World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
20548
World Ranking
5051
National Ranking
377

Overview

J. Paul Luzio is affiliated with the University of Cambridge in the United Kingdom, focusing on research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work prominently addresses topics in Cellular transport and secretion, Calcium signaling and nucleotide metabolism, and Lysosomal Storage Disorders Research.

The scientist's research spans several subfields, including Cell Biology, Molecular Biology, Physiology, Epidemiology, and Rheumatology. Their scholarly output includes a significant number of publications exploring mechanisms related to cellular and molecular processes, particularly those involving lysosomes and endocytic pathways.

Key recent publications include:

  • Current methods to analyze lysosome morphology, positioning, motility and function, 2022, Traffic
  • A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export, 2020, Nature Communications
  • Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29, 2020, Nature Communications
  • Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle, 2024, Molecular Biology of the Cell
  • Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway, 2021, Journal of Cell Science

Frequent co-authors collaborating with J. Paul Luzio include Nicholas A. Bright, Luther Davis, Lena Wartosch, Ioana Sava, and Elena Pavlova.

The scientist has published repeatedly in several notable venues, among them:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Traffic
  • Molecular Biology of the Cell
  • Human Mutation

Luzio's research agenda extensively covers cellular transport mechanisms and secretion pathways. Their work also involves studying ATP Synthase and ATPases, photosynthetic processes and mechanisms, and autophagy in disease and therapy, as well as signaling pathways relevant to various diseases.

Best Publications

  • Lysosomes: fusion and function

    J. Paul Luzio;Paul R. Pryor;Nicholas A. Bright

  • Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

    Martin Bennett;Kirsty Macdonald;Shiu Wan Chan;J. Paul Luzio

  • Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

    J P Luzio;B Brake;G Banting;K E Howell

  • Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.

    Daniela A. Sahlender;Rhys C. Roberts;Susan D. Arden;Giulietta Spudich

  • The Role of Intraorganellar Ca2+In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles

    Paul R. Pryor;Barbara M. Mullock;Nicholas A. Bright;Sally R. Gray

  • Lysosome-endosome fusion and lysosome biogenesis.

    J.P. Luzio;B.A. Rous;N.A. Bright;P.R. Pryor

  • The Biogenesis of Lysosomes and Lysosome-Related Organelles

    J. Paul Luzio;Yvonne Hackmann;Nele M.G. Dieckmann;Gillian M. Griffiths

  • Myosin VI isoform localized to clathrin‐coated vesicles with a role in clathrin‐mediated endocytosis

    Folma Buss;Susan D. Arden;Margaret Lindsay;J. Paul Luzio

  • Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.

    Lidia M Duncan;Siân Piper;Roger B Dodd;Mark K Saville

  • Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells

    Nicholas A. Bright;Matthew J. Gratian;J.Paul Luzio

  • Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

    Paul R Pryor;Barbara M Mullock;Nicholas A Bright;Margaret R Lindsay

  • Role of Adaptor Complex AP-3 in Targeting Wild- Type and Mutated CD63 to Lysosomes

    Brian A. Rous;Barbara J. Reaves;Gudrun Ihrke;John A.G. Briggs

  • Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

    Barbara M. Mullock;Nicholas A. Bright;Clare W. Fearon;Sally R. Gray

  • Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.

    James W. Connell;Catherine Lindon;J. Paul Luzio;Evan Reid

  • Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity.

    Nicholas A. Bright;Luther J. Davis;J. Paul Luzio

  • The Localization of Myosin VI at the Golgi Complex and Leading Edge of Fibroblasts and Its Phosphorylation and Recruitment into Membrane Ruffles of A431 Cells after Growth Factor Stimulation

    Folma Buss;John Kendrick-Jones;Corinne Lionne;Alex E. Knight

  • Late endosomes: sorting and partitioning in multivesicular bodies.

    Robert C. Piper;J. Paul Luzio

  • Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

    N.A. Bright;B.J. Reaves;B.M. Mullock;J.P. Luzio

  • Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.

    Shelli M. Morris;Susan D. Arden;Rhys C. Roberts;John Kendrick-Jones

  • Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

    Katherine Bowers;Jillian Lottridge;Stephen B. Helliwell;Lisa M. Goldthwaite

Frequent Co-Authors

Nicholas A. Bright
Nicholas A. Bright University of Cambridge
Robert C. Piper
Robert C. Piper University of Iowa
Anthony K. Campbell
Anthony K. Campbell Cardiff University
John Kendrick-Jones
John Kendrick-Jones MRC Laboratory of Molecular Biology
Paul J. Lehner
Paul J. Lehner University of Cambridge
Kenneth Siddle
Kenneth Siddle University of Cambridge
B. Paul Morgan
B. Paul Morgan Cardiff University
Peter Jackson
Peter Jackson University of Sheffield
David E. James
David E. James University of Sydney
Michael S. Marks
Michael S. Marks Children's Hospital of Philadelphia

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA opens the door to a variety of online degree options and specialized career pathways. Many students are now exploring flexible learning opportunities that fit their schedules and career goals.

For those interested in the pharmaceutical field, pursuing an online pharmacy school offers a pathway to advanced clinical roles. Alternatively, a science-focused profession in human movement can start with an exercise science degree online accredited or an online kinesiology bachelor's degree. These programs are ideal for aspiring physical therapists, sports scientists, or fitness professionals.

For nurses or those already in the healthcare sector, earning one of the shortest online pmhnp certificate programs can quickly advance your ability to serve in psychiatric and mental health roles. As the scientific landscape evolves, online degrees provide a flexible route for professionals to specialize or further their education in these related fields.

Best Scientists Citing J. Paul Luzio

Trending Scientists

Recently Published Articles