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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
17737
World Ranking
9047
National Ranking
159

Overview

Susanna Cotecchia is affiliated with the University of Lausanne in Switzerland, with research focused primarily in the field of Biochemistry, Genetics and Molecular Biology. Their scientific contributions are notably concentrated on Molecular Biology, encompassing related subfields such as Health, Toxicology and Mutagenesis, Pulmonary and Respiratory Medicine, Social Psychology, and Animal Science and Zoology.

The scientist's work addresses several main topics including:

  • Receptor Mechanisms and Signaling
  • Electrolyte and hormonal disorders
  • Ion Transport and Channel Regulation
  • Ion channel regulation and function
  • Neuroendocrine regulation and behavior
  • Phosphodiesterase function and regulation
  • Pharmacological Effects and Assays

Recent publications demonstrate a focus on receptor biology and signaling pathways related to vasopressin and G protein-coupled receptors. Papers include:

  • The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation (2020, Cells)
  • Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors (2020, Scientific Reports)
  • Adrenoceptors in GtoPdb v.2021.3 (2021, IUPHAR/BPS Guide to Pharmacology CITE)
  • Structural plasticity of arrestin-G protein coupled receptor complexes as a molecular determinant of signaling (2024, International Journal of Biological Macromolecules)
  • Artificial Intelligence (AI)-Based Prospective Repurposing Studies for the Identification of New Promising Vasopressin V2 Receptor Ligands (2024, Journal of the American Society of Nephrology)

Frequent coauthors who have collaborated with Cotecchia include Mariangela Centrone, Giovanna Valenti, Marianna Ranieri, Annarita Di Mise, and Vanessa Vezzi. These collaborations reflect shared interests in receptor signaling and molecular mechanisms.

Susanna Cotecchia has published in several scientific venues such as:

  • Cells
  • Scientific Reports
  • IUPHAR/BPS Guide to Pharmacology CITE
  • International Journal of Biological Macromolecules
  • Journal of the American Society of Nephrology

Best Publications

  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

    P. Samama;S. Cotecchia;T. Costa;R.J. Lefkowitz

  • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

    Robert J. Lefkowitz;Susanna Cotecchia;Philippe Samama;Tommaso Costa

  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

    M A Kjelsberg;S Cotecchia;J Ostrowski;M G Caron

  • Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

    Susanna Cotecchia;Debra A. Schwinn;Richard R. Randall;Robert J. Lefkowitz

  • Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

    Debra A. Schwinn;Jon W. Lomasney;Wulfing Lorenz;Pamela J. Szklut

  • Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

    Jon W. Lomasney;Susanna Cotecchia;Wulfing Lorenz;Wah Ying Leung

  • Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

    A. Scheer;Francesca Fanelli;T. Costa;P. G. De Benedetti

  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

    Lee F. Allen;Robert J. Lefkowitz;Marc G. Caron;Susanna Cotecchia

  • Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

    L M Leeb-Lundberg;S Cotecchia;J W Lomasney;J F DeBernardis

  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

    Susanna Cotecchia;Sabrina Exum;Marc G. Caron;Robert J. Lefkowitz

  • Effector coupling mechanisms of the cloned 5-HT1A receptor.

    Annick Fargin;John R. Raymond;John W. Regan;Susanna Cotecchia

  • Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

    S Cotecchia;B K Kobilka;K W Daniel;R D Nolan

  • Constitutively active mutants of the alpha 2-adrenergic receptor.

    Quen Ren;Hitoshi Kurose;Robert J. Lefkowitz;Susanna Cotecchia

  • Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor

    Antonella Cavalli;Anne-Laure Lattion;Edith Hummler;Monique Nenniger

  • Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

    P. Samama;Gang Pei;T. Costa;S. Cotecchia

  • Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

    L. M.F. Leeb-Lundberg;S. Cotecchia;A. DeBlasi;M. G. Caron

  • The activation process of the α1B-adrenergic receptor: Potential role of protonation and hydrophobicity of a highly conserved aspartate

    A Scheer;Francesca Fanelli;T. Costa;P. G. De Benedetti

  • The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor

    Astrid E. Alewijnse;Henk Timmerman;Edwin H. Jacobs;Martine J. Smit

  • Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.

    P. Beguin;A.T. Beggah;A.V. Chibalin;P. Burgener-Kairuz

  • Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships

    Jon W. Lomasney;Susanna Cotecchia;Robert J. Lefkowitz;Marc G. Caron

Frequent Co-Authors

Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Marc G. Caron
Marc G. Caron Duke University
Gozoh Tsujimoto
Gozoh Tsujimoto Kyoto University
John W. Regan
John W. Regan University of Arizona
Teresa L. Yang-Feng
Teresa L. Yang-Feng Yale University
Akito Tanoue
Akito Tanoue Kumamoto University
Brian K. Kobilka
Brian K. Kobilka Stanford University
Graeme Milligan
Graeme Milligan University of Glasgow
Hitoshi Kurose
Hitoshi Kurose University of Tokushima
Käthi Geering
Käthi Geering University of Lausanne

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