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Molecular Biology

D-Index
44
Citations
16370
World Ranking
2889
National Ranking
228

Overview

Matthew N.J. Seaman is affiliated with the University of Cambridge in the United Kingdom. Their research prominently focuses on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology and cell biology subfields. They have also engaged in work related to physiology and epidemiology.

Their research topics cover a range of areas including cellular transport and secretion, lipid membrane structure and behavior, retinal development and disorders, lysosomal storage disorders research, signaling pathways in disease, CRISPR and genetic engineering, and autophagy in disease and therapy.

Matthew Seaman has authored several papers with details as follows:

  • The Retromer Complex: From Genesis to Revelations, 2021, Trends in Biochemical Sciences
  • A dimmer switch for endosome-to-cell surface recycling, 2021, The Journal of Cell Biology

They have also contributed to publications with frequent co-authors including Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther Davis, and Lena Wartosch.

Publication venues where Matthew Seaman has appeared include:

  • Trends in Biochemical Sciences
  • Nature Communications
  • Frontiers in Cell and Developmental Biology
  • iScience
  • The Journal of Cell Biology

Other recent papers in the field, although authored primarily by collaborators, contextualize the research environment surrounding Matthew Seaman:

  • Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29, 2020, Nature Communications
  • Navigating the Controversies of Retromer-Mediated Endosomal Protein Sorting, 2021, Frontiers in Cell and Developmental Biology
  • An evolving understanding of sorting signals for endosomal retrieval, 2022, iScience

Best Publications

  • Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

    Alicia Meléndez;Zsolt Tallóczy;Matthew Seaman;Eeva Liisa Eskelinen

  • A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast

    Matthew N.J. Seaman;J. Michael McCaffery;Scott D. Emr

  • Clathrin-mediated endocytosis in AP-2–depleted cells

    Alison M. Motley;Nicholas A. Bright;Matthew N.J. Seaman;Margaret S. Robinson

  • Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

    Matthew N.J. Seaman

  • The retromer complex - endosomal protein recycling and beyond.

    Matthew N. J. Seaman

  • Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

    Matthew N.J. Seaman;Eric G. Marcusson;Joan Lin Cereghino;Scott D. Emr

  • Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

    Eszter Zavodszky;Matthew N J Seaman;Kevin Moreau;Maria Jimenez-Sanchez

  • A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome

    Jennifer Hirst;Winnie W.Y. Lui;Nicholas A. Bright;Nicholas Totty

  • Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

    Matthew N. J. Seaman;Michael E. Harbour;Daniel Tattersall;Eliot Read

  • Recycle your receptors with retromer

    Matthew N.J. Seaman

  • The Fifth Adaptor Protein Complex

    Jennifer Hirst;Lael D Barlow;Gabriel Casey Francisco;Daniela A Sahlender

  • Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval.

    Matthew N. J. Seaman

  • A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.

    Bruce F. Horazdovsky;Brian A. Davies;Matthew N.J. Seaman;Steven A. McLaughlin

  • The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

    Michael E. Harbour;Sophia Y. A. Breusegem;Robin Antrobus;Caroline Freeman

  • Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.

    Michael E. Harbour;Sophia Y. Breusegem;Matthew N. J. Seaman

  • Retromer-mediated endosomal protein sorting: all WASHed up!

    Matthew N.J. Seaman;Alexis Gautreau;Daniel D. Billadeau

  • EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.

    Suzanne Gokool;Daniel Tattersall;Matthew N. J. Seaman

  • Identification of Alzheimer disease-associated variants in genes that regulate retromer function.

    Badri N. Vardarajan;Sophia Y. Bruesegem;Michael E. Harbour;Peter St. George-Hyslop;Peter St. George-Hyslop

  • Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

    Brett M Collins;Claire F Skinner;Peter J Watson;Matthew N J Seaman

  • An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.

    Rachel Allison;Jennifer H. Lumb;Coralie Fassier;Coralie Fassier;Coralie Fassier;James W. Connell

Frequent Co-Authors

Margaret S. Robinson
Margaret S. Robinson University of Cambridge
Scott D. Emr
Scott D. Emr Cornell University
Brett M. Collins
Brett M. Collins University of Queensland
Nicholas A. Bright
Nicholas A. Bright University of Cambridge
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Joel B. Dacks
Joel B. Dacks University of Alberta
Anders Nykjaer
Anders Nykjaer Aarhus University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Badri N. Vardarajan
Badri N. Vardarajan Columbia University
Lindsay A. Farrer
Lindsay A. Farrer Boston University

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