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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
13424
World Ranking
17867
National Ranking
1410

Overview

Nicholas A. Bright is a researcher affiliated with the University of Cambridge in the United Kingdom. Their scientific contributions focus primarily on the fields of Biochemistry, Genetics and Molecular Biology, with substantial work in Molecular Biology and Cell Biology. Additional areas of study include Physiology, Rheumatology, and Epidemiology.

The scientist's research topics cover a broad range of cellular and molecular processes. Key topics include:

  • Cellular transport and secretion
  • Lysosomal Storage Disorders Research
  • RNA Research and Splicing
  • Nuclear Structure and Function
  • RNA regulation and disease
  • ATP Synthase and ATPases Research
  • Photosynthetic Processes and Mechanisms

Recent publications by Nicholas A. Bright highlight investigations into cellular mechanisms and protein interactions. Notable papers include:

  • "VAMP2 regulates phase separation of α-synuclein," published in 2024 in Nature Cell Biology
  • "Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29," published in 2020 in Nature Communications
  • "Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle," published in 2024 in Molecular Biology of the Cell
  • "Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway," published in 2021 in Journal of Cell Science
  • "Juvenile mucopolysaccharidosis plus disease caused by a missense mutation in VPS33A," published in 2022 in Human Mutation

The scientist's work is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature Cell Biology, Molecular Biology of the Cell, and Human Mutation.

Nicholas A. Bright has collaborated extensively with several researchers, with frequent co-authors including:

  • J. Paul Luzio
  • Luther Davis
  • Sophia Y. Breusegem
  • Jack W. Houghton
  • Raquel Romero-Bueno

Best Publications

  • Lysosomes: fusion and function

    J. Paul Luzio;Paul R. Pryor;Nicholas A. Bright

  • Clathrin-mediated endocytosis in AP-2–depleted cells

    Alison M. Motley;Nicholas A. Bright;Matthew N.J. Seaman;Margaret S. Robinson

  • Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

    Oleg O. Glebov;Nicholas A. Bright;Benjamin J. Nichols

  • Tumor necrosis factor-alpha induces apoptosis of human adipose cells.

    Johannes B Prins;Carola U Niesler;Clay M Winterford;Nicholas A Bright

  • A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome

    Jennifer Hirst;Winnie W.Y. Lui;Nicholas A. Bright;Nicholas Totty

  • The Role of Intraorganellar Ca2+In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles

    Paul R. Pryor;Barbara M. Mullock;Nicholas A. Bright;Sally R. Gray

  • Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

    Matthew N. J. Seaman;Michael E. Harbour;Daniel Tattersall;Eliot Read

  • Lysosome-endosome fusion and lysosome biogenesis.

    J.P. Luzio;B.A. Rous;N.A. Bright;P.R. Pryor

  • Characterization of a Fourth Adaptor-related Protein Complex

    Jennifer Hirst;Nicholas A. Bright;Brian Rous;Margaret S. Robinson

  • Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells

    Nicholas A. Bright;Matthew J. Gratian;J.Paul Luzio

  • Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.

    Manfred Frick;Nicholas A. Bright;Kirsi Riento;Aurélie Bray

  • A novel adaptor-related protein complex.

    F Simpson;N A Bright;M A West;L S Newman

  • Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

    Paul R Pryor;Barbara M Mullock;Nicholas A Bright;Margaret R Lindsay

  • SDPR induces membrane curvature and functions in the formation of caveolae

    Carsten G. Hansen;Nicholas A. Bright;Gillian Howard;Benjamin J. Nichols

  • Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

    Barbara M. Mullock;Nicholas A. Bright;Clare W. Fearon;Sally R. Gray

  • Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

    David A. Tumbarello;Bennett J. Waxse;Susan D. Arden;Nicholas A. Bright

  • Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity.

    Nicholas A. Bright;Luther J. Davis;J. Paul Luzio

  • Confocal immunofluorescence localization of collagen types I, III, IV, V and VI and their ultrastructural organization in term human fetal membranes

    T.M. Malak;C.D. Ockleford;S.C. Bell;R. Dalgleish

  • Clathrin is required for the function of the mitotic spindle

    Stephen J. Royle;Nicholas A. Bright;Leon Lagnado

  • Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

    N.A. Bright;B.J. Reaves;B.M. Mullock;J.P. Luzio

Frequent Co-Authors

J. Paul Luzio
J. Paul Luzio University of Cambridge
Margaret S. Robinson
Margaret S. Robinson University of Cambridge
Robert C. Piper
Robert C. Piper University of Iowa
Jordan S. Pober
Jordan S. Pober Yale University
Matthew N.J. Seaman
Matthew N.J. Seaman University of Cambridge
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge
John C. Hutton
John C. Hutton University of Colorado Denver
Guy A. Rutter
Guy A. Rutter Imperial College London
John Kendrick-Jones
John Kendrick-Jones MRC Laboratory of Molecular Biology
Peter Vandenabeele
Peter Vandenabeele Ghent University

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