformatics and Risk analysis are his primary areas of study.
His Preclinical research study overlaps with Research design, Drug development, Publication bias, Research community and Scale.
His Reproducibility research overlaps with Industrial research, Knowledge production, Intensive care medicine, Biological sciences and Science research.
Engineering ethics is intertwined with Identification, Open access publishing, Research quality, Data sharing and Clinical trial in his study.
In his papers, he integrates diverse fields, such as Bioinformatics and Reference standards.
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